Statistical properties of Fermi GBM GRBs' spectra

Statistical studies of gamma-ray burst (GRB) spectra may result in important information on the physics of GRBs. The Fermi GBM catalog contains GRB parameters (peak energy, spectral indices, intensity) estimated fitting the gamma-ray SED of the total emission (fluence, flnc), and during the time of the peak flux pflx. Using contingency tables we studied the relationship of the models best fitting pflx and flnc time intervals. Our analysis revealed an ordering of the spectra into a power law - Comptonized - smoothly broken power law - Band series. This result was further supported by a correspondence analysis (CA) of the pflx and flnc spectra categorical variables. We performed a linear discriminant analysis (LDA) to find a relationship between categorical (spectral) and model independent physical data. LDA resulted in highly significant physical differences among the spectral types, that is more pronounced in the case of the pflx spectra, than for the flnc spectra. We interpreted this difference as caused by the temporal variation of the spectrum during the outburst. This spectral variability is confirmed by the differences in the low energy spectral index and peak energy, between the pflx and flnc spectra. We found that the synchrotron radiation is significant in GBM spectra. The mean low energy spectral index is close to the canonical value of {\alpha} = -2/3 during the peak flux. However, $\alpha$ is ~ -0.9 for the spectra of the fluences. We interpret this difference as showing that the effect of cooling is important only for the fluence spectra.Comment: Manuscript accepted for publication in MNRA

A cukorbeteg-ellátás mutatóinak alakulása Magyarországon 2001–2014 között. Az Országos Egészségbiztosítási Pénztár adatbázis-elemzésének célja és módszertana

In the last couple of years, database analyses have become increasingly popular among clinical-epidemiological investigations. In Hungary, the National Health Insurance Fund serves as central database of all medical attendances in state departments and purchases of drug prescriptions in pharmacies. Data from in- and outpatient departments as well as those from pharmacies are regularly collected in this database which is public and accessible on request. The aim of this retrospective study was to investigate the database of the National Health Insurance Fund in order to analyze the diabetes-associated morbidity and mortality in the period of years 2001-2014. Moreover, data of therapeutic costs, features of hospitalizations and practice of antidiabetic treatment were examined. The authors report now on the method of the database analysis. It is to be hoped that the upcoming results of this investigation will add some new data to recent knowledge about diabetes care in Hungary. Orv. Hetil., 2016, 157(32), 1259-1265

Characterization of Defect Structure in Electrodeposited Nanocrystalline Ni Films

The microstructure of electrodeposited Ni films produced without and with organic additives (saccharin and formic acid) was investigated by X-ray diffraction (XRD) line profile analysis and cross-sectional transmission electron microscopy (TEM). Whereas the general effect of these additives on the microstructure (elimination of columnar growth as well as grain refinement) was reproduced, the pronounced intention of this study was to compare the results of various seldom-used high-performance structural characterization methods on identical electrodeposited specimens in order to reveal fine details of structural changes qualitatively not very common in this field. In the film deposited without additives, a columnar structure was observed showing similarities to the T-zone of structure zone models. Both formic acid and saccharin additives resulted in equiaxed grains with reduced size, as well as increased dislocation and twin fault densities in the nanocrystalline films. Moreover, the structure became homogeneous and free of texture within the total film thickness due to the additives. Saccharin yielded smaller grain size and larger defect density than formic acid. A detailed analysis of the grain size and twin boundary spacing distributions was carried out with the complementary application of TEM and XRD, by carefully distinguishing between the TEM and XRD grain sizes.Comment: 26 pages, 11 figure

Transient detection capabilities of small satellite gamma-ray detectors

The new, small satellite-based gamma-ray detectors, like Cubesats Applied for MEasuring and Localizing Transients, will provide a new wa to detect gamma transients in the multimessenger era. The efficiency an the detection capabilities of such a system will be compared wit current missions, for example, Fermi Gamma-ray Burst Monitor (GBM). W used the Fermi GBM's observed short gamma-ray burst light curve aggregated from observed discrete detector event for the simulatio input. The corresponding direction-dependent detector response matrice were used to generate photon counts and light curves around a simulate event, enabling to determine the statistics. This method can be used i the future for trigger algorithm and detector system development, an also to estimate the efficiency of the data analysis pipeline regardin the observable gamma-ray bursts' parameters as well as othe electromagnetic transient

A 2-es típusú diabetes antihyperglykaemiás kezelésének alakulása Magyarországon 2001–2014 között – az Országos Egészségbiztosítási Pénztár adatbázis-elemzésének eredményei

In the last couple of years, significant developments in antidiabetic treatment have influenced the pharmacological treatment of type 2 diabetes mellitus (T2DM). The aim of this study was to analyze the changes in prescribing patterns of glucose-lowering drugs for T2DM patients in Hungary between 2001 and 2014. The number of patients with newly diagnosed T2DM decreased from 75,700 (2001) to 33,700 (2014), while prevalent T2DM cases continuously increased and plateaued in 2014 with a number of registered patients of 727,000. Sulfonylurea-monotherapy decreased from 64% to 35% while metformin-monotherapy increased from 19% to 42% in this period. The most frequently used drug at first treatment initiation was metformin (66%) and sulfonylurea (16%) as monotherapy in 2014. DPP4-inhibitors were newly administered in 20,362 cases while GLP1-mimetics were newly used by 4,996 patients in 2014. Five years later after initiating sulfonylurea therapy between 2010 and 2014, metformin was more frequently used as second drug (39%) than sulfonylurea in patients with previous metformin treatment (22.9%). The prescribing patterns of glucose-lowering drugs have changed over time in accordance with new guidelines. Further changes in prescribing habits can be expected in the near future. Orv Hetil. 2017; 158(20): 770-778

Herpesvirus-mediated delivery of a genetically encoded fluorescent Ca2+ sensor to canine cardiomyocytes

We report the development and application of a pseudorabies virus-based system for delivery of troponeon, a fluorescent Ca2+ sensor to adult canine cardiomyocytes. The efficacy of transduction was assessed by calculating the ratio of fluorescently labelled and nonlabelled cells in cell culture. Interaction of the virus vector with electrophysiological properties of cardiomyocytes was evaluated by the analysis of transient outward current (Ito), kinetics of the intracellular Ca2+ transients, and cell shortening. Functionality of transferred troponeon was verified by FRET analysis. We demonstrated that the transfer efficiency of troponeon to cultured adult cardiac myocytes was virtually 100%. We showed that even after four days neither the amplitude nor the kinetics of the Ito current was significantly changed and no major shifts occurred in parameters of [Ca2+]i transients. Furthermore, we demonstrated that infection of cardiomyocytes with the virus did not affect the morphology, viability, and physiological attributes of cells

β-estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

17 β - estradiol (E2) and 17 α - ethinyl estradiol (EE2), wh ich are environmental estrogens have been determined with LC - MS in freshwater. Their sensitive analysis needs derivatisation and therefore is very hard to ac hieve in multiresidue screening . We analysed samples from all the large and some small rivers (River Danube, Drava, Mur, Sava, Tisza and Zala) of the Carpathian Basin and from Lake Balaton. Freshwater was extracted on solid phase and derivatised using dansyl - chloride. Separation was per formed on a Kinetex XB - C18 column. Detection was achieved with a benchtop orbitrap mass spectrometer using targeted MS analysis for quantification. Limits of quantification were 0.05 ng/L (MS1) and 0.1 ng/L (MS/MS ) for E2, and 0.001 ng/L (MS1) and 0.2 ng/L (MS/MS ) for EE2. River samples contained n.d. - 5.2 ng/L E2 and n.d. - 0.68 ng/L EE2. Average levels of E2 and EE2 were 0.6 1 and 0.084 ng/L respectively in rivers, water courses and Lake Balaton together, but not counting city canal water . EE2 was less abunda nt, but it was still present in almost all of the samples. In b each water samples from Lake Balaton we measured 0.076 - 0.233 E2 and n.d. - 0.133 EE2. A relative high amount of EE2 was found in river Zala (0.68 ng/L) and in Hévíz - P áhoki canal (0.52 ng/L), whic h are both in the catchment area of Lake Balaton (Hungary)