Adaptive Equivalent Consumption Minimization Strategy with Rule-based Gear Selection for the Energy Management of Hybrid Electric Vehicles Equipped with Dual Clutch Transmissions

Based on observations of the behaviour of the optimal solution to the problem of energy management for plug-in hybrid electric vehicles, a novel real-time Energy Management Strategy (EMS) is proposed. In particular, dynamic programming results are used to derive a set of rules aiming at reproducing the optimal gearshift schedule in electric mode while the Adaptive Equivalent Consumption Minimization Strategy (A-ECMS) is employed to decide the powertrain operating mode and the current gear when power from the internal combustion engine is needed. In terms of total fuel consumption, simulations show that the proposed approach yields results that are close to the optimal solution and also outperforms those of the A-ECMS, a well-known EMS. One of the main aspects that differentiates the strategy here proposed from previous works is the introduction of a model to use physical considerations to estimate the energy consumption during gearshifts in dual-clutch transmissions. This, together with a series of properly tuned fuel penalties allows the controller to yield results in which there is no gear hunting behaviour

On the model-based design of front-to-total anti-roll moment distribution controllers for yaw rate tracking

In passenger cars active suspensions have been traditionally used to enhance comfort through body control, and handling through the reduction of the tyre load variations induced by road irregularities. However, active suspensions can also be designed to track a desired yaw rate profile through the control of the anti-roll moment distribution between the front and rear axles. The effect of the anti-roll moment distribution relates to the nonlinearity of tyre behaviour, which is difficult to capture in the linearised vehicle models normally used for control design. Hence, the tuning of anti-roll moment distribution controllers is usually based on heuristics. This paper includes an analysis of the effect of the lateral load transfer on the lateral axle force and cornering stiffness. A linearised axle force formulation is presented, and compared with a formulation from the literature, based on a quadratic relationship between cornering stiffness and load transfer. Multiple linearised vehicle models for control design are assessed in the frequency domain, and the respective controllers are tuned through optimisation routines. Simulation results from a nonlinear vehicle model are discussed to analyse the performance of the controllers, and show the importance of employing accurate models of the lateral load transfer effect during control design

Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates

Objectives: In a prospective, randomized trial, daptomycin was non-inferior to standard therapy for Staphylococcus aureus bacteraemia and right-sided endocarditis. Since rates of infection due to methicillin-resistant S. aureus (MRSA) infection are increasing and treatment outcomes for bacteraemia caused by MRSA are generally worse than those observed with methicillin-susceptible S. aureus bacteraemia, clinical characteristics and treatment results in the trial’s pre-specified subset of patients with MRSA were analysed. Methods: Clinical characteristics and outcomes of patients receiving daptomycin were compared with those receiving vancomycin plus low-dose gentamicin. Success was defined as clinical improvement with clearance of bacteraemia among patients who completed adequate therapy, received no potentially effective non-study antibiotics and had negative blood cultures 6 weeks after end of therapy. Results: Twenty of the 45 (44.4%) daptomycin patients and 14 of the 43 (32.6%) vancomycin/gentamicin patients were successfully treated (difference 11.9%; confidence interval −8.3 to 32.1). Success rates for daptomycin versus vancomycin/gentamicin were 45% versus 27% in complicated bacteraemia, 60% versus 45% in uncomplicated bacteraemia and 50% versus 50% in right-sided MRSA endocarditis. Cure rates in patients with septic emboli and in patients who received pre-enrolment vancomycin were similar between treatment groups. However, in both treatment groups, success rates were lower in the elderly (≥75 years). Persisting or relapsing bacteraemia occurred in 27% of daptomycin and 21% of vancomycin/gentamicin patients; among these patients, MICs of ≥2 mg/L occurred in five daptomycin and four vancomycin/gentamicin patients. The clinical course of several patients may have been influenced by lack of surgical intervention. Conclusions: Daptomycin was an effective alternative to vancomycin/gentamicin for MRSA bacteraemia or right-sided endocarditis

Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus.

BACKGROUND: Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed. METHODS: We randomly assigned 124 patients with S. aureus bacteremia with or without endocarditis to receive 6 mg of daptomycin intravenously per kilogram of body weight daily and 122 to receive initial low-dose gentamicin plus either an antistaphylococcal penicillin or vancomycin. The primary efficacy end point was treatment success 42 days after the end of therapy. RESULTS: Forty-two days after the end of therapy in the modified intention-to-treat analysis, a successful outcome was documented for 53 of 120 patients who received daptomycin as compared with 48 of 115 patients who received standard therapy (44.2 percent vs. 41.7 percent; absolute difference, 2.4 percent; 95 percent confidence interval, -10.2 to 15.1 percent). Our results met prespecified criteria for the noninferiority of daptomycin. The success rates were similar in subgroups of patients with complicated bacteremia, right-sided endocarditis, and methicillin-resistant S. aureus. Daptomycin therapy was associated with a higher rate of microbiologic failure than was standard therapy (19 vs. 11 patients, P=0.17). In 6 of the 19 patients with microbiologic failure in the daptomycin group, isolates with reduced susceptibility to daptomycin emerged; similarly, a reduced susceptibility to vancomycin was noted in isolates from patients treated with vancomycin. As compared with daptomycin therapy, standard therapy was associated with a nonsignificantly higher rate of adverse events that led to treatment failure due to the discontinuation of therapy (17 vs. 8, P=0.06). Clinically significant renal dysfunction occurred in 11.0 percent of patients who received daptomycin and in 26.3 percent of patients who received standard therapy (P=0.004). CONCLUSIONS: Daptomycin (6 mg per kilogram daily) is not inferior to standard therapy for S. aureus bacteremia and right-sided endocarditis. (ClinicalTrials.gov number, NCT00093067 [ClinicalTrials.gov].)

Metastatic potential of an aneurysmal bone cyst

Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa. Recently, the hypothesis that ABCs are lesions reactive to local hemodynamics has been challenged after the discovery of specific recurrent chromosomal abnormalities. Multiple cases of malignant transformation of ABC into (osteo)sarcoma have been described, as well as a number of cases of telangiectatic osteosarcoma which had been misdiagnosed as ABC. We herewith document a case of a pelvic ABC metastatic to the lung, liver, and kidneys. Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient. Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor

On the model-based design of front-to-total anti-roll moment distribution controllers for yaw rate tracking

In passenger cars active suspensions have been traditionally used to enhance comfort through body control, and handling through the reduction of the tyre load variations induced by road irregularities. However, active suspensions can also be designed to track a desired yaw rate profile through the control of the anti-roll moment distribution between the front and rear axles. The effect of the anti-roll moment distribution relates to the nonlinearity of tyre behaviour, which is difficult to capture in the linearised vehicle models normally used for control design. Hence, the tuning of anti-roll moment distribution controllers is usually based on heuristics. This paper includes an analysis of the effect of the lateral load transfer on the lateral axle force and cornering stiffness. A linearised axle force formulation is presented, and compared with a formulation from the literature, based on a quadratic relationship between cornering stiffness and load transfer. Multiple linearised vehicle models for control design are assessed in the frequency domain, and the respective controllers are tuned through optimisation routines. Simulation results from a nonlinear vehicle model are discussed to analyse the performance of the controllers, and show the importance of employing accurate models of the lateral load transfer effect during control design