23 research outputs found
Toxic Effects of Glyphosate on Environment and Human Health
Globally, massive amounts of pesticides are manufactured and used both in agriculture and households to get rid of various pests, some of which reach soils and aquatic systems through various pathways. Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely used pesticides worldwide. Glyphosate is a non-selective herbicide that is effective against all types of weeds and has been used for many years. Their uses have increased exponentially since their introduction into the market. Residue levels in food or water, as well as human exposures, are escalating including in the environmental segments. It can, therefore, be found as a contaminant in water, and procedures are required for its removal. This work investigates the toxic effects associated with the use of Glyphosate on environmental and human health. © 2020 Author(s).Dr. BGR is highly thankful to UGC for the award of Post Doctoral Fellowship, File No. F./PDFSS-2014-15-SCAND-7541
Interplay of magnetic order and Jahn-Teller distortion in a model with strongly correlated electron system
The Hubbard model has been employed successfully to understand many aspects
of correlation driven physical properties, in particular, the magnetic order in
itenerant electron systems. In some systems such as Heusler alloys, manganites
etc., it is known that, in addition to magnetic order, distortion induced by
Jahn-Teller(J-T) effect also exists. In this paper, based on two-fold
degenerate Hubbard model, the influence of magnetic order on J-T distortion is
investigated. The electron correlation is treated using a spectral density
approach and J-T interaction is added to the model. We find that magnetic order
and structural distortion coexist at low temperature for a certain range of
electron correlation strength , J-T coupling strength and band
occupation . At T=0, for a given and , magnetic order is present but
distortion appears only for a larger than a critical value. We also studied
the temperature dependence of lattice strain and magnetization choosing a
close to the critical value.Comment: 12 pages, 5 Figures. Physica- B 405 1701-1705 (2010
Phytochemical investigation of the whole plant of Astragalus leucocephalus
1329-1332Three new lanostene
type triterpenoids, astragalone, astragalene, sieversigenin and a known
triterpenoid, cyclosieversigenin and a flavone kaempferol, have been isolated
from the methanol extract of whole plant. Their structures have been elucidated
mainly by spectroscopic method
Prevalence of HBC and HCV dual infections in patients on haemodialysis
Hepatitis viral infections are important causes of morbidity and
mortality in haemodialysis patients. One hundred and thirty four
patients attending haemodialysis unit were screened for the presence of
HBV and HCV infections. Eight (5.9%) patients were HCV positive while
two (1.4%) patients had HBV infection. A dual infection with both the
viruses was observed in five patients (3.7%)
The role of the c-Met pathway in lung cancer and the potential for targeted therapy
Hepatocyte growth factor receptor (HGFR), the product of the MET gene, plays an important role in normal cellular function and oncogenesis. In cancer, HGFR has been implicated in cellular proliferation, cell survival, invasion, cell motility, metastasis and angiogenesis. Activation of HGFR can occur through binding to its ligand, hepatocyte growth factor (HGF), overexpression/amplification, mutation, and/or decreased degradation. Amplification of HGFR can occur de novo or in resistance to therapy. Mutations of HGFR have been described in the tyrosine kinase domain, juxtamembrane domain, or semaphorin domain in a number of tumors. These mutations appear to have gain of function, and also reflect differential sensitivity to therapeutic inhibition. There have been various drugs developed to target HGFR, including antibodies to HGFR/HGF, small-molecule inhibitors against the tyrosine kinase domain of HGFR and downstream targets. Different HGFR inhibitors are currently in clinical trials in lung cancer and a number of solid tumors. Several phase I trials have already been completed, and two specific trials have been reported combining HGFR with epidermal growth factor receptor (EGFR) inhibition in non-small cell lung cancer. In particular, trials involving MetMAb and ARQ197 (tivantinib) have gained interest. Ultimately, as individualized therapies become a reality for cancers, HGFR will be an important molecular target