Specialization of the rostral prefrontal cortex for distinct analogy processes

Analogical reasoning is central to learning and abstract thinking. It involves using a more familiar situation (source) to make inferences about a less familiar situation (target). According to the predominant cognitive models, analogical reasoning includes 1) generation of structured mental representations and 2) mapping based on structural similarities between them. This study used functional magnetic resonance imaging to specify the role of rostral prefrontal cortex (PFC) in these distinct processes. An experimental paradigm was designed that enabled differentiation between these processes, by temporal separation of the presentation of the source and the target. Within rostral PFC, a lateral subregion was activated by analogy task both during study of the source (before the source could be compared with a target) and when the target appeared. This may suggest that this subregion supports fundamental analogy processes such as generating structured representations of stimuli but is not specific to one particular processing stage. By contrast, a dorsomedial subregion of rostral PFC showed an interaction between task (analogy vs. control) and period (more activated when the target appeared). We propose that this region is involved in comparison or mapping processes. These results add to the growing evidence for functional differentiation between rostral PFC subregions

Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19

COVID-19 is now established to be associated with a thrombotic phenomenon, now called COVID-19 associated coagulopathy (CAC). Anti-Endothelial Cell Antibodies (AECA) are a heterogenous group of autoantibodies targeting various endothelial cell antigens or antigens adhering to endothelial cells, They are commonly observed in a variety of auto-immune and rheumatologic conditions, and were observed in patients with the severe acute respiratory syndrome (SARS) in 2005. We aimed to assess AECA status in patients with COVID-19 and their potential contributing role to endothelial injury and CAC. AECA identification was a relatively infrequent finding in COVID-19 patients on admission, and their presence, albeit in only 2/33 patients, was not associated with disease severity. However, as the autoantibodies were only measured at admission, we cannot exclude the possibility of pathogenic AECA developing later in the course of diseaseFurther studies using additional methods are needed to evaluate the presence and potential pathogenic role of AECA in later stages of COVID-19

Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections

Author summary Neglected tropical diseases (NTDs) affecting humans and/or domestic animals severely impair the socio-economic development of endemic areas. One of these diseases, animal trypanosomosis, affects livestock and is caused by the parasites of the Trypanosoma genus. The most widespread causative agent of animal trypanosomosis is T. evansi, which is found in large parts of the world (Africa, Asia, South America, Middle East, and the Mediterranean). Proper control and treatment of the disease requires the availability of reliable and sensitive diagnostic tools. DNA-based detection techniques are powerful and versatile in the sense that they can be tailored to achieve a high specificity and usually allow the reliable detection of low amounts of parasite genetic material. However, many DNA-based methodologies (such as PCR) require trained staff and well-equipped laboratories, which is why the research community has actively investigated in developing amplification strategies that are simple, fast, cost-effective and are suitable for use in minimally equipped laboratories and field settings. In this paper, we describe the development of a diagnostic test under a dipstick format for the specific detection of T. evansi, based on a DNA amplification principle (Recombinase Polymerase Amplification aka RPA) that meets the above-mentioned criteria. Background Animal trypanosomosis caused by Trypanosoma evansi is known as "surra" and is a widespread neglected tropical disease affecting wild and domestic animals mainly in South America, the Middle East, North Africa and Asia. An essential necessity for T. evansi infection control is the availability of reliable and sensitive diagnostic tools. While DNA-based PCR detection techniques meet these criteria, most of them require well-trained and experienced users as well as a laboratory environment allowing correct protocol execution. As an alternative, we developed a recombinase polymerase amplification (RPA) test for Type A T. evansi. The technology uses an isothermal nucleic acid amplification approach that is simple, fast, cost-effective and is suitable for use in minimally equipped laboratories and even field settings. Methodology/Principle findings An RPA assay targeting the T. evansi RoTat1.2 VSG gene was designed for the DNA-based detection of T. evansi. Comparing post-amplification visualization by agarose gel electrophoresis and a lateral flow (LF) format reveals that the latter displays a higher sensitivity. The RPA-LF assay is specific for RoTat1.2-expressing strains of T. evansi as it does not detect the genomic DNA of other trypanosomatids. Finally, experimental mouse infection trials demonstrate that the T. evansi specific RPA-LF can be employed as a test-of-cure tool

CPT symmetry and antimatter gravity in general relativity

The gravitational behavior of antimatter is still unknown. While we may be confident that antimatter is self-attractive, the interaction between matter and antimatter might be either attractive or repulsive. We investigate this issue on theoretical grounds. Starting from the CPT invariance of physical laws, we transform matter into antimatter in the equations of both electrodynamics and gravitation. In the former case, the result is the well-known change of sign of the electric charge. In the latter, we find that the gravitational interaction between matter and antimatter is a mutual repulsion, i.e. antigravity appears as a prediction of general relativity when CPT is applied. This result supports cosmological models attempting to explain the Universe accelerated expansion in terms of a matter-antimatter repulsive interaction.Comment: 6 pages, to be published in EPL (http://epljournal.edpsciences.org/

Lumped element kinetic inductance detectors maturity for space-borne instruments in the range between 80 and 180 GHz

This work intends to give the state-of-the-art of our knowledge of the performance of LEKIDs at millimetre wavelengths (from 80 to 180~GHz). We evaluate their optical sensitivity under typical background conditions and their interaction with ionising particles. Two LEKID arrays, originally designed for ground-based applications and composed of a few hundred pixels each, operate at a central frequency of 100, and 150~GHz ($\Delta \nu / \nu$ about 0.3). Their sensitivities have been characterised in the laboratory using a dedicated closed-circle 100~mK dilution cryostat and a sky simulator, allowing for the reproduction of realistic, space-like observation conditions. The impact of cosmic rays has been evaluated by exposing the LEKID arrays to alpha particles ($^{241}$Am) and X sources ($^{109}$Cd) with a readout sampling frequency similar to the ones used for Planck HFI (about 200~Hz), and also with a high resolution sampling level (up to 2~MHz) in order to better characterise and interpret the observed glitches. In parallel, we have developed an analytical model to rescale the results to what would be observed by such a LEKID array at the second Lagrangian point.Comment: 7 pages, 2 tables, 13 figure

Animal health strategies in organic and conventional meat sheep production

Sixteen meat sheep farms (nine conventional and seven organic) in the centre of France were surveyed to evaluate their economic and production performances (previous interviews) and their strategies related to animal health with particular attention to internal parasites (present interview on health strategies). The organic farms were surveyed in mid-September 2006 and the conventional ones in October 2007. Each interview (1½ or 2 h) included a visit of the farm (with the collection of faeces for evaluation of internal parasites), followed by an open discussion on sheep production and health problems, and parasitic infections, in particular. The discussion was recorded and then transcribed into a word processor file and analysed. The farmers agreed on the fragile health of their animals (with special attention to internal parasites)and were confronted with the low value of each lamb or ewe, which does not allow for high health costs. Even under this limited economic situation, the farmers developed different health strategies. Conventional farmers rely on systematic treatments to prevent parasitic infection; they use low-cost effective synthetic drugs and accept lamb mortality rates ranging from five to eight percent. Their practices are homogeneous, which is possibly due to frequent exchanges with colleagues or veterinarians. The healthcare strategy of organic farmers may be divided into two distinct categories: autonomous (“self-made farmer”) and “creative”. The organic self-made farmers are experienced and aim at a sustainable flock (“cruiser flock”). The creative ones do not seem to easily handle the health strategy aspect and often spend more money on healthcare than their conventional or organic self-made colleagues. Health strategy is therefore not completely dependent on the type of production - conventional versus organic - but on the farmer’s conception of life and nature. The creative farmers believe that disease is a dysfunction that may be corrected with treatments (conventional or alternative ones), whereas the self-made farmers consider health as the result of a dynamic equilibrium between the many forces that interact within a flock. The latter is somewhat similar to the idea put forth in the book “The normal and the pathological” by Canguilhem

High density InAlAs/GaAlAs quantum dots for non-linear optics in microcavities

Structural and optical properties of InAlAs/GaAlAs quantum dots grown by molecular beam epitaxy are studied using transmission electron microscopy, temperature- and time resolvedphotoluminescence. The control of the recombination lifetime (50 ps – 1.25 ns), and of the dot density (5.10−8 – 2.1011 cm−3) strongly suggest that these material systems can find wide applications in opto-electronic devices as focusing non linear dispersive materials as well as fast saturable absorbers

NIKEL_AMC: Readout electronics for the NIKA2 experiment

The New Iram Kid Arrays-2 (NIKA2) instrument has recently been installed at the IRAM 30 m telescope. NIKA2 is a state-of-art instrument dedicated to mm-wave astronomy using microwave kinetic inductance detectors (KID) as sensors. The three arrays installed in the camera, two at 1.25 mm and one at 2.05 mm, feature a total of 3300 KIDs. To instrument these large array of detectors, a specifically designed electronics, composed of 20 readout boards and hosted in three microTCA crates, has been developed. The implemented solution and the achieved performances are presented in this paper. We find that multiplexing factors of up to 400 detectors per board can be achieved with homogeneous performance across boards in real observing conditions, and a factor of more than 3 decrease in volume with respect to previous generations.Comment: 21 pages; 16 figure

First-principles molecular-dynamics simulations of a hydrous silica melt: Structural properties and hydrogen diffusion mechanism

We use {\it ab initio} molecular dynamics simulations to study a sample of liquid silica containing 3.84 wt.% H$_2$O.We find that, for temperatures of 3000 K and 3500 K,water is almost exclusively dissolved as hydroxyl groups, the silica network is partially broken and static and dynamical properties of the silica network change considerably upon the addition of water.Water molecules or free O-H groups occur only at the highest temperature but are not stable and disintegrate rapidly.Structural properties of this system are compared to those of pure silica and sodium tetrasilicate melts at equivalent temperatures. These comparisons confirm the picture of a partially broken tetrahedral network in the hydrous liquid and suggest that the structure of the matrix is as much changed by the addition of water than it is by the addition of the same amount (in mole %) of sodium oxide. On larger length scales, correlations are qualitatively similar but seem to be more pronounced in the hydrous silica liquid. Finally, we study the diffusion mechanisms of the hydrogen atoms in the melt. It turns out that HOSi$_2$ triclusters and SiO dangling bonds play a decisive role as intermediate states for the hydrogen diffusion.Comment: 25 pages, 18 figures. submitte