3-(Benzo[b]thien-2-yl)-5,6-dihydro-1,4,2-oxathiazine 4-Oxide

The title compound, C₁₁H₉NO₂S₂, is a potent material preservative and contains the 1,4,2-oxathiazine ring system in a half-chair conformation with the methylene C atoms 0.510 (3) and -0.367 (3) Å from the plane of the other four oxathiazine ring atoms

The Impact of Urinary Tract Infections in an Australian Setting: A Multi-State Model

The emergence of antimicrobial resistance is of particular concern with respect to urinary tract infections, since the majority of causative agents are Gram negative bacteria. Healthcare-associated urinary tract infections (HAUTIs) are frequently associated with instrumentation of the urinary tract, specifically within dwelling catheters

Genetic fat – bullet proofing the Merino ewe

Merino ewes are the backbone of the Australian sheep industry and this is likely to be the case for some time. Stocking rate will remain a key profit driver in Merino enterprises and to maintain or improve profitability producers will need to continually adapt their production systems to deal with even larger changes in feed supply between seasons and years. The reproductive performance of the Merino ewe also needs to improve, largely through improving the survival of twin born lambs, to rebuild flock numbers and meet market demand for lamb and sheep meat. Increasing both stocking rates and reproductive performance need to be achieved in the context of producers wanting to run more sheep per person with less intervention and increased consumer demand for welfare friendly products. Improving genetics and matching sheep genotype to the production and management system will inevitably become more important. We believe this will include defining traits to more easily identify Merino sheep that are more robust, that lose less liveweight when faced with sub-optimum nutrition and that produce more progeny with higher survival rates both pre- and post-weaning. Increasing genetic fat is the prime candidate for increasing the robustness of Merino ewes and their progeny as the storage and mobilisation of fat is an important mechanism for all animals to cope with fluctuating environments. Fat is stored during favourable times and then mobilised to provide energy for fundamental functions when requirements exceed supply, such as during periods of limited nutrition or during late pregnancy and lactation. The amount of fat stored in fat depots in sheep can be increased by selection for higher subcutaneous fat depth, using Australian Sheep Breeding Values (ASBVs) from MERINOSELECT. However, from a genetic perspective, reducing the fatness of lamb to improve its appeal to the consumer has resulted in a general focus on selection for less fat in Australian sheep breeds. Merino sheep have also become leaner as a result of selection for higher fleece weights and the genetic association between higher fleece weight and reduced fatness (Huisman and Brown 2009). Defining the true value of fat requires an understanding of the effect it has on the value of lamb carcasses as well as its effects on the productivity of the sheep production system in different environments. In this paper we have reviewed published papers and our own unpublished work to test the hypothesis that Merino sheep that are genetically fatter will have improved performance especially under more restricted nutritional conditions

Post-Agricultural Succession in El PetÉn, Guatemala

We compared post-agricultural succession across the range of farming activities practiced in Guatemala's northern lowlands: agroforestry, swidden, ranching, and input-intensive monocultures. At 10 sites over 13 to 40 months we assessed the following characteristics of trees and shrubs that were>1 cm diameter at breast height: height, basal-area accumulation, recruitment of all individuals and fleshy-fruited individuals, and accumulation of all species and fleshy-fruited species. Succession, as measured by all these response variables except height, was dramatically faster on agroforestry and swidden sites than on pastures or input-intensive monocultures. Overall recruitment was faster for swiddens than for agroforests, but other response variables did not differ significantly between the two treatments. Regression results suggest that initial ground cover by herbs inhibited recruitment of woody colonists. The significant positive coefficient for initial basal area and the significant negative coefficient for distance from forest for accumulation of both fleshy-fruited individuals and species are probably explained by the behavioral responses of seed-dispersing animals. Our results suggest that the conservation strategy of discouraging swidden agriculture in favor of sedentary, input-intensive agriculture to relieve pressure on old-growth forest may be counterproductive over the long term.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75095/1/j.1523-1739.2003.01265.x.pd

Structure of 1-(3-butynyl)pyridinium p-toluenesulfonate

The 1-(3-butynyl)pyridinium p-toluenesulfonate salt, C9H10N+.CTHTO3S -, contains a C--H...O hydrogen bond between the acetylenic H atom of the cation and a sulfonate O atom of the anion in the solid state [C...O 3.32 (1), H...O 2.49 A, C--H...O 159°]. The X-ray analysis was complicated by disorder in both the cation and anion. A major (85%) and a minor (15%) component of the 1-(3-butynyl)pyridinium cation are present, both occuping the same volume element in the lattice. The methyl H atoms and sulfonate O atoms of the p-toluenesulfonate anion are disordered over two orientations

The experience of young people receiving cognitive behavioural therapy for major depression : A qualitative study

Aim Major depressive disorder (MDD) has far reaching impacts for young people, their families and society. Cognitive behavioural therapy (CBT) is one of the first-line treatments for young people experiencing MDD; however, there is limited research examining how young people with MDD experience CBT. The aim of this study was to explore their experience and their views of this intervention. Methods We employed a qualitative research design, with semi-structured interviews and thematic analysis. Eight participants aged between 17 and 24 years who received CBT for MDD in a randomized controlled trial were recruited. Results Five themes were identified: the importance of relationship with clinician; the range of useful components within CBT; the ability for CBT to accommodate different techniques and presenting issues; the importance of checking in with clients during the process of therapy; and the impacts of MDD on therapy. Conclusions The findings highlight the importance of clinicians having a youth friendly and collaborative approach that allows a modular delivery of a range of CBT techniques to suit the client's presenting issue and formulation. There is a need to continually check how young people are responding to interventions, and to be aware of potential cognitive deficits and adjust therapy accordingly. This is a small study that provides insight into how young people with MDD experience CBT and avenues to explore for tailoring provision of CBT to enhance the therapeutic experience for this population

Use of mental simulations to change theory of planned behaviour variables

Objectives. The predictive validity of the theory of planned behaviour iswell established, but much less is known about: (a) whether there are causal relationships between key components of the model and (b) how to go about changing the theory of planned behaviour variables. This study tested the ability of outcome and process simulations to change variables specified in the theory of planned behaviour in relation to blood donation. Design. Participants (N ¼ 146) were randomized to one of four conditions: outcome simulation only, process simulation only, process-plus-outcome simulation and a distractor control condition. The dependent variables were state anxiety, and intention attitude, subjective norm and perceived control from the theory of planned behaviour. Methods. Participants were asked to empty their mind and visualize themselves: (a) after donating blood (outcome manipulation), (b) preparing to donate blood (process manipulation), (c) both preparing to donate blood and after having donated blood (process-plus-outcome manipulation) or (d) both preparing to get a high mark and after having got a high mark on their course (control condition). Following mental rehearsal, participants completed the dependent variables. Results. There were no main effects of outcome simulation, but process simulation successfully increased intention, subjective norm and perceived control. There was also a significant outcome simulation x process simulation interaction for attitude. The effect of the process manipulation on intention was mediated by subjective norm and perceived control. Conclusions. The findings show promise for the use of mental simulations in changing cognitions and further research is required to extend the present findings to other health behaviours.</p

RegenBase: a knowledge base of spinal cord injury biology for translational research.

Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, data and domain knowledge are locked in the largely unstructured text of scientific publications, making large scale integration with existing bioinformatics resources and subsequent analysis infeasible. The lack of standard reporting for experiment variables and results also makes experiment replicability a significant challenge. To address these challenges, we have developed RegenBase, a knowledge base of SCI biology. RegenBase integrates curated literature-sourced facts and experimental details, raw assay data profiling the effect of compounds on enzyme activity and cell growth, and structured SCI domain knowledge in the form of the first ontology for SCI, using Semantic Web representation languages and frameworks. RegenBase uses consistent identifier schemes and data representations that enable automated linking among RegenBase statements and also to other biological databases and electronic resources. By querying RegenBase, we have identified novel biological hypotheses linking the effects of perturbagens to observed behavioral outcomes after SCI. RegenBase is publicly available for browsing, querying and download.Database URL:http://regenbase.org