Algebraic coarsening in voter models with intermediate states

The introduction of intermediate states in the dynamics of the voter model modifies the ordering process and restores an effective surface tension. The logarithmic coarsening of the conventional voter model in two dimensions is eliminated in favour of an algebraic decay of the density of interfaces with time, compatible with Model A dynamics at low temperatures. This phenomenon is addressed by deriving Langevin equations for the dynamics of appropriately defined continuous fields. These equations are analyzed using field theoretical arguments and by means of a recently proposed numerical technique for the integration of stochastic equations with multiplicative noise. We find good agreement with lattice simulations of the microscopic model.Comment: 11 pages, 5 figures; minor typos correcte

Seismic Design and Preliminary Analyses of a Prefabricated Hybrid Steel-Concrete Wall

Steel frames with reinforced concrete infill walls (SRCWs) are an interesting structural solution for applications in seismic areas if designed to exploit the stiffness of reinforced concrete (RC) and the ductility and dissipative capacity of steel. Three horizontal resisting mechanisms can be identified in SRCW: 1) contribution of the steel frame; 2) direct interactions between the steel frame and the compression strut in the RC infill walls; 3) interactions between steel frame and the RC infill wall through friction and shear connectors. While Eurocode 8 considers SRCWs to behave essentially as RC walls, numerical analyses demonstrated that this assumption may be far from reality. Innovative solutions for SRCW and relevant design approaches were eventually proposed in order to achieve a structural system able to fully exploit the advantages of the steel and RC components. In this context, the present study investigates a type of innovative modular SRCW through numerical simulations allowing a better understanding of its structural behaviour

Monitoring fetal well-being in labor in late fetal growth restriction

Late-onset fetal growth restriction (FGr) accounts for approximately 70-80% of all cases of FGr secondary to uteroplacental insufficiency. It is associated with an increased incidence of adverse antepartum and perinatal events, which in most instances result from hypoxic insults either present at the onset of labor or supervening during labor as a result of uterine contractions. labor represents a stressful event for the fetoplacental unit being uterine contractions associated with an up-to 60% reduction of the uteroplacental perfusion. intrapartum fetal heart rate monitoring by means of cardiotocography (CTG) currently represents the mainstay for the identification of fetal hypoxia during labor and is recommended for the fetal surveillance during labor in the case of FGr or other conditions associated with an increased risk of intrapartum hypoxia. in this review we discuss the potential implications of an impaired placental function on the intrapartum adaptation to the hypoxic stress and the role of the ctG and alternative techniques for the intrapartum monitoring of the fetal wellbeing in the context of FGR secondary to uteroplacental insufficiency

A Resilience and Robustness Oriented Design of Base-Isolated Structures: The New Camerino University Research Center

This paper analyses the new Research Centre designed for the University of Camerino and entirely financed by the national Civil Protection Department (DPC), following the seismic events in Central Italy in 2016. The building has been designed to guarantee speed of execution as well as a high level of safety, especially regarding seismic actions. The structural solution was to create an isolated system with a steel braced super-structure with pinned joints and r.c. sub-structures able to adapt to the complex morphology of the area. As described in the first part of the paper, design choices have been made to achieve a high level of resilience and robustness, i.e., to limit damage to structural and non-structural components and equipment under moderate and design seismic actions and to avoid disproportionate consequences in the event of extreme actions, larger than the design ones. In the second part of the paper, specific risk analyses have been carried out to evaluate the real performance of the building under increasing intensity levels, with reference to both serviceability and ultimate conditions. To this purpose a site-specific hazard study was first conducted, then non-linear analyses were performed using a hazard-consistent set of records with return periods ranging from TR = 60 years to TR = 10000 years. The main demand parameters of both the isolation system and the super-structure were recorded and capacity values corresponding to different ultimate and damage limit conditions were defined. The results obtained in terms of demand hazard curves show that the building performances in terms of robustness and resilience are very high, confirming the efficacy of the strategies adopted in the design

Condition numbers and scale free graphs

In this work we study the condition number of the least square matrix corresponding to scale free networks. We compute a theoretical lower bound of the condition number which proves that they are ill conditioned. Also, we analyze several matrices from networks generated with the linear preferential attachment model showing that it is very difficult to compute the power law exponent by the least square method due to the severe lost of accuracy expected from the corresponding condition numbers.Comment: Submitted to EP

Prenatal visualisation of the torcular herophili by means of a Doppler technology highly sensitive for low-velocity flow in the expert assessment of the posterior fossa: a prospective study

Objective: To evaluate the usefulness of a Doppler technology highly sensitive for low-velocity flow in the antenatal imaging of the torcular herophili (TH) in the second trimester of pregnancy. Design: Prospective study. Setting: Referral Fetal Medicine Unit. Population: Non-consecutive series of singleton pregnancies submitted to antenatal neurosonogram between 20 and 28 weeks of gestation. Methods: A midsagittal section of the fetal brain was obtained by insonating through the anterior fontanelle, then the MV-Flow™ and LumiFlow™ presets were selected to visualise the TH as the posterior confluence of the superior sagittal sinus and the straight sinus. Main outcome measures: Evaluation of the anatomic relationship of the TH with the ‘transpalatal line’ joining the upper bony palate to the fetal skull. Results: A total of 99 pregnant women were recruited, including one fetus with open spina bifida, one with Dandy–Walker malformation (DWM) and two with Blake's pouch cysts. In normal fetuses, the TH appeared to lie on or just below the ‘transpalatal line’. In the cases of Blake's pouch cyst, the position of the TH appeared normal if compared with controls, whereas in DWM a supra-elevated position of the TH in respect of the transpalatal line was demonstrated. Finally, in the fetus with Chiari II malformation the TH was identified below the ‘transpalatal plane’. Conclusions: Prenatal ultrasound visualisation of the TH by means of newly developed Doppler technologies characterised by high sensitivity for low-velocity flow is feasible and allows the indirect evaluation of the insertion of cerebellar tentorium in the second trimester. Tweetable abstract: Prenatal imaging of the torcular herophili using a Doppler technology highly sensitive for low-velocity flow

Pathways of L-glutamic acid transport in cultured human fibroblasts.

The transport of L-glutamic acid has been studied in skin-derived diploid human fibroblasts. Competition analysis in the presence and absence of Na+ and mathematical discrimination by nonlinear regression indicated that L-glutamic acid enters the cell by at least three transport systems: 1) a high affinity Na+-dependent system which has been found to be identical to the previously described system for anionic amino acids (Gazzola, G. C., Dall'Asta, V., Bussolati, O., Makowske, M., and Christensen, H. N. (1981) J. Biol. Chem. 256, 6054-6059) and which is provisionally designated as System X-AG; this route was shared by L-aspartic acid; 2) a low affinity Na+-dependent system resembling the ASC System for neutral amino acids (Franchi-Gazzola, R., Gazzola, G. C., Dall'Asta, V., and Guidotti, G. G. (1982) J. Biol. Chem. 257, 9582-9587); its reactivity toward L-glutamic acid was strongly inhibited by L-serine, but not by 2-(methyl-amino)isobutyric acid; and 3) a Na+-independent system similar to System XC- described in fetal human lung fibroblasts (Bannai, S., and Kitamura, E. (1980) J. Biol. Chem. 255, 2372-2376). The XC- system served for L-glutamic acid and L-cystine, the latter amino acid behaving as a potent inhibitor of L-glutamic acid uptake. Amino acid starvation did not change the uptake of L-glutamic acid by the two Na+-dependent systems, but enhanced the activity of System XC- by increasing its Vmax. L-Glutamic acid transport was also affected by the density of the culture. An increased cell density lowered the uptake of the amino acid by Systems ASC and XC- and promoted the uptake by System X-AG. All these variations were dependent upon changes in Vmax

The Segmented Zambezi Sedimentary System from Source to Sink: 1. Sand Petrology and Heavy Minerals

The Zambezi River rises at the center of southern Africa, flows across the low-relief Kalahari Plateau, meets Karoo basalt, plunges into Victoria Falls, follows along Karoo rifts, and pierces through Precambrian basement to eventually deliver its load onto the Mozambican passive margin. Reflecting its polyphase evolution, the river is subdivided into segments with different geological and geomorphological character, a subdivision finally fixed by man’s construction of large reservoirs and faithfully testified by sharp changes in sediment composition. Pure quartzose sand recycled from Kalahari desert dunes in the uppermost tract is next progressively enriched in basaltic rock fragments and clinopyroxene. Sediment load is renewed first downstream of Lake Kariba and next downstream of Lake Cahora Bassa, documenting a stepwise decrease in quartz and durable heavy minerals. Composition becomes quartzo-feldspathic in the lower tract, where most sediment is supplied by high-grade basements rejuvenated by the southward propagation of the East African rift. Feldspar abundance in Lower Zambezi sand has no equivalent among big rivers on Earth and far exceeds that in sediments of the northern delta, shelf, and slope, revealing that provenance signals from the upper reaches have ceased to be transmitted across the routing system after closure of the big dams. This high-resolution petrologic study of Zambezi sand allows us to critically reconsider several dogmas, such as the supposed increase of mineralogical “maturity” during long-distance fluvial transport, and forges a key to unlock the rich information stored in sedimentary archives, with the ultimate goal to accurately reconstruct the evolution of this mighty river flowing across changing African landscapes since the late Mesozoic

Desmopressin Stimulates Nitric Oxide Production in Human Lung Microvascular Endothelial Cells

Desmopressin (dDAVP) is the best characterized analogue of vasopressin, the endocrine regulator of water balance endowed with potent vasoconstrictive effects. Despite the use of dDAVP in clinical practice, ranging from the treatment of nephrogenic diabetes insipidus to bleeding disorders, much remains to be understood about the impact of the drug on endothelial phenotype. The aim of this study was, thus, to evaluate the effects of desmopressin on the viability and function of human pulmonary microvascular endothelial cells (HLMVECs). The results obtained demonstrate that the vasopressor had no cytotoxic effect on the endothelium; similarly, no sign of endothelial activation was induced by dDAVP, indicated by the lack of effect on the expression of inflammatory cytokines and adhesion molecules. Conversely, the drug significantly stimulated the production of nitric oxide (NO) and the expression of the inducible isoform of nitric oxide synthase, NOS2/iNOS. Since the intracellular level of cAMP also increased, we can hypothesize that NO release is consequent to the activation of the vasopressin receptor 2 (V2R)/guanylate cyclase (Gs)/cAMP axis. Given the multifaceted role of NOS2-deriving NO for many physio-pathological conditions, the meanings of these findings in HLMVECs appears intriguing and deserves to be further addressed