Dynamics of quantum spin chains and multi-fermion excitation continua

We use the Jordan-Wigner representation to study dynamic quantities for the spin-1/2 XX chain in a transverse magnetic field. We discuss in some detail the properties of the four-fermion excitation continuum which is probed by the dynamic trimer structure factor.Comment: Presented at the SCES '05 - The International Conference on Strongly Correlated Electron Systems (Vienna, July 26-30, 2005

The Development of a Direct Homologous Radioimmunoassay for Serum Cortisol

Peer Reviewe

Automated Reconstruction of Particle Cascades in High Energy Physics Experiments

We present a procedure for reconstructing particle cascades from event data measured in a high energy physics experiment. For evaluating the hypothesis of a specific physics process causing the observed data, all possible reconstruction versions of the scattering process are constructed from the final state objects. We describe the procedure as well as examples of physics processes of different complexity studied at hadron-hadron colliders. We estimate the performance by 20 microseconds per reconstructed decay vertex, and 0.6 kByte per reconstructed particle in the decay trees.Comment: 8 pages, 2 figures. Submitted to Computational Science & Discover

SAFT-γ force field for the simulation of molecular fluids: 4. A single-site coarse-grained model of water applicable over a wide temperature range

In this work, we develop coarse-grained (CG) force fields for water, where the effective CG intermolecular interactions between particles are estimated from an accurate description of the macroscopic experimental vapour-liquid equilibria data by means of a molecular-based equation of state. The statistical associating fluid theory for Mie (generalised Lennard-Jones) potentials of variable range (SAFT-VR Mie) is used to parameterise spherically symmetrical (isotropic) force fields for water. The resulting SAFT-γ CG models are based on the Mie (8-6) form with size and energy parameters that are temperature dependent; the latter dependence is a consequence of the angle averaging of the directional polar interactions present in water. At the simplest level of CG where a water molecule is represented as a single bead, it is well known that an isotropic potential cannot be used to accurately reproduce all of the thermodynamic properties of water simultaneously. In order to address this deficiency, we propose two CG potential models of water based on a faithful description of different target properties over a wide range of temperatures: our CGW1-vle model is parameterised to match the saturated-liquid density and vapour pressure; our other CGW1-ift model is parameterised to match the saturated-liquid density and vapour-liquid interfacial tension. A higher level of CG corresponding to two water molecules per CG bead is also considered: the corresponding CGW2-bio model is developed to reproduce the saturated-liquid density and vapour-liquid interfacial tension in the physiological temperature range, and is particularly suitable for the large-scale simulation of bio-molecular systems. A critical comparison of the phase equilibrium and transport properties of the proposed force fields is made with the more traditional atomistic models

Ray-tracing in pseudo-complex General Relativity

Motivated by possible observations of the black hole candidate in the center of our galaxy and the galaxy M87, ray-tracing methods are applied to both standard General Relativity (GR) and a recently proposed extension, the pseudo-complex General Relativity (pc-GR). The correction terms due to the investigated pc-GR model lead to slower orbital motions close to massive objects. Also the concept of an innermost stable circular orbit (ISCO) is modified for the pc-GR model, allowing particles to get closer to the central object for most values of the spin parameter $a$ than in GR. Thus, the accretion disk, surrounding a massive object, is brighter in pc-GR than in GR. Iron K$\alpha$ emission line profiles are also calculated as those are good observables for regions of strong gravity. Differences between the two theories are pointed out.Comment: revised versio

Proteomic analysis of embryonic kidney development: Heterochromatin proteins as epigenetic regulators of nephrogenesis

Elucidation of the mechanisms underlying the nephrogenesis will boost enormously the regenerative medicine. Here we performed 2-D gel-based comparative proteome analyses of rat embryonic kidney from different developmental stages. Out of 288 non-redundant identified proteins, 102 were common in all developmental stages. 86% of the proteins found in E14 and E16 were identical, in contrast only 37% of the identified proteins overlap between E14 and P1. Bioinformatics analysis suggests developmental stage-specific pathway activation and highlighted heterochromatin protein 1 (Cbx1, Cbx3, Cbx5) and Trim28 as potential key players in nephrogenesis. These are involved in the epigenetic regulation of gene silencing and were down-regulated in the course of kidney development. Trim28 is a potential epigenetic regulator of the branching inhibitor Bmp4. Silencing of Trim28 in cultured kidneys resulted in branching arrest. In contrast knockdown of Cbx5 was associated with abnormal ureteric bud growth and slight impairment of branching. ChIP analysis showed that the H3K9me3 distribution on Bmp4 promoters at E14 and E19 inversely correlate with mRNA expression levels. The concentrated expression-pattern of heterochromatin proteins and the negative impact of their silencing on kidney development, suggest an important role in reciprocal and inductive signaling between the ureteric bud and the metanephric mesenchyme