924 research outputs found
Nutritional basis of type 2 diabetes remission.
Roy Taylor and colleagues explain how type 2 diabetes can be reversed by weight loss and avoidance of weight regai
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Dietary and nutritional approaches for prevention and management of type 2 diabetes.
Common ground on dietary approaches for the prevention, management, and potential remission of type 2 diabetes can be found, argue Nita G Forouhi and colleagues
Dietary factors are of paramount importance in the management and prevention of type 2 diabetes. Despite progress in formulating evidence based dietary guidance, controversy and confusion remain. In this article, we examine the evidence for areas of consensus as well as ongoing uncertainty or controversy about dietary guidelines for type 2 diabetes. What is the best dietary approach? Is it possible to achieve remission of type 2 diabetes with lifestyle behaviour changes or is it inevitably a condition causing progressive health decline? We also examine the influence of nutrition transition and population specific factors in the global context and discuss future directions for effective dietary and nutritional approaches to manage type 2 diabetes and their implementation.NGF receives funding from the Medical Research Council Epidemiology Unit (MC_UU_12015/5)
The Bolocam Galactic Plane Survey. XIV. Physical Properties of Massive Starless and Star Forming Clumps
We sort molecular clouds between from the
Bolocam Galactic Plane Survey based on observational diagnostics of star
formation activity: compact sources, mid-IR color-selected
YSOs, and masers, and UCHII regions. We also
present a combined -derived gas kinetic temperature and maser catalog for clumps from our own GBT 100m observations and
from the literature. We identify a subsample of () starless
clump candidates, the largest and most robust sample identified from a blind
survey to date. Distributions of flux density, flux concentration, solid angle,
kinetic temperature, column density, radius, and mass show strong ( dex)
progressions when sorted by star formation indicator. The median starless clump
candidate is marginally sub-virial () with of clumps
with known distance being gravitationally bound (). These samples
show a statistically significant increase in the median clump mass of M from the starless candidates to clumps associated with
protostars. This trend could be due to (i) mass growth of the clumps at
Msun Myr for an average free-fall Myr
time-scale, (ii) a systematic factor of two increase in dust opacity from
starless to protostellar phases, (iii) and/or a variation in the ratio of
starless to protostellar clump lifetime that scales as . By
comparing to the observed number of maser containing clumps we
estimate the phase-lifetime of massive ( M) starless clumps to
be ; the majority
( M) have phase-lifetimes longer than their average free-fall
time.Comment: Accepted for publication in ApJ; 33 pages; 22 figures; 7 table
Financial Analysis of Dalbavancin for Acute Bacterial Skin and Skin Structure Infections for Self-Pay Patients
© 2020, The Author(s). Introduction: Acute bacterial skin and skin structure infections (ABSSSI) are an increasing cause of admission in the self-pay population. We previously reported that patients with ABSSSI discharged to receive dalbavancin showed a decreased length of stay (LOS) and total direct costs without increasing 30-day readmission rate. For patients who are financially eligible, a dalbavancin vial replacement program can offset costs. The objective of this study was to determine cost differences in treating ABSSSI in self-pay inpatients discharged to receive dalbavancin compared to standard of care (SOC). Methods: This retrospective cohort within a community health system compared self-pay adult inpatients with ABSSSI from February 3, 2016 to August 5, 2019 discharged to receive dalbavancin at an outpatient infusion center with SOC intravenous antibiotics. Patients were included with cellulitis, abscess, or postoperative wound infections diagnoses on the basis of International Classification of Disease, Tenth Revision (ICD-10) codes. Excluded populations were patients without dalbavancin vial replacement performed, pregnant, infections caused exclusively by gram-negative bacteria or fungi, or ICD-10 codes not consistent with ABSSSI. The primary outcome was direct cost of hospital stay. Secondary outcomes included length of stay (LOS), 30-day readmission rates, adverse events (AE), and indirect hospital costs. On the basis of previous studies, a one-sided Student’s t test was performed on financial data. Results: Twelve dalbavancin and 263 SOC patients met inclusion criteria. Direct cost (4010, p = 0.105) and indirect hospital cost (3646 , p = 0.162) per patient were less in the dalbavancin group. There was no significant difference between median LOS (4 vs 4, p = 0.888), AE (0% vs 14.8%), and 30-day readmission rates for dalbavancin vs SOC group (8.3% vs 7.2%, p = 0.604). Conclusion: Self-pay patients with ABSSSI discharged to receive dalbavancin with vial replacement resulted in decreased direct and indirect costs per patient with similar 30-day readmission rates, AE, and LOS. More studies targeted toward this population are warranted to determine ultimate benefit
Distributed Dynamic Density Coverage for Human-Swarm Interactions
© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.DOI: 10.1109/ACC.2015.7170761This paper presents two approaches to externally
influence a team of robots by means of time-varying
density functions. These density functions represent rough
references for where the robots should be located. Recently
developed continuous-time algorithms move the robots so
as to provide optimal coverage of a given the time-varying
density functions. This makes it possible for a human
operator to abstract away the number of robots and
focus on the general behavior of the team of robots as a
whole. Using a distributed approximation to this algorithm
whereby the robots only need to access information from
adjacent robots allows these algorithms to scale well with
the number of robots. Simulations and robotic experiments
show that the desired behaviors are achieved
The Detection and Characterization of cm Radio Continuum Emission from the Low-mass Protostar L1014-IRS
Observations by the Cores to Disk Legacy Team with the Spitzer Space
Telescope have identified a low luminosity, mid-infrared source within the
dense core, Lynds 1014, which was previously thought to harbor no internal
source. Followup near-infrared and submillimeter interferometric observations
have confirmed the protostellar nature of this source by detecting scattered
light from an outflow cavity and a weak molecular outflow. In this paper, we
report the detection of cm continuum emission with the VLA. The emission is
characterized by a quiescent, unresolved 90 uJy 6 cm source within 0.2" of the
Spitzer source. The spectral index of the quiescent component is between 6 cm and 3.6 cm. A factor of two increase in 6 cm
emission was detected during one epoch and circular polarization was marginally
detected at the level with Stokes {V/I} % . We have
searched for 22 GHz H2O maser emission toward L1014-IRS, but no masers were
detected during 7 epochs of observations between June 2004 and December 2006.
L1014-IRS appears to be a low-mass, accreting protostar which exhibits cm
emission from a thermal jet or a wind, with a variable non-thermal emission
component. The quiescent cm radio emission is noticeably above the correlation
of 3.6 cm and 6 cm luminosity versus bolometric luminosity, indicating more
radio emission than expected. We characterize the cm continuum emission in
terms of observations of other low-mass protostars, including updated
correlations of centimeter continuum emission with bolometric luminosity and
outflow force, and discuss the implications of recent larger distance estimates
on the physical attributes of the protostar and dense molecular core.Comment: 14 pages. Accepted for publication in Ap
Comparing variant calling algorithms for target-exon sequencing in a large sample
Abstract
Background
Sequencing studies of exonic regions aim to identify rare variants contributing to complex traits. With high coverage and large sample size, these studies tend to apply simple variant calling algorithms. However, coverage is often heterogeneous; sites with insufficient coverage may benefit from sophisticated calling algorithms used in low-coverage sequencing studies. We evaluate the potential benefits of different calling strategies by performing a comparative analysis of variant calling methods on exonic data from 202 genes sequenced at 24x in 7,842 individuals. We call variants using individual-based, population-based and linkage disequilibrium (LD)-aware methods with stringent quality control. We measure genotype accuracy by the concordance with on-target GWAS genotypes and between 80 pairs of sequencing replicates. We validate selected singleton variants using capillary sequencing.
Results
Using these calling methods, we detected over 27,500 variants at the targeted exons; >57% were singletons. The singletons identified by individual-based analyses were of the highest quality. However, individual-based analyses generated more missing genotypes (4.72%) than population-based (0.47%) and LD-aware (0.17%) analyses. Moreover, individual-based genotypes were the least concordant with array-based genotypes and replicates. Population-based genotypes were less concordant than genotypes from LD-aware analyses with extended haplotypes. We reanalyzed the same dataset with a second set of callers and showed again that the individual-based caller identified more high-quality singletons than the population-based caller. We also replicated this result in a second dataset of 57 genes sequenced at 127.5x in 3,124 individuals.
Conclusions
We recommend population-based analyses for high quality variant calls with few missing genotypes. With extended haplotypes, LD-aware methods generate the most accurate and complete genotypes. In addition, individual-based analyses should complement the above methods to obtain the most singleton variants.http://deepblue.lib.umich.edu/bitstream/2027.42/110906/1/12859_2015_Article_489.pd
Tracing the Mass during Low-Mass Star Formation. II. Modelling the Submillimeter Emission from Pre-Protostellar Cores
We have modeled the emission from dust in pre-protostellar cores, including a
self-consistent calculation of the temperature distribution for each input
density distribution. Model density distributions include Bonnor-Ebert spheres
and power laws. The Bonnor-Ebert spheres fit the data well for all three cores
we have modeled. The dust temperatures decline to very low values (\Td \sim 7
K) in the centers of these cores, strongly affecting the dust emission.
Compared to earlier models that assume constant dust temperatures, our models
indicate higher central densities and smaller regions of relatively constant
density. Indeed, for L1544, a power-law density distribution, similar to that
of a singular, isothermal sphere, cannot be ruled out. For the three sources
modeled herein, there seems to be a sequence of increasing central
condensation, from L1512 to L1689B to L1544. The two denser cores, L1689B and
L1544, have spectroscopic evidence for contraction, suggesting an evolutionary
sequence for pre-protostellar cores.Comment: 22 pages, 9 figures, Ap. J. accepted, uses emulateapj5.st
The Green Bank Ammonia Survey (GAS): First Results of NH3 mapping the Gould Belt
We present an overview of the first data release (DR1) and first-look science
from the Green Bank Ammonia Survey (GAS). GAS is a Large Program at the Green
Bank Telescope to map all Gould Belt star-forming regions with
mag visible from the northern hemisphere in emission from NH and other key
molecular tracers. This first release includes the data for four regions in
Gould Belt clouds: B18 in Taurus, NGC 1333 in Perseus, L1688 in Ophiuchus, and
Orion A North in Orion. We compare the NH emission to dust continuum
emission from Herschel, and find that the two tracers correspond closely.
NH is present in over 60\% of lines-of-sight with mag in
three of the four DR1 regions, in agreement with expectations from previous
observations. The sole exception is B18, where NH is detected toward ~ 40\%
of lines-of-sight with mag. Moreover, we find that the NH
emission is generally extended beyond the typical 0.1 pc length scales of dense
cores. We produce maps of the gas kinematics, temperature, and NH column
densities through forward modeling of the hyperfine structure of the NH
(1,1) and (2,2) lines. We show that the NH velocity dispersion,
, and gas kinetic temperature, , vary systematically between
the regions included in this release, with an increase in both the mean value
and spread of and with increasing star formation activity.
The data presented in this paper are publicly available.Comment: 33 pages, 27 figures, accepted to ApJS. Datasets are publicly
available: https://dataverse.harvard.edu/dataverse/GAS_DR
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