480 research outputs found
Is There an Age Pattern in the Treatment of AMI? Evidence from Ontario
In this article we analyse the rates at which those admitted to hospital with acute myocardial infarction (AMI) receive aggressive treatment, assess how those rates have changed over time, and ask whether there is evidence of age discrepancies. Estimates made on the basis of data from an administrative database that includes discharges from all acute care hospitals in Ontario for selected years, from 1995 to 2005, indicate that there are strong and persistent age patterns in the application of medical technology. Results showed that to be true even after controlling for the higher rates of co-morbidities among older patients and variations across hospitals in practice patterns.treatment of AMI, age pattern
Is There an Age Pattern in the Treatment of AMI? Evidence from Ontario
In this article we analyse the rates at which those admitted to hospital with acute myocardial infarction (AMI) receive aggressive treatment, assess how those rates have changed over time, and ask whether there is evidence of age discrepancies. Estimates made on the basis of data from an administrative database that includes discharges from all acute care hospitals in Ontario for selected years, from 1995 to 2005, indicate that there are strong and persistent age patterns in the application of medical technology. Results showed that to be true even after controlling for the higher rates of co-morbidities among older patients and variations across hospitals in practice patterns.treatment of AMI, age pattern
Development of a front end ASIC for Dark Matter directional detection with MIMAC
A front end ASIC (BiCMOS-SiGe 0.35 \mum) has been developed within the
framework of the MIMAC detector project, which aims at directional detection of
non-baryonic Dark Matter. This search strategy requires 3D reconstruction of
low energy (a few keV) tracks with a gaseous \muTPC. The development of this
front end ASIC is a key point of the project, allowing the 3D track
reconstruction. Each ASIC monitors 16 strips of pixels with charge
preamplifiers and their time over threshold is provided in real time by current
discriminators via two serializing LVDS links working at 320 MHz. The charge is
summed over the 16 strips and provided via a shaper. These specifications have
been chosen in order to build an auto triggered electronics. An acquisition
board and the related software were developed in order to validate this
methodology on a prototype chamber. The prototype detector presents an anode
where 2 x 96 strips of pixels are monitored.Comment: 12 pages, 10 figure
Dark matter directional detection with MIMAC
MiMac is a project of micro-TPC matrix of gaseous (He3, CF4) chambers for
direct detection of non-baryonic dark matter. Measurement of both track and
ionization energy will allow the electron-recoil discrimination, while access
to the directionnality of the tracks will open a unique way to distinguish a
geniune WIMP signal from any background. First reconstructed tracks of 5.9 keV
electrons are presented as a proof of concept.Comment: 4 pages, proc. of the 44th Rencontres De Moriond: Electroweak
Interactions And Unified Theories, 7-14 Mar 2009, La Thuile, Ital
Evaluation of building envelope retrofit techniques for reducing energy needs for space cooling.
One of the fastest growing sources of new energy demand is space cooling. According to EU-studies a four-fold growth in air-conditioned space is likely to take place between 1990 and 2020. The energy savings achievable in the end-use space cooling depend on a number of variables related to the building envelope, the plants and to some extent the behaviour of occupants. They are hence complex to evaluate and consequently often underrepresented in energy efficiency programmes and National Plans.
This paper is based on some preliminary results of the IEE project KeepCool 2. It discusses in particular:
a methodology for bottom-up assessment of the energy savings related to "sustainable summer comfort" solutions; reference base case building typologies are analyzed in 5 European climates, and dynamic simulations are used to calculate the reductions in the energy need for cooling which can be achieved by specific retrofit actions (e.g. additions of effective solar protections, increased thermal insulation, night ventilation, increase of active mass by PCM, low solar absorbance surfaces,...); situations where mechanical cooling can be avoided are evaluated using the Adaptive Comfort model, according to the norm EN 15251.
case studies of buildings with good summer comfort and low energy consumption performances, according to the ten steps of the KC2 procedure.
the analysis of case studies of "comfort policies" adopted by public and private bodies to ensure summer comfort with low energy consumption (commitments to give priority to heat load reductions instead of introducing mechanical cooling, relaxed dress codes, low thermal insulation chairs, local air velocity increase)
MIMAC : A micro-tpc matrix for directional detection of dark matter
Directional detection of non-baryonic Dark Matter is a promising search
strategy for discriminating WIMP events from background. However, this strategy
requires both a precise measurement of the energy down to a few keV and 3D
reconstruction of tracks down to a few mm. To achieve this goal, the MIMAC
project has been developed. It is based on a gaseous micro-TPC matrix, filled
with CF4 and CHF3. The first results on low energy nuclear recoils (H, F)
obtained with a low mono-energetic neutron field are presented. The discovery
potential of this search strategy is discussed and illustrated by a realistic
case accessible to MIMAC.Comment: 6 pages, Proc. of the fifth international symposium on large TPCs for
low energy rare event detection, Paris, France, Dec. 2010. To appear in
Journal of Physic
Data acquisition electronics and reconstruction software for directional detection of Dark Matter with MIMAC
Directional detection of galactic Dark Matter requires 3D reconstruction of
low energy nuclear recoils tracks. A dedicated acquisition electronics with
auto triggering feature and a real time track reconstruction software have been
developed within the framework of the MIMAC project of detector. This
auto-triggered acquisition electronic uses embedded processing to reduce data
transfer to its useful part only, i.e. decoded coordinates of hit tracks and
corresponding energy measurements. An acquisition software with on-line
monitoring and 3D track reconstruction is also presented.Comment: 17 pages, 12 figure
Micromegas micro-TPC for direct Dark Matter search with MIMAC
The MIMAC project is a multi-chamber detector for Dark Matter search, aiming
at measuring both track and ionization with a matrix of micromegas micro-TPC
filled with He3 and CF4. Recent experimental results on the first measurements
of the Helium quenching factor at low energy (1 keV recoil) are presented,
together with the first simulation of the track reconstruction. Recontruction
of track of alpha from Radon impurities is shown as a first proof of concept.Comment: 5 pages, Proc. of the fourth international symposium on large TPCs
for low energy rare event detection, Paris, France, Dec. 2008. To appear in
Journal of Physic
Renal Cell Carcinoma with Angioleiomyoma-Like Stroma and Clear Cell Papillary Renal Cell Carcinoma: Exploring SDHB Protein Immunohistochemistry and the Relationship to Tuberous Sclerosis Complex
Renal cell carcinoma (RCC) with angioleiomyoma-like stroma appears to be molecularly distinct from clear cell RCC; however, its relationship to clear cell papillary RCC remains debated. Recent studies have found that similar tumors sometimes occur in patients with tuberous sclerosis complex (TSC), of which one study found unexpectedly negative succinate dehydrogenase (SDH) B immunostaining. We evaluated immunohistochemistry for SDHB in 12 apparently sporadic RCCs with angioleiomyoma-like stroma and correlated with clinical information for stigmata of TSC. Tumors were compared to a group of 16 clear cell papillary RCCs and 6 unclassified tumors with prominent stroma. With exception of 1 unclassified tumor, all exhibited at least focal cytoplasmic staining for SDHB protein, often requiring high magnification and better appreciated with increased antibody concentration. Detailed history information was available for 9/12 patients with smooth muscle-rich tumors, revealing no stigmata of undiagnosed TSC. Electron microscopy performed on 1 of these tumors revealed mitochondria to be very sparse, potentially accounting for the weak immunohistochemical labeling for SDHB protein. Weak SDHB immunostaining may represent another shared feature of RCC with angioleiomyoma-like stroma and clear cell papillary RCC, likely due to sparse mitochondria, strengthening the possible relationship of these entities. Although smooth muscle-rich tumors have been recently reported in patients with TSC, absence of staining in tumors with this pattern may not be specific for TSC. In tumors with pale or clear cytoplasm, immunohistochemical staining for SDHB should be interpreted with caution as evidence of abnormality in the SDH pathway
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