2,525 research outputs found
Light scattering and phase behavior of Lysozyme-PEG mixtures
Measurements of liquid-liquid phase transition temperatures (cloud points) of
mixtures of a protein (lysozyme) and a polymer, poly(ethylene glycol) (PEG)
show that the addition of low molecular weight PEG stabilizes the mixture
whereas high molecular weight PEG was destabilizing. We demonstrate that this
behavior is inconsistent with an entropic depletion interaction between
lysozyme and PEG and suggest that an energetic attraction between lysozyme and
PEG is responsible. In order to independently characterize the lysozyme/PEG
interactions, light scattering experiments on the same mixtures were performed
to measure second and third virial coefficients. These measurements indicate
that PEG induces repulsion between lysozyme molecules, contrary to the
depletion prediction. Furthermore, it is shown that third virial terms must be
included in the mixture's free energy in order to qualitatively capture our
cloud point and light scattering data. The light scattering results were
consistent with the cloud point measurements and indicate that attractions do
exist between lysozyme and PEG.Comment: 5 pages, 2 figures, 1 tabl
The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology
Coronavirus disease 2019 (COVID-19) is a new disease with different phases that can be catastrophic for subpopulations of patients with cardiovascular and pulmonary disease states at baseline. Appreciation for these different phases and treatment modalities, including manipulation of ventilatory settings and therapeutics, has made it a less lethal disease than when it emerged earlier this year. Different aspects of the disease are still largely unknown. However, laboratory investigation and clinical course of the COVID-19 show that this new disease is not a typical acute respiratory distress syndrome process, especially during the first phase. For this reason, the best strategy to be applied is to treat differently the single phases and to support the single functions of the failing organs as they appear
Optimal phase estimation in quantum networks
We address the problem of estimating the phase phi given N copies of the
phase rotation u(phi) within an array of quantum operations in finite
dimensions. We first consider the special case where the array consists of an
arbitrary input state followed by any arrangement of the N phase rotations, and
ending with a POVM. We optimise the POVM for a given input state and fixed
arrangement. Then we also optimise the input state for some specific cost
functions. In all cases, the optimal POVM is equivalent to a quantum Fourier
transform in an appropriate basis. Examples and applications are given.Comment: 9 pages, 2 figures; this is an extended version of
arXiv:quant-ph/0609160. v2: minor corrections in reference
String amplitudes in arbitrary dimensions
We calculate gravitational dressed tachyon correlators in non critcal
dimensions. The 2D gravity part of our theory is constrained to constant
curvature. Then scaling dimensions of gravitational dressed vertex operators
are equal to their bare conformal dimensions. Considering the model as d+2
dimensional critical string we calculate poles of generalized Shapiro-Virasoro
amplitudes.Comment: 14 page
Impact of COVID-19 pandemic on chronic pain management: Looking for the best way to deliver care
Although pain treatment has been described as a fundamental human right, the Coronavirus disease 2019 (COVID-19) pandemic forced healthcare systems worldwide to redistribute healthcare resources toward intensive care units and other COVID-19 dedicated sites. As most chronic pain services were subsequently deemed non-urgent, all outpatient and elective interventional procedures have been reduced or interrupted during the COVID-19 pandemic in order to reduce the risk of viral spread. The shutdown of pain services jointly to the home lockdown imposed by governments has affected chronic pain management worldwide with additional impact on patients' psychological health. Therefore, the aim of this review is to analyze the impact of COVID-19 pandemic on chronic pain treatment and to address what types of strategies can be implemented or supported in order to overcome imposed limitations in delivery of chronic pain patient care
Impact of an interatrial shunt device on survival and heart failure hospitalization in patients with preserved ejection fraction
Aims:
Impaired left ventricular diastolic function leading to elevated left atrial pressures, particularly during exertion, is a key driver of symptoms and outcomes in heart failure with preserved ejection fraction (HFpEF). Insertion of an interatrial shunt device (IASD) to reduce left atrial pressure in HFpEF has been shown to be associated with short‐term haemodynamic and symptomatic benefit. We aimed to investigate the potential effects of IASD placement on HFpEF survival and heart failure hospitalization (HFH).
Methods and results:
Heart failure with preserved ejection fraction patients participating in the Reduce Elevated Left Atrial Pressure in Patients with Heart Failure study (Corvia Medical) of an IASD were followed for a median duration of 739 days. The theoretical impact of IASD implantation on HFpEF mortality was investigated by comparing the observed survival of the study cohort with the survival predicted from baseline data using the Meta‐analysis Global Group in Chronic Heart Failure heart failure risk survival score. Baseline and post‐IASD implant parameters associated with HFH were also investigated. Based upon the individual baseline demographic and cardiovascular profile of the study cohort, the Meta‐analysis Global Group in Chronic Heart Failure score‐predicted mortality was 10.2/100 pt years. The observed mortality rate of the IASD‐treated cohort was 3.4/100 pt years, representing a 33% lower rate (P = 0.02). By Kaplan–Meier analysis, the observed survival in IASD patients was greater than predicted (P = 0.014). Baseline parameters were not predictive of future HFH events; however, poorer exercise tolerance and a higher workload‐corrected exercise pulmonary capillary wedge pressure at the 6 months post‐IASD study were associated with HFH.
Conclusions:
The current study suggests IASD implantation may be associated with a reduction in mortality in HFpEF. Large‐scale ongoing randomized studies are required to confirm the potential benefit of this therapy
Approximating Fractional Time Quantum Evolution
An algorithm is presented for approximating arbitrary powers of a black box
unitary operation, , where is a real number, and
is a black box implementing an unknown unitary. The complexity of
this algorithm is calculated in terms of the number of calls to the black box,
the errors in the approximation, and a certain `gap' parameter. For general
and large , one should apply a total of times followed by our procedure for approximating the fractional
power . An example is also given where for
large integers this method is more efficient than direct application of
copies of . Further applications and related algorithms are also
discussed.Comment: 13 pages, 2 figure
Including all voices in international data-sharing governance
Background
Governments, funding bodies, institutions, and publishers have developed a number of strategies to encourage researchers to facilitate access to datasets. The rationale behind this approach is that this will bring a number of benefits and enable advances in healthcare and medicine by allowing the maximum returns from the investment in research, as well as reducing waste and promoting transparency. As this approach gains momentum, these data-sharing practices have implications for many kinds of research as they become standard practice across the world.
Main text
The governance frameworks that have been developed to support biomedical research are not well equipped to deal with the complexities of international data sharing. This system is nationally based and is dependent upon expert committees for oversight and compliance, which has often led to piece-meal decisionmaking. This system tends to perpetuate inequalities by obscuring the contributions and the important role of different data providers along the data stream, whether they be low- or middle-income country researchers, patients, research participants, groups, or communities. As research and data-sharing activities are largely publicly funded, there is a strong moral argument for including the people who provide the data in decision-making and to develop governance systems for their continued participation.
Conclusions
We recommend that governance of science becomes more transparent, representative, and responsive to the voices of many constituencies by conducting public consultations about data-sharing addressing issues of access and use; including all data providers in decision-making about the use and sharing of data along the whole of the data stream; and using digital technologies to encourage accessibility, transparency, and accountability. We anticipate that this approach could enhance the legitimacy of the research process, generate insights that may otherwise be overlooked or ignored, and help to bring valuable perspectives into the decision-making around international data sharing.</p
Mass and Angular Momentum Transfer in the Massive Algol Binary RY Persei
We present an investigation of H-alpha emission line variations observed in
the massive Algol binary, RY Per. We give new radial velocity data for the
secondary based upon our optical spectra and for the primary based upon high
dispersion UV spectra. We present revised orbital elements and an estimate of
the primary's projected rotational velocity (which indicates that the primary
is rotating 7 times faster than synchronous). We use a Doppler tomography
algorithm to reconstruct the individual primary and secondary spectra in the
region of H-alpha, and we subtract the latter from each of our observations to
obtain profiles of the primary and its disk alone. Our H-alpha observations of
RY Per show that the mass gaining primary is surrounded by a persistent but
time variable accretion disk. The profile that is observed outside-of-eclipse
has weak, double-peaked emission flanking a deep central absorption, and we
find that these properties can be reproduced by a disk model that includes the
absorption of photospheric light by the band of the disk seen in projection
against the face of the star. We developed a new method to reconstruct the disk
surface density distribution from the ensemble of H-alpha profiles observed
around the orbit, and this method accounts for the effects of disk occultation
by the stellar components, the obscuration of the primary by the disk, and flux
contributions from optically thick disk elements. The resulting surface density
distribution is elongated along the axis joining the stars, in the same way as
seen in hydrodynamical simulations of gas flows that strike the mass gainer
near trailing edge of the star. This type of gas stream configuration is
optimal for the transfer of angular momentum, and we show that rapid rotation
is found in other Algols that have passed through a similar stage.Comment: 39 pages, 12 figures, ApJ in press, 2004 June 20 issu
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