Worldline algorithms for Casimir configurations

We present improved worldline numerical algorithms for high-precision calculations of Casimir interaction energies induced by scalar-field fluctuations with Dirichlet boundary conditions for various Casimir geometries. Significant reduction of numerical cost is gained by exploiting the symmetries of the worldline ensemble in combination with those of the configurations. This facilitates high-precision calculations on standard PCs or small clusters. We illustrate our strategies using the experimentally most relevant sphere-plate and cylinder-plate configuration. We compute Casimir curvature effects for a wide parameter range, revealing the tight validity bounds of the commonly used proximity force approximation (PFA). We conclude that data analysis of future experiments aiming at a precision of 0.1% must no longer be based on the PFA. Revisiting the parallel-plate configuration, we find a mapping between the D-dimensional Casimir energy and properties of a random-chain polymer ensemble.Comment: 23 pages, 9 figure

Casimir effect for curved geometries: PFA validity limits

We compute Casimir interaction energies for the sphere-plate and cylinder-plate configuration induced by scalar-field fluctuations with Dirichlet boundary conditions. Based on a high-precision calculation using worldline numerics, we quantitatively determine the validity bounds of the proximity force approximation (PFA) on which the comparison between all corresponding experiments and theory are based. We observe the quantitative failure of the PFA on the 1% level for a curvature parameter a/R > 0.00755. Even qualitatively, the PFA fails to predict reliably the correct sign of genuine Casimir curvature effects. We conclude that data analysis of future experiments aiming at a precision of 0.1% must no longer be based on the PFA.Comment: 4 pages, 4 figure

Casimir interaction between normal or superfluid grains in the Fermi sea

We report on a new force that acts on cavities (literally empty regions of space) when they are immersed in a background of non-interacting fermionic matter fields. The interaction follows from the obstructions to the (quantum mechanical) motions of the fermions caused by the presence of bubbles or other (heavy) particles in the Fermi sea, as, for example, nuclei in the neutron sea in the inner crust of a neutron star or superfluid grains in a normal Fermi liquid. The effect resembles the traditional Casimir interaction between metallic mirrors in the vacuum. However, the fluctuating electromagnetic fields are replaced by fermionic matter fields. We show that the fermionic Casimir problem for a system of spherical cavities can be solved exactly, since the calculation can be mapped onto a quantum mechanical billiard problem of a point-particle scattered off a finite number of non-overlapping spheres or disks. Finally we generalize the map method to other Casimir systems, especially to the case of a fluctuating scalar field between two spheres or a sphere and a plate under Dirichlet boundary conditions.Comment: 8 pages, 2 figures, submitted to the Proceedings of QFEXT'05, Barcelona, Sept. 5-9, 200

Casimir effect: Edges and diffraction

The Casimir effect refers to the existence of a macroscopic force between conducting plates in vacuum due to quantum fluctuations of fields. These forces play an important role, among other things, in the design of nano-scale mechanical devices. Accurate experimental observations of this phenomenon have motivated the development of new theoretical approaches in dealing with the effects of different geometries, temperature etc. In this talk, I will focus on a new method we have developed in calculating the contribution to the Casimir effect due to diffraction from edges and holes in different geometries, at zero and at finite temperature.Comment: 11 pages, 2 figures. Talk at the QTS7 conference, Prague, 2011; to appear in the proceeding

Geothermal Casimir Phenomena

We present first worldline analytical and numerical results for the nontrivial interplay between geometry and temperature dependencies of the Casimir effect. We show that the temperature dependence of the Casimir force can be significantly larger for open geometries (e.g., perpendicular plates) than for closed geometries (e.g., parallel plates). For surface separations in the experimentally relevant range, the thermal correction for the perpendicular-plates configuration exhibits a stronger parameter dependence and exceeds that for parallel plates by an order of magnitude at room temperature. This effect can be attributed to the fact that the fluctuation spectrum for closed geometries is gapped, inhibiting the thermal excitation of modes at low temperatures. By contrast, open geometries support a thermal excitation of the low-lying modes in the gapless spectrum already at low temperatures.Comment: 8 pages, 3 figures, contribution to QFEXT07 proceedings, v2: discussion switched from Casimir energy to Casimir force, new analytical results included, matches JPhysA versio

Casimir forces and non-Newtonian gravitation

The search for non-relativistic deviations from Newtonian gravitation can lead to new phenomena signalling the unification of gravity with the other fundamental interactions. Various recent theoretical frameworks indicate a possible window for non-Newtonian forces with gravitational coupling strength in the micrometre range. The major expected background in the same range is attributable to the Casimir force or variants of it if dielectric materials, rather than conducting ones, are considered. Here we review the measurements of the Casimir force performed so far in the micrometre range and how they determine constraints on non-Newtonian gravitation, also discussing the dominant sources of false signals. We also propose a geometry-independent parameterization of all data in terms of the measurement of the constant c. Any Casimir force measurement should lead, once all corrections are taken into account, to a determination of the constant c which, in order to assess the accuracy of the measurement, can be compared with its more precise value known through microscopic measurements. Although the last decade of experiments has resulted in solid demonstrations of the Casimir force, the situation is not conclusive with respect to being able to discover new physics. Future experiments and novel phenomenological analysis will be necessary to discover non-Newtonian forces or to push the window for their possible existence into regions of the parameter space which theoretically appear unnatural.Comment: Also available at http://www.iop.org/EJ/abstract/1367-2630/8/10/23

Thermal corrections to the Casimir effect

The Casimir effect, reflecting quantum vacuum fluctuations in the electromagnetic field in a region with material boundaries, has been studied both theoretically and experimentally since 1948. The forces between dielectric and metallic surfaces both plane and curved have been measured at the 10 to 1 percent level in a variety of room-temperature experiments, and remarkable agreement with the zero-temperature theory has been achieved. In fitting the data various corrections due to surface roughness, patch potentials, curvature, and temperature have been incorporated. It is the latter that is the subject of the present article. We point out that, in fact, no temperature dependence has yet been detected, and that the experimental situation is still too fluid to permit conclusions about thermal corrections to the Casimir effect. Theoretically, there are subtle issues concerning thermodynamics and electrodynamics which have resulted in disparate predictions concerning the nature of these corrections. However, a general consensus has seemed to emerge that suggests that the temperature correction to the Casimir effect is relatively large, and should be observable in future experiments involving surfaces separated at the few micrometer scale.Comment: 21 pages, 9 eps figures, uses iopart.cls. Final version to be published in New Journal of Physics, contains Conclusion and clarified remark

Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling

Erythroid development requires the action of erythropoietin (EPO) on committed progenitors to match red cell output to demand. In this process, iron acts as a critical cofactor, with iron deficiency blunting EPO-responsiveness of erythroid progenitors. Aconitase enzymes have recently been identified as possible signal integration elements that couple erythropoiesis with iron availability. In the current study, a regulatory role for aconitase during erythropoiesis was ascertained using a direct inhibitory strategy.In C57BL/6 mice, infusion of an aconitase active-site inhibitor caused a hypoplastic anemia and suppressed responsiveness to hemolytic challenge. In a murine model of polycythemia vera, aconitase inhibition rapidly normalized red cell counts, but did not perturb other lineages. In primary erythroid progenitor cultures, aconitase inhibition impaired proliferation and maturation but had no effect on viability or ATP levels. This inhibition correlated with a blockade in EPO signal transmission specifically via ERK, with preservation of JAK2-STAT5 and Akt activation. Correspondingly, a physical interaction between ERK and mitochondrial aconitase was identified and found to be sensitive to aconitase inhibition.Direct aconitase inhibition interferes with erythropoiesis in vivo and in vitro, confirming a lineage-selective regulatory role involving its enzymatic activity. This inhibition spares metabolic function but impedes EPO-induced ERK signaling and disturbs a newly identified ERK-aconitase physical interaction. We propose a model in which aconitase functions as a licensing factor in ERK-dependent proliferation and differentiation, thereby providing a regulatory input for iron in EPO-dependent erythropoiesis. Directly targeting aconitase may provide an alternative to phlebotomy in the treatment of polycythemia vera

Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes

The proinflammatory cytokine TNFα fails to provoke cell death in isolated hepatocytes but has been implicated in hepatocyte apoptosis during liver diseases associated with chronic inflammation. Recently, we showed that TNFα is able to sensitize primary murine hepatocytes cultured on collagen to Fas ligand-induced apoptosis and presented a mathematical model of the sensitizing effect. Here, we analyze how TNFα induces apoptosis in combination with the transcriptional inhibitor actinomycin D (ActD). Accumulation of reactive oxygen species (ROS) in response to TNFR activation turns out to be critical for sustained activation of JNK which then triggers mitochondrial pathway-dependent apoptosis. In addition, the amount of JNK is strongly upregulated in a ROS-dependent way. In contrast to TNFα plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch-mediated cFLIP degradation and predominantly caspase-8 activation is not involved. Time-resolved data of the respective pro- and antiapoptotic factors are obtained and subjected to mathematical modeling. On the basis of these data we developed a mathematical model which reproduces the complex interplay regulating the phosphorylation status of JNK and generation of ROS. This model was fully integrated with our model of TNFα/Fas ligand sensitizing as well as with a published NF-κB-model. The resulting comprehensive model delivers insight in the dynamical interplay between the TNFα and FasL pathways, NF-κB and ROS and gives an example for successful model integration