Evaluation of the oesophagogastric cancer associated microbiome: a systematic review and quality assessment

Objective. Oesophagogastric cancer is the fifth most common cancer worldwide, with poor survival outcomes. The role of bacteria in the pathogenesis of oesophagogastric cancer remains poorly understood. Design. A systematic search identified studies assessing the oesophagogastric cancer microbiome. The primary outcome was to identify bacterial enrichment specific to oesophagogastric cancer. Secondary outcomes included appraisal of the methodology, diagnostic performance of cancer bacteria and the relationship between oral and tissue microbiome. Results. A total of 9295 articles were identified, and 87 studies were selected for analysis. Five genera were enriched in gastric cancer: Lactobacillus, Streptococcus, Prevotella, Fusobacterium and Veillonella. No clear trends were observed in oesophageal adenocarcinoma. Streptococcus, Prevotella and Fusobacterium were abundant in oesophageal squamous cell carcinoma. Functional analysis supports the role of immune cells, localised inflammation and cancer-specific pathways mediating carcinogenesis. STORMS reporting assessment identified experimental deficiencies, considering batch effects and sources of contamination prevalent in low-biomass samples. Conclusions. Functional analysis of cancer pathways can infer tumorigenesis within the cancer–microbe–immune axis. There is evidence that study design, experimental protocols and analytical techniques could be improved to achieve more accurate and representative results. Whole-genome sequencing is recommended to identify key metabolic and functional capabilities of candidate bacteria biomarkers

Telecommunications systems design techniques handbook

Handbook presents design and analysis of tracking, telemetry, and command functions utilized in these systems with particular emphasis on deep-space telecommunications. Antenna requirements are also discussed. Handbook provides number of tables outlining various performance criteria. Block diagrams and performance charts are also presented

Energy Efficient Residential Building Code for Arab Countries

This paper presents an energy analysis to support the Egyptian efforts to develop a New Energy Code for New Residential Buildings in the Arab Countries. Also, the paper represents a brief summary of the code contents specially, the effectiveness of building envelope and weather data in reducing electrical energy consumption. The impacts of the following parameters were studied namely; walls and roof constructions, window size and glazing type for different geographical locations in the Arab Countries. Two different distinguish weather classification were developed and analyzed and presented in this study, the DDC18.3& DDH 25. The first was developed by the Author to calculate DD using a mathematical model on electronic spread sheet. The second depends on the hourly values for each geographical location. The analysis includes the capitals and major cities representing most of the Arab countries. It was determined that the window to wall ratio (WWR) of 15% minimizes the total annual electricity use for the buildings. The Solar Factors (SF) and Window Orientation Factors (OF) were calculated for the eight wall orientations. The Over All Transfer Value (OTTV) was calculated for each orientation for different variables, e.g. WWR, Glazing Type, Shading, wall color and mid and top floor. The results show that the mass and types of building materials; WWR (15%), glass type and shutters; orientation; wall insulation (25mm), wall solar absorptivity (a=.3); roof insulation and shading effect enhance the thermal performance and reduces the cooling load by 60%

Pattern of Reaction Diffusion Front in Laminar Flows

Autocatalytic reaction between reacted and unreacted species may propagate as solitary waves, namely at a constant front velocity and with a stationary concentration profile, resulting from a balance between molecular diffusion and chemical reaction. The effect of advective flow on the autocatalytic reaction between iodate and arsenous acid in cylindrical tubes and Hele-Shaw cells is analyzed experimentally and numerically using lattice BGK simulations. We do observe the existence of solitary waves with concentration profiles exhibiting a cusp and we delineate the eikonal and mixing regimes recently predicted.Comment: 4 pages, 3 figures. This paper report on experiments and simulations in different geometries which test the theory of Boyd Edwards on flow advection of chemical reaction front which just appears in PRL (PRL Vol 89,104501, sept2002

Formation of atomic tritium clusters and condensates

We present an extensive study of the static and dynamic properties of systems of spin-polarized tritium atoms. In particular, we calculate the two-body |F,m_F>=|0,0> s-wave scattering length and show that it can be manipulated via a Feshbach resonance at a field strength of about 870G. Such a resonance might be exploited to make and control a Bose-Einstein condensate of tritium in the |0,0> state. It is further shown that the quartet tritium trimer is the only bound hydrogen isotope and that its single vibrational bound state is a Borromean state. The ground state properties of larger spin-polarized tritium clusters are also presented and compared with those of helium clusters.Comment: 5 pages, 3 figure

Reverse Doppler effect in backward spin waves scattered on acoustic waves

We report on the observation of reverse Doppler effect in backward spin waves reflected off of surface acoustic waves. The spin waves are excited in a yttrium iron garnet (YIG) film. Simultaneously, acoustic waves are also generated. The strain induced by the acoustic waves in the magnetostrictive YIG film results in the periodic modulation of the magnetic anisotropy in the film. Thus, in effect, a travelling Bragg grating for the spin waves is produced. The backward spin waves reflecting off of this grating exhibit a reverse Doppler shift: shifting down rather than up in frequency when reflecting off of an approaching acoustic wave. Similarly, the spin waves are shifted up in frequency when reflecting from receding acoustic waves.Comment: 4 pages, 3 figure

Promoting Mental Health and Wellbeing with Men and Boys: What Works?

In May 2014 the Movember Foundation commissioned the Centre for Men’s Health, Leeds Beckett University, in collaboration with the Men’s Health Forum (England & Wales), to gather the current research evidence and practical (‘tacit’) knowledge about the core elements that make for successful work with boys and men around mental health promotion, early intervention and stigma reduction

Successful mental health promotion with men: evidence from 'tacit knowledge'

There remains significant concern about men’s mental health, particularly in terms of personal and societal barriers to help-seeking, negative coping mechanisms and high suicide rates. This paper presents findings from a multi-phase study looking at ‘what works’ in mental health promotion for men. Work here reports the collection and analysis of the tacit knowledge of those working within mental health promotion interventions for men. A ‘multiple hub and spoke’ approach was used to assist data collection. Thirteen key players, active in the men’s mental health field, half from the UK and half beyond, formed an Investigative Network collecting data, mainly through interviews, from wider geographical and professional community contexts where they had networks. The focus of data collection was on ‘what works’ in mental health promotion for men. Data was analysed using thematic analysis techniques. Findings suggest that settings which created safe male spaces acted to promote trust, reduce stigma and normalise men’s engagement in interventions. Embedding interventions within the communities of men being engaged, fully involving these men, and holding ‘male-positive’ values engendered familiarity and consolidated trust. Using ‘male-sensitive’ language and activity-based approaches allowed for positive expressions of emotions, facilitated social engagement, and provided a base for open communication. Appropriate partnerships were also seen as a necessary requirement for success and as crucial for maximising intervention impact. The importance of gender and ‘masculinity’ was apparent throughout these findings and taking time to understand gender could facilitate positive ways of working alongside men, increasing levels of engagement and successful outcomes