6,047 research outputs found
In-Medium Effects in Photo- and Neutrino-Induced Reactions on Nuclei
In this talk various aspects of in-medium behavior of hadrons are discussed
with an emphasis on observable effects. It is stressed that final state
interactions can have a major effect on observables and thus have to be
considered as part of the theory. This is demonstrated with examples from
photo-nucleus and neutrino-nucleus interactions.Comment: Invited talk, given by U. Mosel, at MESON2006, 9-th International
Workshop on Meson Production, Interaction and Decay, June 9-13, 2006, Cracow,
Polan
Unbounded Human Learning: Optimal Scheduling for Spaced Repetition
In the study of human learning, there is broad evidence that our ability to
retain information improves with repeated exposure and decays with delay since
last exposure. This plays a crucial role in the design of educational software,
leading to a trade-off between teaching new material and reviewing what has
already been taught. A common way to balance this trade-off is spaced
repetition, which uses periodic review of content to improve long-term
retention. Though spaced repetition is widely used in practice, e.g., in
electronic flashcard software, there is little formal understanding of the
design of these systems. Our paper addresses this gap in three ways. First, we
mine log data from spaced repetition software to establish the functional
dependence of retention on reinforcement and delay. Second, we use this memory
model to develop a stochastic model for spaced repetition systems. We propose a
queueing network model of the Leitner system for reviewing flashcards, along
with a heuristic approximation that admits a tractable optimization problem for
review scheduling. Finally, we empirically evaluate our queueing model through
a Mechanical Turk experiment, verifying a key qualitative prediction of our
model: the existence of a sharp phase transition in learning outcomes upon
increasing the rate of new item introductions.Comment: Accepted to the ACM SIGKDD Conference on Knowledge Discovery and Data
Mining 201
Social marketing: Immunizing against unethical practice
A simple approach for the catalytic conversion of primary alcohols into their corresponding esters and amides, with evolution of H2 gas using in situ formed ruthenium PNP- and PNN-pincer catalysts, is presented. The evaluation showed conversions for the esterification with turnover numbers as high as 4300, and 4400 for the amidation
Continuous-Flow Asymmetric Hydrogenation of the β-Keto Ester Methyl Propionylacetate in Ionic LiquidâSupercritical Carbon Dioxide Biphasic Systems
A continuous-flow process for the asymmetric hydrogenation of methyl propionylacetate as a prototypical β-keto ester in a biphasic system of ionic liquid and supercritical carbon dioxide (scCO2) is presented. An established ruthenium/2,2â˛-bis(diphenylphosphino)-1,1â˛-binaphthyl (BINAP) catalyst was immobilised in an imidazolium-based ionic liquid while scCO2 was used as mobile phase transporting reactants in and products out of the reactor. The use of acidic additives led to significantly higher reaction rates and enhanced catalyst stability albeit at slightly reduced enantioselectivity. High single pass conversions (>90%) and good enantioselectivity (80â82% ee) were achieved in the first 80â
h. The initial catalyst activity was retained to 91% after 100â
h and to 69% after 150â
h time-on-stream, whereas the enantioselectivity remained practically constant during the entire process. A total turnover number of âź21,000 and an averaged space-time yield (STYav) of 149â
gâLâ1âhâ1 were reached in a long-term experiment. No ruthenium and phosphorus contaminants could be detected via inductively coupled plasma optical emission spectrometry (ICP-OES) in the product stream and almost quantitative retention by the analysis of the stationary phase was confirmed. A comparison between batch-wise and continuous-flow operation on the basis of these data is provided
A Fully Integrated Continuous-Flow System for Asymmetric Catalysis: Enantioselective Hydrogenation with Supported Ionic Liquid Phase Catalysts Using Supercritical CO<sub>2</sub> as the Mobile Phase
A continuous-flow process based on a chiral transition-metal complex in a supported ionic liquid phase (SILP) with supercritical carbon dioxide (scCO2) as the mobile phase is presented for asymmetric catalytic transformations of low-volatility organic substrates at mild reaction temperatures. Enantioselectivity of >99â%â
ee and quantitative conversion were achieved in the hydrogenation of dimethylitaconate for up to 30â
h, reaching turnover numbers beyond 100â000 for the chiral QUINAPHOSârhodium complex. By using an automated high-pressure continuous-flow setup, the product was isolated in analytically pure form without the use of any organic co-solvent and with no detectable catalyst leaching. Phase-behaviour studies and high-pressure NMR spectroscopy assisted the localisation of optimum process parameters by quantification of substrate partitioning between the IL and scCO2. Fundamental insight into the molecular interactions of the metal complex, ionic liquid and the surface of the support in working SILP catalyst materials was gained by means of systematic variations, spectroscopic studies and labelling experiments. In concert, the obtained results provided a rationale for avoiding progressive long-term deactivation. The optimised system reached stable selectivities and productivities that correspond to 0.7â
kgâLâ1âhâ1 spaceâtime yield and at least 100â
kg product per gram of rhodium, thus making such processes attractive for larger-scale application
Charged Current Neutrino Nucleus Interactions at Intermediate Energies
We have developed a model to describe the interactions of neutrinos with
nucleons and nuclei, focusing on the region of the quasielastic and Delta(1232)
peaks. We describe neutrino nucleon collisions with a fully relativistic
formalism which incorporates state-of-the-art parametrizations of the form
factors for both the nucleon and the N-Delta transition. The model has then
been extended to finite nuclei, taking into account nuclear effects such as
Fermi motion, Pauli blocking (both within the local density approximation),
nuclear binding and final state interactions. The in-medium modification of the
Delta resonance due to Pauli blocking and collisional broadening have also been
included. Final state interactions are implemented by means of the
Boltzmann-Uehling-Uhlenbeck (BUU) coupled-channel transport model. Results for
charged current inclusive cross sections and exclusive channels as pion
production and nucleon knockout are presented and discussed.Comment: 26 pages, 24 figures; v2: 2 figures and discussion added, version
accepted for publication in Phys. Rev.
A Turbulent Origin for Flocculent Spiral Structure in Galaxies: II. Observations and Models of M33
Fourier transform power spectra of azimuthal scans of the optical structure
of M33 are evaluated for B, V, and R passbands and fit to fractal models of
continuum emission with superposed star formation. Power spectra are also
determined for Halpha. The best models have intrinsic power spectra with 1D
slopes of around -0.7pm0.7, significantly shallower than the Kolmogorov
spectrum (slope =-1.7) but steeper than pure noise (slope=0). A fit to the
power spectrum of the flocculent galaxy NGC 5055 gives a steeper slope of
around -1.5pm0.2, which could be from turbulence. Both cases model the optical
light as a superposition of continuous and point-like stellar sources that
follow an underlying fractal pattern. Foreground bright stars are clipped in
the images, but they are so prominent in M33 that even their residual affects
the power spectrum, making it shallower than what is intrinsic to the galaxy. A
model consisting of random foreground stars added to the best model of NGC 5055
fits the observed power spectrum of M33 as well as the shallower intrinsic
power spectrum that was made without foreground stars. Thus the optical
structure in M33 could result from turbulence too.Comment: accepted by ApJ, 13 pages, 10 figure
Clinical validation of an automated fluorogenic factor XIII activity assay based on isopeptidase activity
Hereditary factor XIII (FXIII) deficiency is a rare autosomal bleeding disorder which can cause life-threatening bleeding. Acquired deficiency can be immune-mediated or due to increased consumption or reduced synthesis. The most commonly used screening test is insensitive, and widely used quantitative assays have analytical limitations. The present study sought to validate Technofluor FXIII Activity, the first isopeptidase-based assay available on a routine coagulation analyser, the Ceveron s100. Linearity was evidenced throughout the measuring range, with correlation coefficients of >0.99, and coefficients of variation for repeatability and reproducibility were 5% and 10%, respectively. A normally distributed reference range of 47.0â135.5 IU/dL was derived from 154 normal donors. Clinical samples with Technofluor FXIII Activity results between 0 and 167.0 IU/dL were assayed with BerichromÂŽ FXIII Activity, a functional ammonia release assay, and the HemosIL⢠FXIII antigen assay, generating correlations of 0.950 and 0.980, respectively. Experiments with a transglutaminase inhibitor showed that Technofluor FXIII Activity can detect inhibition of enzymatic activity. No interference was exhibited by high levels of haemolysis and lipaemia, and interference by bilirubin was evident at 18 mg/dL, a level commensurate with severe liver disease. Technofluor FXIII Activity is a rapid, accurate and precise assay suitable for routine diagnostic use with fewer interferents than ammonia release FXIII activity assays
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