Oxytocin at physiological concentrations evokes adrenocorticotropin (ACTH) release from corticotrophs by increasing intracellular free calcium mobilized mainly from intracellular stores. Oxytocin displays synergistic or additive effects on ACTH-releasing factor or arginine vasopressin-induced ACTH secretion, respectively

The potency of oxytocin (OT) in evoking ACTH secretion by isolated, superfused rat adenohypophyseal corticotrophs and its enhancement by CRF and arginine vasopressin (AVP) were analyzed. Each secretagogue effectively released ACTH from adenohypophyseal cells when added separately in pulsatile fashion in physiological concentrations based on hypophyseal portal blood (OT, 10 nM; AVP, 0.5 nM; CRF, 0.1 nM). OT released ACTH at concentrations as low as 1 nM. Moreover, a dose- response relationship up to 10 microM was revealed. Combinations of a constant amount of CRF (0.1 nM) with increasing concentrations of OT exerted a synergistic effect on ACTH release. In contrast, OT given in various concentrations in combination with AVP (0.5 nM) produced an additive effect on ACTH release. To study the mechanism of action of OT on ACTH secretion, cytosolic free calcium levels in single pituitary cells exposed to OT or AVP were measured using the calcium-sensitive fluorescent indicator Fura-2. Corticotrophs among mixed adenohypophyseal cell types in the primary cultures were identified by immunocytochemistry. More than 500 cells were individually stimulated with OT or AVP. Basal cytosolic free calcium levels ranged between 80- 130 nM free calcium. The addition of 100 nM OT or 1 microM AVP increased the cytosolic free calcium concentration within 3 sec to values ranging from 500-800 nM. An increase in intracellular calcium ranging from 200-500 nM due to OT could still be observed after extracellular calcium depletion. Taken together, our data demonstrate that physiological concentrations of OT stimulate ACTH secretion, independent of the other ACTH secretagogues, by mobilizing calcium mainly from intracellular stores

Interpreting experimental bounds on D^0 - \bar{D^0} mixing in the presence of CP violation

We analyse the most recent experimental data regarding D^0 - \bar{D^0} mixing, allowing for CP violation. We focus on the dispersive part of the mixing amplitude, M^D_{12}, which is sensitive to new physics contributions. We obtain a constraint on the mixing amplitude: |M^D_{12}| < 6.2\times 10^{-11} MeV at 95% C.L. . This constraint is weaker by a factor of about three than the one which is obtained when no CP violation is assumed.Comment: 9 pages, revtex4; One reference updated, one reference added, footnote 3 correcte

Microscopic theory of quadrupolar ordering in TmTe

We have calculated the crystal electric field of TmTe (T>T_Q) and have obtained that the ground state of a Tm 4f hole is the $\Gamma_7$ doublet in agreement with Mossbauer experiments. We study the quadrupole interactions arising from quantum transitions of 4f holes of Tm. An effective attraction is found at the L point of the Brillouin zone, $\vec{q}_L$. Assuming that the quadrupolar condensation involves a single arm of $\vec{q}_L$ we show that there are two variants for quadrupole ordering which are described by the space groups C2/c and C2/m. The Landau free energy is derived in mean-field theory. The phase transition is of second order. The corresponding quadrupole order parameters are combinations of $T_{2g}$ and $E_g$ components. The obtained domain structure is in agreement with observations from neutron diffraction studies for TmTe. Calculated lattice distortions are found to be different for the two variants of quadrupole ordering. We suggest to measure lattice displacements in order to discriminate between those two structures.Comment: 10 pages, 2 figures, 5 tables; accepted by PR

Tau and Charm physics highlights

In tau physics, we are at the frontier between the completion of the LEP program and the start of analyses from b-factories, which are expected to produce results in the coming years. Nice results from CLEO are steadily delivered in the meantime. For charm, impressive progress have been achieved by fixed target experiments in the search for CP violation and D^0 - \bar D^0 oscillations. First results from b-factories demonstrate the power of these facilities in such areas. The novel measurement of the D* width by CLEO happens to be rather different from current expectations. The absence of a charm factory explains the lack or the very slow progress in the absolute scale determinations for charm decays.Comment: "Typos corrected and references added

Pulsar Constraints on Neutron Star Structure and Equation of State

With the aim of constraining the structural properties of neutron stars and the equation of state of dense matter, we study sudden spin-ups, glitches, occurring in the Vela pulsar and in six other pulsars. We present evidence that glitches represent a self-regulating instability for which the star prepares over a waiting time. The angular momentum requirements of glitches in Vela indicate that at least 1.4% of the star's moment of inertia drives these events. If glitches originate in the liquid of the inner crust, Vela's `radiation radius' must exceed ~12 km for a mass of 1.4 solar masses. Observational tests of whether other neutron stars obey this constraint will be possible in the near future.Comment: 5 pages, including figures. To appear in Physical Review Letter

On Bubble Growth and Droplet Decay in Cosmological Phase Transitions

We study spherically symmetric bubble growth and droplet decay in first order cosmological phase transitions, using a numerical code including both the complete hydrodynamics of the problem and a phenomenological model for the microscopic entropy producing mechanism at the phase transition surface. The small-scale effects of finite wall width and surface tension are thus consistently incorporated. We verify the existence of the different hydrodynamical growth modes proposed recently and investigate the problem of a decaying quark droplet in the QCD phase transition. We find that the decaying droplet leaves behind no rarefaction wave, so that any baryon number inhomogeneity generated previously should survive the decay.Comment: 10 pages (revtex), 10 figures as uuencoded postscrip