COMBINED USE OF SPACE-BORNE OBSERVATIONS OF NO2 AND REGIONAL CTM MODEL FOR AIR QUALITY MONITORING IN NORTHERN ITALY

The use of space-borne measurements of trace gas constituents for air quality monitoring is considerably increased during the past decade. This is due mainly to the new generation sensors able to observe large areas with good temporal resolution and due to new assimilation techniques that allow a synergetic use of information from satellite and from Chemical Transport Models (CTM). In fact the in situ sampling method used by the local environmental agencies for air quality monitoring is becoming too expensive to be further continued without a sensible reduction in the number of observing stations. In this paper we present the work that has been performed so far within the QUITSAT project funded by the Italian Space Agency. SCIAMACHY (Uv-Vis spectrometer on board ESA-ENVISAT platform from 2002) observations of earth radiance are used to retrieve NO2 tropospheric column by DOAS spectrometric technique and radiative transfer modelling for AMF computation. Such kind of product has been widely used to estimate emissions, to monitor pollution hot spot as well as cross country and intercontinental transport. Within this work we have merged the column measurements of nitrogen dioxide with the simulations of the Transport Chemical Aerosol Model (TCAM) to improve the model output at the ground level. The method used is a weighted rescaling of the model column in the troposphere according to the SCIAMACHY observations where the weights are the measurement errors and the model column variances within the satellite ground-pixel, respectively. The employed data are related to the Northern Italy area. The obtained ground concentrations of NO2 have been compared with in-situ observations performed by the regional environmental agencies. Results show good agreement mainly where well horizontal mixing is present. The ground concentration from SCIAMACHY-TCAM gives an average NO2 amount within the satellite ground-pixel of 30x60 km2 that is important information for air quality assessment on a regional and/or national scale not easy to obtain only with ground-based observations. Our conclusions thus stress also the actual potential role of satellite observations combined with regional CTM models in the context of air quality monitoring, mainly in rural area, where the ground-based observations are missing

Modern imaging methods and preoperative management of pheochromocytoma: review of the literature and case report.

OBJECTIVES: To discuss the modern imaging techniques and preoperative management of pheochromocytoma and to report on one additional case. METHODS: A 66-year-old male with an incidentally discovered left adrenal mass is described. The adrenal medulla strongly accumulate 131 I-metaiodobenzylguanidine (MIBG). The patient underwent left adrenalectomy after preoperative therapy with alpha and beta-blockers. The recent literature on pheochromocytoma modern imaging techniques and preoperative management is reviewed. RESULTS: MIBG scintigraphy diagnosed a benign functioning adrenal pheochromocytoma, allowing preoperative medical management. Postoperative workup was unremarkable. Diagnosis of pheochromocytoma was confirmed by immunohistopathology. At 18 months follow-up, the patient is alive and disease-free. CONCLUSIONS: Incidentally discovered adrenal masses have to be investigated to detect malignancy and subtle hormonal overproduction. MIBG scintigraphy has a high specificity (100%) in detecting pheochromocytoma, metastasis, surgical residual tumor, local relapse and other adrenal crest tumors. Positive results of octreotide scintigraphy in detecting malignant pheochromocytoma have been reported. Currently, pheochromocytoma removal is a safe operation with mortality rates ranging from 0 to less than 3%. Preoperative alpha adrenergic blockage with phenoxybenzamine or prazosin is important in decreasing the operative risk. Beta-blockers may be necessary for cardiac arrhythmia. Intraoperative invasive monitoring of hemodynamic variables may be both diagnostic and therapeutic of inadequate preoperative management. Lifelong follow-up for patients with pheochromocytoma is important

Modern imaging methods and preoperative management of pheochromocytoma: review of the literature and case report.

Abstract: OBJECTIVES: To discuss the modern imaging techniques and preoperative management of pheochromocytoma and to report on one additional case. METHODS: A 66-year-old male with an incidentally discovered left adrenal mass is described. The adrenal medulla strongly accumulate 131 I-metaiodobenzylguanidine (MIBG). The patient underwent left adrenalectomy after preoperative therapy with alpha and beta-blockers. The recent literature on pheochromocytoma modern imaging techniques and preoperative management is reviewed. RESULTS: MIBG scintigraphy diagnosed a benign functioning adrenal pheochromocytoma, allowing preoperative medical management. Postoperative workup was unremarkable. Diagnosis of pheochromocytoma was confirmed by immunohistopathology. At 18 months follow-up, the patient is alive and disease-free. CONCLUSIONS: Incidentally discovered adrenal masses have to be investigated to detect malignancy and subtle hormonal overproduction. MIBG scintigraphy has a high specificity (100%) in detecting pheochromocytoma, metastasis, surgical residual tumor, local relapse and other adrenal crest tumors. Positive results of octreotide scintigraphy in detecting malignant pheochromocytoma have been reported. Currently, pheochromocytoma removal is a safe operation with mortality rates ranging from 0 to less than 3%. Preoperative alpha adrenergic blockage with phenoxybenzamine or prazosin is important in decreasing the operative risk. Beta-blockers may be necessary for cardiac arrhythmia. Intraoperative invasive monitoring of hemodynamic variables may be both diagnostic and therapeutic of inadequate preoperative management. Lifelong follow-up for patients with pheochromocytoma is important

Multuple System Atrophy and Autonomic failure with early urogenital onset

Multuple System Atrophy and Autonomic failure with early urogenital onse

Relationship between pediatric hospital admissions for respiratory diseases and air pollution (PM10 and TSP) in Milan during the first semester 2007 and first semester 2008

The trend was analysed of hospital admissions to the Department of Pediatrics, San Paolo Hospital, Milan, Italy, with respect to respiratory diseases and daily levels of TSP (Total Suspended Particulate) and PM 10 (Particulate Matter < 10 \u3bcm), and a comparison was made between the first semester of 2007 and 2008. Since January 1, 2008, a municipal order was introduced (ECOPASS pollution charge), reducing vehicular traffic towards the city center. Respiratory disorders included the following: asthma or asthma like disorders; upper respiratory illness (pharyngitis, rhinitis, otitis), lower respiratory illness (bronchitits, bronchiolitis and pneumonia). The following results were obtained: there were 241 days (64,8%) with at least one hospital admission vs 122 (35,2%) with no hospital admission. Daily concentration of TSP significandy differed (p=0,03) between days with or without admission, whereas the difference between PM10 concentrations was not significant. The trend of hospital admissions was significantly different in days with both TSP and PM10 concentrations exceeding 60 \u3bcg/m3 (p < 0,05). In total, there were 226 admissions during the 1st semester 2007 vs 214 in the 1st semester 2008. The mean duration of hospitalization was also reduced (5,1 vs 4,5 days) (p = 0,009). The daily mean concentration of TSP was 48 \ub1 17,8 during 2007 vs 35,6 \ub1 17,5 during 2008 (p < 0,01). Present data support the hypothesis, that exposure to air pollutants causes detrimental effects on children respiratory health. The observed improval could be due to meteorological reasons, but also to the introduction of ECOPASS, which determined a reduction of vehicular traffic. Present data, even if preliminary, seem to suggest that even a modest reduction of pollutant concentration can have beneficial effects on children's respiratory health