Measurement of the Spin-Dependence of the pbar-p Interaction at the AD-Ring

We propose to use an internal polarized hydrogen storage cell gas target in the AD ring to determine for the first time the two total spin-dependent pbar-p cross sections sigma_1 and sigma_2 at antiproton beam energies in the range from 50 to 450 MeV. The data obtained are of interest by themselves for the general theory of pbar-p interactions since they will provide a first experimental constraint of the spin-spin dependence of the nucleon-antinucleon potential in the energy range of interest. In addition, measurements of the polarization buildup of stored antiprotons are required to define the optimum parameters of a future, dedicated Antiproton Polarizer Ring (APR), intended to feed a double-polarized asymmetric pbar-p collider with polarized antiprotons. Such a machine has recently been proposed by the PAX collaboration for the new Facility for Antiproton and Ion Research (FAIR) at GSI in Darmstadt, Germany. The availability of an intense stored beam of polarized antiprotons will provide access to a wealth of single- and double-spin observables, thereby opening a new window on QCD spin physics.Comment: 51 pages, 23 figures, proposal submitted to the SPS committee of CER

Polarizing a stored proton beam by spin flip?

We discuss polarizing a proton beam in a storage ring, either by selective removal or by spin flip of the stored ions. Prompted by recent, conflicting calculations, we have carried out a measurement of the spin-flip cross section in low-energy electron-proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam. This invalidates a recent proposal to use co-moving polarized positrons to polarize a stored antiproton beam. (C) 2009 Elsevier B.V. All rights reserved

Measurement of the Spin–Dependence of the p‾−p\overline{p}-p Interaction at the AD–Ring

We propose to use an internal polarized hydrogen storage cell gas target in the AD ring to determine for the first time the two total spin–dependent pbar-p cross sections σ1 and σ2 at antiproton beam energies in the range from 50 to 450 MeV. The data obtained are of interest by themselves for the general theory of pbar-p interactions since they will provide a first experimental constraint of the spin–spin dependence of the nucleon–antinucleon potential in the energy range of interest. In addition, measurements of the polarization buildup of stored antiprotons are required to define the optimum parameters of a future, dedicated Antiproton Polarizer Ring (APR), intended to feed a double–polarized asymmetric pbar-p collider with polarized antiprotons. Such a machine has recently been proposed by the PAX collaboration for the new Facility for Antiproton and Ion Research (FAIR) at GSI in Darmstadt, Germany. The availability of an intense stored beam of polarized antiprotons will provide access to a wealth of single– and double–spin observables, thereby opening a new window on QCD spin physics. A recent experiment at COSY revealed that ep spin–flip cross sections are too small to cause a detectable depolarization of a stored proton beam. This measurement rules out a proposal to use polarized positrons to polarize an antiproton beam by e+pbar spin–flip interactions. Thus, our approach to provide a beam of polarized antiprotons is based on spin filtering, using an internal polarized hydrogen gas target – a method that has been tested with stored protons. We expect to produce a polarized antiproton beam with at least ten orders of magnitude higher intensity than a secondary polarized antiproton beam previously available. Provided that antiproton beams with a polarization of about 15% can be obtained with the APR, the antiproton machine at FAIR (the High Energy Storage Ring) could be converted into a double–polarized asymmetric pbar-p collider by installation of an additional COSY–like ring. In this setup, antiprotons of 3.5 GeV/c collide with protons of 15 GeV/c at c.m. energies of √s ≈ √200 GeV with a luminosity in excess of 10^31 cm−2s−1. The PAX physics program proposed for FAIR has been highly rated, and would include, most importantly, a first direct measurement of the transversity distribution of the valence quarks in the proton, and a first measurement of the moduli and the relative phase of the time–like electric and magnetic form factors G_E,M of the proton.We propose to use an internal polarized hydrogen storage cell gas target in the AD ring to determine for the first time the two total spin-dependent pbar-p cross sections sigma_1 and sigma_2 at antiproton beam energies in the range from 50 to 450 MeV. The data obtained are of interest by themselves for the general theory of pbar-p interactions since they will provide a first experimental constraint of the spin-spin dependence of the nucleon-antinucleon potential in the energy range of interest. In addition, measurements of the polarization buildup of stored antiprotons are required to define the optimum parameters of a future, dedicated Antiproton Polarizer Ring (APR), intended to feed a double-polarized asymmetric pbar-p collider with polarized antiprotons. Such a machine has recently been proposed by the PAX collaboration for the new Facility for Antiproton and Ion Research (FAIR) at GSI in Darmstadt, Germany. The availability of an intense stored beam of polarized antiprotons will provide access to a wealth of single- and double-spin observables, thereby opening a new window on QCD spin physics

Measurement of Spin Observables in the ~p ~d Breakup Reaction

We update our Letter-of-Intent 202 for Measurement of Spin Observables in the ~p ~d Breakup Reaction. An estimate of the overall beam time needed for completing the measurements is specied and a timeline in view of the planned PAX experiments is presented. The proposal aims at a study of the three nucleon continuum in proton deuteron breakup reactions, between 30 and 50 MeV proton beam energies, an energy range where there have been few and limited measurements. The large coverage of the PAX detection setup and the energy range chosen will provide essential new data intended as a laboratory for chiral eective eld theory, the modern theory for nuclear forces relevant at low and intermediate energies. Vector and tensor analyzing powers and spin correlation coecients will be measured and evaluated over large kinematical areas in the ve parameter phase space of the nal state containing three nucleons. For the analysis the sampling method will be used, a technique developed specically for the complex analysis of three particle nal states, providing a direct comparison between experiment and theory

Effect of the anti-retroviral drug, rilpivirine, on human subcutaneous adipose cells and its nutritional management using quercetin

Rilpivirine, a recently developed drug of choice for initial treatment of HIV-1 infection, can greatly reduce HIV-related inflammation, but in turn, may be associated with adverse secondary effects, including disturbances in lipid metabolism and ultimately in adipose tissue distribution and function. In recent years, research findings on the benefits of anti-oxidant foods and supplements have been employed in counter-acting both oxidative stress as well as inflammation in order to reduce the adverse side effects of anti-retroviral therapy. One such natural flavonoid which possesses anti-inflammatory and anti-oxidative properties is quercetin. This study investigated the effect of quercetin in overcoming the side effects incurred due to rilpivirine administration. The results show substantial reduction in the accumulation of triglyceride levels in a dose- and time- dependent manner for adipose cells treated with either rilpivirine or quercetin alone and in combination, as evidenced by morphological pictures and quantitative measurement of triglycerides throughout the differentiation process. Levels of inflammatory markers such as resistin and IL-8 were increased as compared to the untreated cells. No significant changes in leptin were observed on treatment of adipose cells with rilpivirine alone and its levels were almost comparable to control. Levels of oxidative markers like superoxide dismutase, catalase and glutathione were also decreased. Treatment with quercetin showed a decrease in the inflammatory status and an increase in the oxidative status of adipose cells, thereby, exhibiting its anti-inflammatory and anti-oxidative properties. However, further assessment of lipid metabolism and adipose tissue function in patients administered with rilpivirine-based regimes is advisable considering that totally neutral effects of rilpivirine on lipid homeostasis cannot be anticipated from the current study in vitro. It is concluded that rilpivirine causes an anti-adipogenic and pro-inflammatory response pattern but only at high concentrations, whereas quercetin has been observed to decrease inflammation and restore the levels of anti-oxidant enzyme