428 research outputs found

    Phase Filters for 3D Localization of Point Light Sources

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    The work relates to the engineering and research of phase filters for three-dimensional localization of point light emitters. These phase filters form a light field having two clearly visible maxima in their intensity distribution (i.e. two-lobe fields). By means of numerical simulation, the influence of the amplitude and phase distortions of the wave front of the illuminating beam on the two-lobe field formation has been studied in the work. Keywords: spiral light beams, amplitude distortions, phase distortions, threedimensional localization, two-lobe field

    Technological mineralogy: development of a comprehensive assessment of titanium ores (exemplified by the Pizhemskoye deposit)

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    Technological mineralogy of titanium ores is the basis for assessing their complexity. It enables, from a unified standpoint, to trace the entire course of changes in mineral matter through operating procedures, including beneficiation, processing, and obtaining target industrial products. The study targets are Pizhemskoye ilmenite-leucoxene sandstones, which are distinguished by a complex polymineral composition. Along with the main ore components, there are other metals with different speciation (isomorphic admixture, independent mineral phases). The optimal set of mineralogical analysis methods for the predictive assessment of their further use is substantiated exemplified by titanium ores of the Pizhemskoye deposit, which are complex, noted for a variable content of iron oxides and contain rare earth metals. Examinations by X-ray phase analysis and scanning electron microscopy confirm that the main titanium phases of sandstones are pseudorutile and a polymineral aggregate, β€œleucoxene”. Considering the granulometric peculiarities of the magnetic and non-magnetic fractions of the gravity concentrate, the prospects of technologies for processing titanium raw materials are discussed. Along with the problems of obtaining high-quality raw materials, the transformations of mineral phases as a result of extreme impacts and their physicochemical properties as a consequence of isomorphic substitution of a part of Ti atoms with natural modifier agents (Fe and V) in the synthesis of titanium oxide nanostructures for industrial applications are considered (photocatalytic nanoreactor)

    Method of predicting recurrence and monitor the effectiveness of treatment of vulvovaginal candidiasis

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    They were examined 60 patients of child-bearing age, of whom 20 healthy women (group I) and 40 patients with chronic recurrent vulvovagi-nal candidiasis with different frequency of recidivating: II grou p-1-2 times per year, and III the group - 3 to 5 times once a year. We investigated the intensity of lipid peroxidation and activity of antioxidant protection system. All investigated parameters in patients with recurrent vulvovaginal candidi-asis discovered the differences from the norm, the degree of which is directly proportional to the frequency of relapses of the disease.ОбслСдовано 60 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠΊ Ρ„Π΅Ρ€Ρ‚ΠΈΠ»ΡŒΠ½ΠΎΠ³ΠΎ возраста, ΠΈΠ· Π½ΠΈΡ… 20 практичСски Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… ΠΆΠ΅Π½Ρ‰ΠΈΠ½ (I Π³Ρ€ΡƒΠΏΠΏΠ°) ΠΈ 40 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…, ΡΡ‚Ρ€Π°Π΄Π°ΡŽΡ‰ΠΈΡ… Ρ€Π΅Ρ†ΠΈΠ΄ΠΈΠ²ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌ ΠΊΠ°Π½Π΄ΠΈΠ΄ΠΎΠ·Π½Ρ‹ΠΌ Π²ΡƒΠ»ΡŒΠ²ΠΎΠ²Π°Π³ΠΈΠ½ΠΈΡ‚ΠΎΠΌ с Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ частотой обострСний: II Π³Ρ€ΡƒΠΏΠΏΠ° - с обострСниями Π²ΡƒΠ»ΡŒΠ²ΠΎΠ²Π°Π³ΠΈΠ½ΠΈΡ‚Π° 1-2 Π² Π³ΠΎΠ΄ ΠΈ III Π³Ρ€ΡƒΠΏΠΏΠ° с обострСниями Π²ΡƒΠ»ΡŒΠ²ΠΎΠ²Π°Π³ΠΈΠ½ΠΈΡ‚Π° ΠΎΡ‚ 3 Π΄ΠΎ 5 Ρ€Π°Π· Π² Π³ΠΎΠ΄. ΠžΡ†Π΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΈΠ½Ρ‚Π΅Π½ΡΠΈΠ²Π½ΠΎΡΡ‚ΡŒ пСрСкисного окислСния Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΈ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ антиоксидантной систСмы Π·Π°Ρ‰ΠΈΡ‚Ρ‹. ВсС исслСдуСмыС ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с Ρ€Π΅Ρ†ΠΈΠ΄ΠΈΠ²ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌ ΠΊΠ°Π½Π΄ΠΈΠ΄ΠΎΠ·Π½Ρ‹ΠΌ Π²ΡƒΠ»ΡŒΠ²ΠΎΠ²Π°Π³ΠΈΠ½ΠΈΡ‚ΠΎΠΌ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠΈΠ»ΠΈ отличия ΠΎΡ‚ Π½ΠΎΡ€ΠΌΡ‹, ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… оказалась прямо ΠΏΡ€ΠΎΠΏΠΎΡ€Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Π° частотС Ρ€Π΅Ρ†ΠΈΠ΄ΠΈΠ²ΠΎΠ² заболСвания

    Thermochemical characteristics of the formation of aqueous solutions of imino acids

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    The calorimetry methods are an important source of thermodynamic information in the physicochemistry of solutions of biologically active substances, including amino acids. The goal of the work was to prepare a thermodynamic description of the formation of an aqueous solution of heterocyclic imino acids, proline and hydroxyproline, that have different structures and sizes of the side radical, in a wide range of concentrations, which can be used for a qualitative analysis of changes occurring in their solutions. Thermochemical measurements of the formation of an aqueous solution of imino acids in the concentration range 1.0Β·10-3 – 40.0Β·10-3 mol/kg was performed on a MID-200 differential heat-conducting microcalorimeter at 293 K. The equilibrium moment in the solution formation was determined by the output of the thermokinetic curve to the zero line. The enthalpy of the formation of an aqueous solution of imino acids was calculated by the integration of the time dependence of thermal power. It is shown that the increase in the equilibrium time, the increase in the maximum heat flow, and the decrease in the rate of change of the heat flow during the dissolution of hydroxyproline is due to the formation of intra and intermolecular bonds in the Hypro structure with the participation of the OH group. The difference in the structure of imino acids is reflected in the sign of the thermal effect and the form of the concentration dependence of the enthalpy of formation of aqueous solutions. The exoeffect of proline dissolution is due to the stabilisation of the water structure influenced by imino acid

    ВивчСння Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ Ρƒ Ρ‚Ρ€Π°Π²Ρ– ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ— ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Ρ‚ΠΎΠ½ΠΊΠΎΡˆΠ°Ρ€ΠΎΠ²ΠΎΡ— Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ–Ρ— Ρ‚Π° високоСфСктивної Ρ€Ρ–Π΄ΠΈΠ½Π½ΠΎΡ— Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ–Ρ—

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    Topicality. The search of new plant sources of biologically active substances is an actual issue for the pharmaceuticalΒ science. The feverfew (Tanacetum parthenium (L.) Schultz Bip) is one of the prospective species of the Aster family. Its chemicalΒ composition mainly consists of phenolic compounds and sesquiterpene lactones. According to the latest data of the foreignΒ sources feverfew herb phenolic compounds stipulate a prominent anti-inflammatory effect. This species is successfullyΒ used to treat the chronic inflammatory diseases of the connective tissue. Therefore, the determination of the qualitativeΒ composition and quantitative content in the samples of domestic feverfew raw material is actual.Aim. To determinate the qualitative composition and quantitative content of phenolic compounds in the feverfew herb.Materials and methods. The object was the feverfew herb collected in July 2017 on the territory of the BotanicalΒ garden of the National University of Pharmacy. The qualitative composition and quantitative content were determinatedΒ by the thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) methods.Results and discussion. Chlorogenic and cichoric acids zones, luteolin and luteolin7-glucoside in comparison withtheir zones of reference standards were identified by TLC method. 12 compounds were identified and determinated by HPLCΒ method. Hydroxycinnamic acids, namely 3,5-dicaffeoylquinic acid (1.575 %), 4,5-dicaffeoylquinic acid (1.308 %) andΒ chlorogenic acid (0.784 %) were accumulated in the feverfew herb in the greatest amount. Among flavonoids, apigenin-7-glucoside (0.071 %) and kaempferol (0.041 %) prevailed.Conclusions. For the first time the qualitative composition and quantitative content in the feverfew herb were determinatedΒ by TLC and HPLC methods. The high content of the phenolic compounds in the plant raw material attests toΒ the opportunity of feverfew herb standardization by such classes as hydroxycinnamic acids and flavonoids. The data obtainedΒ attest to the perspective creating a medicine with the high anti inflammatory activity based on the feverfew herb.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ. Поиск Π½ΠΎΠ²Ρ‹Ρ… Ρ€Π°ΡΡ‚ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… источников биологичСски Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… соСдинСний являСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ Π·Π°Π΄Π°Ρ‡Π΅ΠΉ фармацСвтичСской Π½Π°ΡƒΠΊΠΈ. Одним ΠΈΠ· пСрспСктивных Π²ΠΈΠ΄ΠΎΠ² сСмСйства АстровыС являСтся ΠΏΠΈΠΆΠΌΠ°Β Π΄Π΅Π²ΠΈΡ‡ΡŒΡ (Tanacetum parthenium (L.) Schultz Bip). Π•Π΅ химичСский состав прСдставлСн прСимущСствСнно Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹ΠΌΠΈ соСдинСниями ΠΈ сСсквитСрпСновыми Π»Π°ΠΊΡ‚ΠΎΠ½Π°ΠΌΠΈ. Богласно послСдним Π΄Π°Π½Π½Ρ‹ΠΌ иностранных ΠΈΡΡ‚ΠΎΡ‡Π½ΠΈΠΊΠΎΠ²Β Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Π΅ соСдинСния Ρ‚Ρ€Π°Π²Ρ‹ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ ΠΎΠ±ΡƒΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°ΡŽΡ‚ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΉ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ эффСкт.Β Π”Π°Π½Π½Ρ‹ΠΉ Π²ΠΈΠ΄ ΡƒΡΠΏΠ΅ΡˆΠ½ΠΎ ΠΏΡ€ΠΈΠΌΠ΅Π½ΡΡŽΡ‚ ΠΏΡ€ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ хроничСских Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ. Π‘Π»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎ, ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ качСствСнного состава ΠΈ количСствСнного содСрТания Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… соСдинСний Π² ΠΎΠ±Ρ€Π°Π·Ρ†Π°Ρ… отСчСствСнного ΡΡ‹Ρ€ΡŒΡ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ являСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌ.ЦСлью Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π±Ρ‹Π»ΠΎ исслСдованиС качСствСнного состава ΠΈ количСствСнного содСрТания Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… соСдинСний Π² Ρ‚Ρ€Π°Π²Π΅ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠžΠ±ΡŠΠ΅ΠΊΡ‚ΠΎΠΌ Π±Ρ‹Π»Π° Ρ‚Ρ€Π°Π²Π° ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ заготовлСнная Π² июлС 2017 Π³. Π½Π° тСрриторииБотаничСского сада ΠΠ°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ фармацСвтичСского унивСрситСта. ΠšΠ°Ρ‡Π΅ΡΡ‚Π²Π΅Π½Π½Ρ‹ΠΉ состав ΠΈ количСствСнноС содСрТаниС исслСдовали ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ тонкослойной Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ (Π’Π‘Π₯) ΠΈ высокоэффСктивной Тидкостной Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ (Π’Π­Π–Π₯).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π’Π‘Π₯ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π·ΠΎΠ½Ρ‹ Π½Π° ΡƒΡ€ΠΎΠ²Π½Π΅ Ρ…Π»ΠΎΡ€ΠΎΠ³Π΅Π½ΠΎΠ²ΠΎΠΉ ΠΈ Ρ†ΠΈΠΊΠΎΡ€ΠΈΠ΅Π²ΠΎΠΉ кислот, Π»ΡŽΡ‚Π΅ΠΎΠ»ΠΈΠ½Π°, Π»ΡŽΡ‚Π΅ΠΎΠ»ΠΈΠ½-7-Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ΄Π° Π² сравнСнии с Π·ΠΎΠ½Π°ΠΌΠΈ стандартных ΠΎΠ±Ρ€Π°Π·Ρ†ΠΎΠ². ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π’Π­Π–Π₯Β ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½ΠΎ ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΎ содСрТаниС 12 соСдинСний. Π’ наибольшСм количСствС Π² Ρ‚Ρ€Π°Π²Π΅ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ накапливались гидроксикоричныС кислоты, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ 3,5-дикафСоилхинная (1,575 %), 4,5-дикафСоилхинная (1,308 %) ΠΈ хлорогСновая (0,784 %) кислоты. Π‘Ρ€Π΅Π΄ΠΈ Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² количСствСнно ΠΏΡ€Π΅ΠΎΠ±Π»Π°Π΄Π°Π»ΠΈ Π°ΠΏΠΈΠ³Π΅Π½ΠΈΠ½-7-глюкозид (0,071 %) ΠΈ ΠΊΠ΅ΠΌΠΏΡ„Π΅Ρ€ΠΎΠ» (0,041 %).Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π’ΠΏΠ΅Ρ€Π²Ρ‹Π΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π’Π‘Π₯ ΠΈ Π’Π­Π–Π₯ исслСдованы качСствСнный состав ΠΈ количСствСнноС ΡΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… соСдинСний Π² Ρ‚Ρ€Π°Π²Π΅ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ. ВысокоС содСрТаниС Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ‹Ρ… соСдинСний Π² ΡΡ‹Ρ€ΡŒΠ΅ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΠ΅Ρ‚ ΠΎ возмоТности стандартизации Ρ‚Ρ€Π°Π²Ρ‹ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ ΠΏΠΎ Ρ‚Π°ΠΊΠΈΠΌ классам, ΠΊΠ°ΠΊ гидроксикоричныС кислоты ΠΈ Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄Ρ‹. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Π΄Π°Π½Π½Ρ‹Π΅ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΎ пСрспСктивности создания Π»Π΅ΠΊΠ°Ρ€ΡΡ‚Π²Π΅Π½Π½ΠΎΠ³ΠΎΒ Ρ€Π°ΡΡ‚ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ срСдства Π½Π° основС Ρ‚Ρ€Π°Π²Ρ‹ ΠΏΠΈΠΆΠΌΡ‹ Π΄Π΅Π²ΠΈΡ‡ΡŒΠ΅ΠΉ с высокой ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ–ΡΡ‚ΡŒ. ΠŸΠΎΡˆΡƒΠΊ Π½ΠΎΠ²ΠΈΡ… рослинних Π΄ΠΆΠ΅Ρ€Π΅Π» Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ Ρ” Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡŽ Π·Π°Π΄Π°Ρ‡Π΅ΡŽ Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½ΠΎΡ— Π½Π°ΡƒΠΊΠΈ. Одним Ρ–Π· пСрспСктивних Π²ΠΈΠ΄Ρ–Π² Ρ€ΠΎΠ΄ΠΈΠ½ΠΈ Айстрові Ρ” ΠΌΠ°Ρ€ΡƒΠ½Π° Π΄Ρ–Π²ΠΎΡ‡Π° (Tanacetum parthenium (L.)Β Schultz Bip.). Π‡Ρ— Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΠΉ склад прСдставлСний ΠΏΠ΅Ρ€Π΅Π²Π°ΠΆΠ½ΠΎ Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½ΠΈΠΌΠΈ Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½Π°ΠΌΠΈ Ρ‚Π° сСсквітСрпСновими Π»Π°ΠΊΡ‚ΠΎΠ½Π°ΠΌΠΈ. Π—Π° останніми Π΄Π°Π½ΠΈΠΌΠΈ Π·Π°ΠΊΠΎΡ€Π΄ΠΎΠ½Π½ΠΈΡ… Π΄ΠΆΠ΅Ρ€Π΅Π» Ρ–Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†Ρ–Ρ— Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½Ρ– сполуки Ρ‚Ρ€Π°Π²ΠΈ ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ— Π·ΡƒΠΌΠΎΠ²Π»ΡŽΡŽΡ‚ΡŒ Π²ΠΈΡ€Π°ΠΆΠ΅Π½ΠΈΠΉ ΠΏΡ€ΠΎΡ‚ΠΈΠ·Π°ΠΏΠ°Π»ΡŒΠ½ΠΈΠΉ Π΅Ρ„Π΅ΠΊΡ‚. Π”Π°Π½ΠΈΠΉ Π²ΠΈΠ΄ ΡƒΡΠΏΡ–ΡˆΠ½ΠΎ Π·Π°ΡΡ‚ΠΎΡΠΎΠ²ΡƒΡŽΡ‚ΡŒ ΠΏΡ€ΠΈ Π»Ρ–ΠΊΡƒΠ²Π°Π½Π½Ρ– Ρ…Ρ€ΠΎΠ½Ρ–Ρ‡Π½ΠΈΡ… Π·Π°ΠΏΠ°Π»ΡŒΠ½ΠΈΡ…Π·Π°Ρ…Π²ΠΎΡ€ΡŽΠ²Π°Π½ΡŒ сполучної Ρ‚ΠΊΠ°Π½ΠΈΠ½ΠΈ. ΠžΡ‚ΠΆΠ΅, дослідТСння якісного складу Ρ‚Π° ΠΊΡ–Π»ΡŒΠΊΡ–ΡΠ½ΠΎΠ³ΠΎ вмісту Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½Β Ρƒ Π·Ρ€Π°Π·ΠΊΠ°Ρ… вітчизняної сировини Ρ” Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΠΌ.ΠœΠ΅Ρ‚ΠΎΡŽ Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ Π±ΡƒΠ»ΠΎ дослідити якісний склад Ρ– ΠΊΡ–Π»ΡŒΠΊΡ–ΡΠ½ΠΈΠΉ вміст Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½ΠΈΡ… сполук Ρƒ Ρ‚Ρ€Π°Π²Ρ– ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ—.ΠœΠ°Ρ‚Π΅Ρ€Ρ–Π°Π»ΠΈ Ρ‚Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈ. ΠžΠ±β€™Ρ”ΠΊΡ‚ΠΎΠΌ Π±ΡƒΠ»Π° Ρ‚Ρ€Π°Π²Π° ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ—, Π·Π°Π³ΠΎΡ‚ΠΎΠ²Π»Π΅Π½ΠΎΡ— Ρƒ Π»ΠΈΠΏΠ½Ρ– 2017 Ρ€. Π½Π° Ρ‚Π΅Ρ€ΠΈΡ‚ΠΎΡ€Ρ–Ρ— Π‘ΠΎΡ‚Π°Π½Ρ–Ρ‡Π½ΠΎΠ³ΠΎ саду ΠΠ°Ρ†Ρ–ΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ унівСрситСту. Якісний склад Ρ‚Π° ΠΊΡ–Π»ΡŒΠΊΡ–ΡΠ½ΠΈΠΉ вміст дослідТували мСтодом Ρ‚ΠΎΠ½ΠΊΠΎΡˆΠ°Ρ€ΠΎΠ²ΠΎΡ— Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ–Ρ— (Π’Π¨Π₯) Ρ‚Π° високоСфСктивної Ρ€Ρ–Π΄ΠΈΠ½Π½ΠΎΡ— Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ–Ρ— (Π’Π•Π Π₯).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π’Π¨Π₯ Ρ–Π΄Π΅Π½Ρ‚ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½Ρ– Π·ΠΎΠ½ΠΈ Π½Π° Ρ€Ρ–Π²Π½Ρ– Ρ…Π»ΠΎΡ€ΠΎΠ³Π΅Π½ΠΎΠ²ΠΎΡ— Ρ‚Π° цикорієвоїкислот, Π»ΡŽΡ‚Π΅ΠΎΠ»Ρ–Π½Ρƒ, Π»ΡŽΡ‚Π΅ΠΎΠ»Ρ–Π½-7-Π³Π»Ρ–ΠΊΠΎΠ·ΠΈΠ΄Ρƒ Ρƒ порівнянні Ρ–Π· Π·ΠΎΠ½Π°ΠΌΠΈ стандартних Π·Ρ€Π°Π·ΠΊΡ–Π². ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π’Π•Π Π₯ Ρ–Π΄Π΅Π½Ρ‚ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½ΠΎ Ρ‚Π° Π²ΠΈΠ·Π½Π°Ρ‡Π΅Π½ΠΎ вміст 12 сполук. Π£ Π½Π°ΠΉΠ±Ρ–Π»ΡŒΡˆΡ–ΠΉ ΠΊΡ–Π»ΡŒΠΊΠΎΡΡ‚Ρ– Ρƒ Ρ‚Ρ€Π°Π²Ρ– ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ— Π½Π°ΠΊΠΎΠΏΠΈΡ‡ΡƒΠ²Π°Π»ΠΈΡΡŒ гідроксикоричні кислоти, Π° самС 3,5-Π΄ΠΈΠΊΠ°Ρ„Π΅ΠΎΡ—Π»ΠΎΡ…Ρ–Π½Π½Π° (1,575 %), 4,5-Π΄ΠΈΠΊΠ°Ρ„Π΅ΠΎΡ—Π»ΠΎΡ…Ρ–Π½Π½Π° (1,308 %) Ρ‚Π° Ρ…Π»ΠΎΡ€ΠΎΠ³Π΅Π½ΠΎΠ²Π° (0,784 %) кислоти. Π‘Π΅Ρ€Π΅Π΄ Ρ„Π»Π°Π²ΠΎΠ½ΠΎΡ—Π΄Ρ–Π² ΠΊΡ–Π»ΡŒΠΊΡ–ΡΠ½ΠΎ ΠΏΠ΅Ρ€Π΅Π²Π°ΠΆΠ°Π»ΠΈ Π°ΠΏΡ–Π³Π΅Π½Ρ–Π½-7-глюкозид (0,071 %) Ρ‚Π° ΠΊΠ΅ΠΌΠΏΡ„Π΅Ρ€ΠΎΠ» (0,041 %).Висновки. Π’ΠΏΠ΅Ρ€ΡˆΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π’Π¨Π₯ Ρ‚Π° Π’Π•Π Π₯ дослідТСно якісний склад Ρ‚Π° ΠΊΡ–Π»ΡŒΠΊΡ–ΡΠ½ΠΈΠΉ вміст Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½ΠΈΡ… сполуку Ρ‚Ρ€Π°Π²Ρ– ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ—. Високий вміст Ρ„Π΅Π½ΠΎΠ»ΡŒΠ½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ Ρƒ сировині ΡΠ²Ρ–Π΄Ρ‡ΠΈΡ‚ΡŒ ΠΏΡ€ΠΎ ΠΌΠΎΠΆΠ»ΠΈΠ²Ρ–ΡΡ‚ΡŒ стандартизації трави ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ— Π·Π° Ρ‚Π°ΠΊΠΈΠΌΠΈ класами, як гідроксикоричні кислоти Ρ‚Π° Ρ„Π»Π°Π²ΠΎΠ½ΠΎΡ—Π΄ΠΈ. ΠžΡ‚Ρ€ΠΈΠΌΠ°Π½Ρ– Π΄Π°Π½Ρ– ΡΠ²Ρ–Π΄Ρ‡Π°Ρ‚ΡŒΒ ΠΏΡ€ΠΎ ΠΏΠ΅Ρ€ΡΠΏΠ΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ створСння Π»Ρ–ΠΊΠ°Ρ€ΡΡŒΠΊΠΎΠ³ΠΎ рослинного засобу Π½Π° основі Ρ‚Ρ€Π°Π²ΠΈ ΠΌΠ°Ρ€ΡƒΠ½ΠΈ Π΄Ρ–Π²ΠΎΡ‡ΠΎΡ— Π· високою ΠΏΡ€ΠΎΡ‚ΠΈΠ·Π°ΠΏΠ°Π»ΡŒΠ½ΠΎΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŽ
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