Non-hermitian approach to decaying ultracold bosonic systems

A paradigm model of modern atom optics is studied, strongly interacting ultracold bosons in an optical lattice. This many-body system can be artificially opened in a controlled manner by modern experimental techniques. We present results based on a non-hermitian effective Hamiltonian whose quantum spectrum is analyzed. The direct access to the spectrum of the metastable many-body system allows us to easily identify relatively stable quantum states, corresponding to previously predicted solitonic many-body structures

The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus

Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply modifications in dendritic cytoskeleton. Rho GTPases are regulators of actin dynamics through their effector Rho kinase. We have reported that chronic stress promotes depressive-like behaviors in rats along with dendritic spine loss in apical dendrites of hippocampal pyramidal neurons, changes associated with Rho kinase activation. The present study proposes that the Rho kinase inhibitor Fasudil may prevent the stress-induced behavior and dendritic spine loss. Methods: Adult male Sprague-Dawley rats were injected with saline or Fasudil (i.p., 10 mg/kg) starting 4 days prior to and maintained during the restraint stress procedure (2.5 h/d for 14 days). Nonstressed control animals were injected with saline or Fasudil for 18 days. At 24 hours after treatment, forced swimming test, Golgi-staining, and immuno-western blot were performed. Results: Fasudil prevented stress-induced immobility observed in the forced swimming test. On the other hand, Fasudiltreated control animals showed behavioral patterns similar to those of saline-treated controls. Furthermore, we observed that stress induced an increase in the phosphorylation of MYPT1 in the hippocampus, an exclusive target of Rho kinase. This change was accompanied by dendritic spine loss of apical dendrites of pyramidal hippocampal neurons. Interestingly, increased pMYPT1 levels and spine loss were both prevented by Fasudil administration. Conclusion: Our findings suggest that Fasudil may prevent the development of abnormal behavior and spine loss induced by chronic stress by blocking Rho kinase activity.https://academic.oup.com/ijnp/article/20/4/336/263217

Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats

Indexación: Web of Science; Scopus.Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Adult male Sprague-Dawley rats were randomly divided into control and stressed groups, and were daily restrained in their motion (2.5 h/day) during 14 days. We found that chronic stress promotes an increase in c-Fos mRNA levels in both hippocampal areas, although it was observed a reduction in the immunoreactivity at pyramidal cell layer. Furthermore, Arc mRNAs levels were increased in both dorsal and VH, accompanied by an increase in Arc immunoreactivity in dendritic hippocampal layers. Furthermore, stress triggered a reduction in PSD-95 and NR1 protein levels in whole extract of dorsal and VH. Moreover, a reduction in NR2A/NR2B ratio was observed only in dorsal pole. In synaptosomal fractions, we detected a rise in NR1 in dorsal hippocampus (DH). By indirect immunofluorescence we found that NR1 subunits rise, especially in neuropil areas of dorsal, but not VH. In relation to AMPA receptor (AMPAR) subunits, chronic stress did not trigger any change, either in dorsal or ventral hippocampal areas. These data suggest that DH is more sensitive than VH to chronic stress exposure, mainly altering the expression of NMDA receptor (NMDAR) subunits, and probably favors changes in the configuration of this receptor that may influence the function of this area.https://www.frontiersin.org/articles/10.3389/fnmol.2017.00244/ful

Turbulent transport in tokamak plasmas with rotational shear

Nonlinear gyrokinetic simulations have been conducted to investigate turbulent transport in tokamak plasmas with rotational shear. At sufficiently large flow shears, linear instabilities are suppressed, but transiently growing modes drive subcritical turbulence whose amplitude increases with flow shear. This leads to a local minimum in the heat flux, indicating an optimal E x B shear value for plasma confinement. Local maxima in the momentum fluxes are also observed, allowing for the possibility of bifurcations in the E x B shear. The sensitive dependence of heat flux on temperature gradient is relaxed for large flow shear values, with the critical temperature gradient increasing at lower flow shear values. The turbulent Prandtl number is found to be largely independent of temperature and flow gradients, with a value close to unity.Comment: 4 pages, 5 figures, submitted to PR

Considering Fluctuation Energy as a Measure of Gyrokinetic Turbulence

In gyrokinetic theory there are two quadratic measures of fluctuation energy, left invariant under nonlinear interactions, that constrain the turbulence. The recent work of Plunk and Tatsuno [Phys. Rev. Lett. 106, 165003 (2011)] reported on the novel consequences that this constraint has on the direction and locality of spectral energy transfer. This paper builds on that work. We provide detailed analysis in support of the results of Plunk and Tatsuno but also significantly broaden the scope and use additional methods to address the problem of energy transfer. The perspective taken here is that the fluctuation energies are not merely formal invariants of an idealized model (two-dimensional gyrokinetics) but are general measures of gyrokinetic turbulence, i.e. quantities that can be used to predict the behavior of the turbulence. Though many open questions remain, this paper collects evidence in favor of this perspective by demonstrating in several contexts that constrained spectral energy transfer governs the dynamics.Comment: Final version as published. Some cosmetic changes and update of reference

Ion-scale turbulence in MAST: anomalous transport, subcritical transitions, and comparison to BES measurements

We investigate the effect of varying the ion temperature gradient (ITG) and toroidal equilibrium scale sheared flow on ion-scale turbulence in the outer core of MAST by means of local gyrokinetic simulations. We show that nonlinear simulations reproduce the experimental ion heat flux and that the experimentally measured values of the ITG and the flow shear lie close to the turbulence threshold. We demonstrate that the system is subcritical in the presence of flow shear, i.e., the system is formally stable to small perturbations, but transitions to a turbulent state given a large enough initial perturbation. We propose that the transition to subcritical turbulence occurs via an intermediate state dominated by low number of coherent long-lived structures, close to threshold, which increase in number as the system is taken away from the threshold into the more strongly turbulent regime, until they fill the domain and a more conventional turbulence emerges. We show that the properties of turbulence are effectively functions of the distance to threshold, as quantified by the ion heat flux. We make quantitative comparisons of correlation lengths, times, and amplitudes between our simulations and experimental measurements using the MAST BES diagnostic. We find reasonable agreement of the correlation properties, most notably of the correlation time, for which significant discrepancies were found in previous numerical studies of MAST turbulence.Comment: 67 pages, 37 figures. Submitted to PPC

Zero-Turbulence Manifold in a Toroidal Plasma

Sheared toroidal flows can cause bifurcations to zero-turbulent-transport states in tokamak plasmas. The maximum temperature gradients that can be reached are limited by subcritical turbulence driven by the parallel velocity gradient. Here it is shown that q/\epsilon (magnetic field pitch/inverse aspect ratio) is a critical control parameter for sheared tokamak turbulence. By reducing q/\epsilon, far higher temperature gradients can be achieved without triggering turbulence, in some instances comparable to those found experimentally in transport barriers. The zero-turbulence manifold is mapped out, in the zero-magnetic-shear limit, over the parameter space (\gamma_E, q/\epsilon, R/L_T), where \gamma_E is the perpendicular flow shear and R/L_T is the normalised inverse temperature gradient scale. The extent to which it can be constructed from linear theory is discussed.Comment: 5 Pages, 4 Figures, Submitted to PR

Transport Bifurcation in a Rotating Tokamak Plasma

The effect of flow shear on turbulent transport in tokamaks is studied numerically in the experimentally relevant limit of zero magnetic shear. It is found that the plasma is linearly stable for all non-zero flow shear values, but that subcritical turbulence can be sustained nonlinearly at a wide range of temperature gradients. Flow shear increases the nonlinear temperature gradient threshold for turbulence but also increases the sensitivity of the heat flux to changes in the temperature gradient, except over a small range near the threshold where the sensitivity is decreased. A bifurcation in the equilibrium gradients is found: for a given input of heat, it is possible, by varying the applied torque, to trigger a transition to significantly higher temperature and flow gradients.Comment: 4 pages, 4 figures, submitted to PR