Adaptation to Climate Change in the Transport Sector

In this study, we review the literature on climate change adaptation measures in the transport sector. Many of the measures proposed are rather conceptual and far from concrete, probably due to the fact that climate change effects on transport are either unknown or highly uncertain. Given the limited information on the potential magnitude of climate damages and the various uncertainties involved, postponement of adaptation investments may well be the most sensible strategy at the moment, especially when investments are substantial and irreversible. Furthermore, monitoring of relevant climatic changes and ongoing research into climate change effects are important elements of a pro-active adaptation strategy. Irreversible decisions, such as the ones on spatial organization, likely require a more active strategy, e.g. in the form of making spatial reservations. We further discuss the interdependency between optimal mitigation and adaptation, an issue that is often overlooked in the literature. Finally, most operators and governmental bodies are not used to dealing with risk and uncertainty, and generally base their decisions on single risk values only, likely leading to under- or overinvestment. We discuss several relevant topics in this area and highlight methods that can be used to better deal with these issues. © 2012 Copyright Taylor and Francis Group, LLC

NUMERICAL SIMULATION OF CONFINED NANO-IMPINGING JET IN MICROSCALE COOLING APPLICATION USING DSMC METHOD

ABSTRACT In this study, we simulate rarefied gas flow through a confined nano-impinging jet using direct simulation Monte Carlo (DSMC) method. The effects of geometrical parameters, pressure ratio, and wall conditions on the heat transfer from a hot surface are examined. Hot surface modeled via diffusive constant wall temperature. Various inlet/confining surface conditions such as specular, adiabatic, and constant temperature are implemented and the effects of them on the wall heat flux rates are studied. The results show that Knudsen number, velocity slip, and temperature jump are main reasons which specify magnitudes of wall heat flux rates. Among all geometrical parameters, H/W ratio has the greatest effect on heat transfer, where H is jet distance from the hot surface and W is the jet width. For different values of pressure ratio, the biggest quantity of wall heat flux rate relates to the lowest velocity slip case. Also for inlet/confining walls with constant temperature condition equal to coolant flow temperature, heat transfer from the hot surface was the maximum

Using learning environments as a metaphor for educational change

Purpose – The purpose of this paper is to show that the online learning environment can be seen as the means by which higher education can explore the challenges and opportunities raised by online and digital society. Design/methodology/approach – The paper argues that the online learning environment can be seen as a metaphor for how universities respond to the requirements and challenges of the digital age. Current learning management systems (LMSs) are examined, and compared with the values found in web 2.0 and social media. Current thinking on pedagogy for online learning is then examined. The SocialLearn project at the Open University in the UK is then explained, which seeks to create a disaggregated, decentralised, social system for learners. Findings – The conclusion from the analysis is that there is a conflict between the centralised learning management system (LMS) and the requirements of online pedagogy. The traditional LMS can be seen as embodying the wrong metaphor, that of the traditional classroom. The paper concludes by arguing that such learning environments will be more useful to higher education in coming to understand its response to many of the changes being seen in society, which are facilitated by the new technologies. Originality/value – The paper provides a framework for considering LMSs and their relation to universities and pedagogy, and an argument for the promotion of more decentralised systems

Spatial variability of soil salinity in Bohai Sea coastal wetlands, China: Partition into four management zones

Soil salinization constitutes an environmental hazard worldwide. The Bohai Sea coastal wetland area is experiencing dramatic soil salinization, which is affecting its economic development. This study focused on the spatial variation and distribution characteristics of soil salinity in this area using geostatistical analysis combined with the kriging interpolation method, based on a large-scale field investigation and layered soil sampling (0-30, 30-60 and 60-100cm). The results revealed that soil salinity in these layers demonstrated strong variability, obvious spatial structure characteristics and strong spatial autocorrelation. Soil salinity displayed a significant zonal distribution, gradually decreasing with increasing distance from the coastline. Apart from the northern part of the study area, which appeared to be not affected by soil salinization, there were varying degrees of soil salinization in nearly 70% of the total area. With increasing soil depth, the areas of non-salinized and mild salinized soil gradually decreased, while those of moderate salinized and strong salinized soils increased. The area of saline soil first decreased and then increased. The study area could be divided into four management zones according to soil salinities in the top 1-m soil body, and utilization measures, adapted to local conditions, were proposed for each zone. The results of our study present an important theoretical basis for the improvement of saline soils, for wetland re-vegetation and for the sustainable utilization of soil resources in the Bohai Sea coastal wetland.Soil salinization constitutes an environmental hazard worldwide. The Bohai Sea coastal wetland area is experiencing dramatic soil salinization, which is affecting its economic development. This study focused on the spatial variation and distribution characteristics of soil salinity in this area using geostatistical analysis combined with the kriging interpolation method, based on a large-scale field investigation and layered soil sampling (0-30, 30-60 and 60-100cm). The results revealed that soil salinity in these layers demonstrated strong variability, obvious spatial structure characteristics and strong spatial autocorrelation. Soil salinity displayed a significant zonal distribution, gradually decreasing with increasing distance from the coastline. Apart from the northern part of the study area, which appeared to be not affected by soil salinization, there were varying degrees of soil salinization in nearly 70% of the total area. With increasing soil depth, the areas of non-salinized and mild salinized soil gradually decreased, while those of moderate salinized and strong salinized soils increased. The area of saline soil first decreased and then increased. The study area could be divided into four management zones according to soil salinities in the top 1-m soil body, and utilization measures, adapted to local conditions, were proposed for each zone. The results of our study present an important theoretical basis for the improvement of saline soils, for wetland re-vegetation and for the sustainable utilization of soil resources in the Bohai Sea coastal wetland

Метафизическое значение категорий предмета и непредмета в логике, поясняемое примерами решения антиномии Рассела в теории типов и аксиоматической системе NBG

Метафизическое значение категорий предмета и непредмета в логике, поясняемое примерами решения антиномии Рассела в теории типов и аксиоматической системе NB

Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients.

Gastro-Oesophageal Reflux (GOR) is a key problem in Cystic Fibrosis (CF), but the relationship between lung and gastric microbiomes is not well understood. We hypothesised that CF gastric and lung microbiomes are related. Gastric and sputum cultures were obtained from fifteen CF patients receiving percutaneous endoscopic gastrostomy feeding. Non-CF gastric juice data was obtained through endoscopy from 14 patients without lung disease. Bacterial and fungal isolates were identified by culture. Molecular bacterial profiling used next generation sequencing (NGS) of the 16S rRNA gene. Cultures grew bacteria and/or fungi in all CF gastric juice and sputa and in 9/14 non-CF gastric juices. Pseudomonas aeruginosa(Pa) was present in CF sputum in 11 patients, 4 had identical Pa strains in the stomach. NGS data from non-CF gastric juice samples were significantly more diverse compared to CF samples. NGS showed CF gastric juice had markedly lower abundance of normal gut bacteria; Bacteroides and Faecalibacterium, but increased Pseudomonas compared with non-CF. Multivariate partial least squares discriminant analysis demonstrated similar bacterial profiles of CF sputum and gastric juice samples, which were distinct from non-CF gastric juice. We provide novel evidence suggesting the existence of an aerodigestive microbiome in CF, which may have clinical relevance

Suppression of Adenosine-Activated Chloride Transport by Ethanol in Airway Epithelia

Alcohol abuse is associated with increased lung infections. Molecular understanding of the underlying mechanisms is not complete. Airway epithelial ion transport regulates the homeostasis of airway surface liquid, essential for airway mucosal immunity and lung host defense. Here, air-liquid interface cultures of Calu-3 epithelial cells were basolaterally exposed to physiologically relevant concentrations of ethanol (0, 25, 50 and 100 mM) for 24 hours and adenosine-stimulated ion transport was measured by Ussing chamber. The ethanol exposure reduced the epithelial short-circuit currents (ISC) in a dose-dependent manner. The ion currents activated by adenosine were chloride conductance mediated by cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel. Alloxazine, a specific inhibitor for A2B adenosine receptor (A2BAR), largely abolished the adenosine-stimulated chloride transport, suggesting that A2BAR is a major receptor responsible for regulating the chloride transport of the cells. Ethanol significantly reduced intracellular cAMP production upon adenosine stimulation. Moreover, ethanol-suppression of the chloride secretion was able to be restored by cAMP analogs or by inhibitors to block cAMP degradation. These results imply that ethanol exposure dysregulates CFTR-mediated chloride transport in airways by suppression of adenosine-A2BAR-cAMP signaling pathway, which might contribute to alcohol-associated lung infections

An investigation of the apparent breast cancer epidemic in France: screening and incidence trends in birth cohorts

<p>Abstract</p> <p>Background</p> <p>Official descriptive data from France showed a strong increase in breast-cancer incidence between 1980 to 2005 without a corresponding change in breast-cancer mortality. This study quantifies the part of incidence increase due to secular changes in risk factor exposure and in overdiagnosis due to organised or opportunistic screening. Overdiagnosis was defined as non progressive tumours diagnosed as cancer at histology or progressive cancer that would remain asymptomatic until time of death for another cause.</p> <p>Methods</p> <p>Comparison between age-matched cohorts from 1980 to 2005. All women residing in France and born 1911-1915, 1926-1930 and 1941-1945 are included. Sources are official data sets and published French reports on screening by mammography, age and time specific breast-cancer incidence and mortality, hormone replacement therapy, alcohol and obesity. Outcome measures include breast-cancer incidence differences adjusted for changes in risk factor distributions between pairs of age-matched cohorts who had experienced different levels of screening intensity.</p> <p>Results</p> <p>There was an 8-fold increase in the number of mammography machines operating in France between 1980 and 2000. Opportunistic and organised screening increased over time. In comparison to age-matched cohorts born 15 years earlier, recent cohorts had adjusted incidence proportion over 11 years that were 76% higher [95% confidence limits (CL) 67%, 85%] for women aged 50 to 64 years and 23% higher [95% CL 15%, 31%] for women aged 65 to 79 years. Given that mortality did not change correspondingly, this increase in adjusted 11 year incidence proportion was considered as an estimate of overdiagnosis.</p> <p>Conclusions</p> <p>Breast cancer may be overdiagnosed because screening increases diagnosis of slowly progressing non-life threatening cancer and increases misdiagnosis among women without progressive cancer. We suggest that these effects could largely explain the reported "epidemic" of breast cancer in France. Better predictive classification of tumours is needed in order to avoid unnecessary cancer diagnoses and subsequent procedures.</p