The Profile of Distal Radius Fracture Colles\u27 Type at Dr. Soetomo Hospital in 2013

The fracture cases become increase because the rapid development of transportation and human mobility today is not offset by good vigilance in conducting the activity. One of the most common location is in the hand and involves distal radius part, named Colles\u27 fracture. Colles\u27 fracture is the most common wrist fracture (almost 80% of the forearm fractures and the incidence rise in elderly people especially woman. The adequate distribution data of Colles\u27 Fracture is not available yet. If this situation keeps going, it will have impacts on the lack of preventive measures and recovery methods. The study was design as descriptive and used secondary data from medical records in Orthopedics and Traumatology Department of Dr. Soetomo Hospital Surabaya. Total 37 patients that included in inclusion criteria. Distal radius fracture Colles\u27 type was common in woman. The most common age was 45-64 years old. Most common causes of fracture was traffic accidents. Left forearm become major affected side. The incidence dominantly occurred at the street. The incidence often occurred at 12.00-18.00. The onset of admission from the incidence place to hospital was less than 8 hours

Hubungan Antara Beban Kerja Dengan Gangguan Pola Tidur Pada Perawat Di Instalasi Gawat Darurat Non Trauma Rsup Prof Dr. R. D. Kandou Manado

: Sleeping is the basic need for humanbeing without the enough amount of both rest and sleeping, the ability in contrentration, making decision, and participating in daily activites will decrease. The aim of this research: is to find out the relation of work responsibility with the discruption of sleeping habit to the nurses in Non Trauma Emergency Care Unit of Prof. Dr. R. D. Kandou General Hospital Manado. The Method of the research: was in characteristic of analytical observational with cross sectional approach. The sample that taken was total sampling with 32 respondents. The instrument that used in this research was questioner. The result of this research was using chi square statistically test analysis with its meaning level was α = 0.05 or 95%. The result of statistic test be found the value p = 0.006 < α = 0.05. Conclusion: there is relationship between nurses work responsibility with the discruption of the sleeping habit to the nurse in Non Trauma Emergency Care Unit of Prof. Dr. R. D. Kandou General Hospital Manado. Suggestions : The nurses suggested to arrange their time very well such as how to use their time after work, and get rest before continue their next activities and also keep their own stamina before doing their official duty so that they will be able to do their job effectively

Bilateral variations of brachial plexus involving the median nerve and lateral cord: An anatomical case study with clinical implications

During the routine dissection of upper limbs of a Caucasian male cadaver, variations were observed in the brachial plexus. In the right extremity, the lateral cord was piercing the coracobrachialis muscle. The musculocutaneous nerve and lateral root of the median nerve were observed to be branching inferior to the lower attachment of coracobrachialis muscle. The left extremity exhibited the passage of the median nerve through the flat tendon of the coracobrachialis muscle near its distal insertion into the medial surface of the body of humerus. A variation in the course and branching of the nerve might lead to variant or dual innervation of a muscle and, if inappropriately compressed, could result in a distal neuropathy. Identification of these variants of brachial plexus plays an especially important role in both clinical diagnosis and surgical practice.

The impact of mass-transfer physics on the observable properties of field binary black hole populations

We study the impact of mass-transfer physics on the observable properties of binary black hole populations formed through isolated binary evolution. We investigate the impact of mass-accretion efficiency onto compact objects and common-envelope efficiency on the observed distributions of $\chi_{eff}$, $M_{chirp}$ and $q$. We find that low common envelope efficiency translates to tighter orbits post common envelope and therefore more tidally spun up second-born black holes. However, these systems have short merger timescales and are only marginally detectable by current gravitational-waves detectors as they form and merge at high redshifts ($z\sim 2$), outside current detector horizons. Assuming Eddington-limited accretion efficiency and that the first-born black hole is formed with a negligible spin, we find that all non-zero $\chi_{eff}$ systems in the detectable population can come only from the common envelope channel as the stable mass-transfer channel cannot shrink the orbits enough for efficient tidal spin-up to take place. We find the local rate density ($z\simeq 0.01$) for the common envelope channel is in the range $\sim 17-113~Gpc^{-3}yr^{-1}$ considering a range of $\alpha_{CE} \in [0.2,5.0]$ while for the stable mass transfer channel the rate density is $\sim 25~Gpc^{-3}yr^{-1}$. The latter drops by two orders of magnitude if the mass accretion onto the black hole is not Eddington limited because conservative mass transfer does not shrink the orbit as efficiently as non-conservative mass transfer does. Finally, using GWTC-2 events, we constrain the lower bound of branching fraction from other formation channels in the detected population to be $\sim 0.2$. Assuming all remaining events to be formed through either stable mass transfer or common envelope channels, we find moderate to strong evidence in favour of models with inefficient common envelopes.Comment: 26 pages, 13 figures, accepted for publication in A&

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC expansion in response to infection. We find that infection by Gram-negative bacteria drives an increase in mitochondrial mass in mammalian HSCs, which results in a metabolic transition from glycolysis toward oxidative phosphorylation. The initial increase in mitochondrial mass occurs as a result of mitochondrial transfer from the bone marrow stromal cells (BMSCs) to HSCs through a reactive oxygen species (ROS)-dependent mechanism. Mechanistically, ROS-induced oxidative stress regulates the opening of connexin channels in a system mediated by phosphoinositide 3-kinase (PI3K) activation, which allows the mitochondria to transfer from BMSCs into HSCs. Moreover, mitochondria transfer from BMSCs into HSCs, in the response to bacterial infection, occurs before the HSCs activate their own transcriptional program for mitochondrial biogenesis. Our discovery demonstrates that mitochondrial transfer from the bone marrow microenvironment to HSCs is an early physiologic event in the mammalian response to acute bacterial infection and results in bioenergetic changes which underpin emergency granulopoiesis

Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies

Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed. Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein homodimers. However, recombinantly expressed soluble E proteins are monomers under vaccination conditions and do not present these quaternary epitopes, partly explaining their limited success as vaccine antigens. Using molecular modeling, we found DENV2 E protein mutations that induce dimerization at low concentrations (\u3c100 pM) and enhance production yield by more than 50-fold. Cross-dimer epitope antibodies bind to the stabilized dimers, and a crystal structure resembles the wild-type (WT) E protein bound to a dimer epitope antibody. Mice immunized with the stabilized dimers developed antibodies that bind to E dimers and not monomers and elicited higher levels of DENV2-neutralizing antibodies compared to mice immunized with WT E antigen. Our findings demonstrate the feasibility of using structure-based design to produce subunit vaccines for dengue and other flaviviruses