Development of Intelligent Interface to Input and Edit Meteorological Data

The paper presents the method of development of user interface for the hydrometeorological data acquisition system. This research includes some basic principles of creating hydrometeorological messages according to code KN-01 SYNOP. This code allows creating messages as a set of code groups. Every group keeps values of definite meteorological properties. The result of studies was implemented in creating of the user interface for the software that allows working with hydrometeorological data. The KN-01 code defines the class hierarchy of this software. The studies have shown that this method of software development is especially effective for visualization of the meteorological telegrams on devices with small display

Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis

© 2016, National Academy of Sciences. All rights reserved.Non-small cell lung cancer (NSCLC) has a 5-y survival rate of ∼16%, with most deaths associated with uncontrolled metastasis. We screened for stem cell identity-related genes preferentially expressed in a panel of cell lines with high versus low metastatic potential, derived from NSCLC tumors of KrasLA1/+;P53R172HΔG/+ (KP) mice. The Musashi-2 (MSI2) protein, a regulator of mRNA translation, was consistently elevated in metastasis-competent cell lines. MSI2 was overexpressed in 123 human NSCLC tumor specimens versus normal lung, whereas higher expression was associated with disease progression in an independent set of matched normal/primary tumor/lymph node specimens. Depletion of MSI2 in multiple independent metastatic murine and human NSCLC cell lines reduced invasion and metastatic potential, independent of an effect on proliferation. MSI2 depletion significantly induced expression of proteins associated with epithelial identity, including tight junction proteins [claudin 3 (CLDN3), claudin 5 (CLDN5), and claudin 7 (CLDN7)] and down-regulated direct translational targets associated with epithelial-mesenchymal transition, including the TGF-β receptor 1 (TGFβR1), the small mothers against decapentaplegic homolog 3 (SMAD3), and the zinc finger proteins SNAI1 (SNAIL) and SNAI2 (SLUG). Overexpression of TGFβRI reversed the loss of invasion associated with MSI2 depletion, whereas overexpression of CLDN7 inhibited MSI2-dependent invasion. Unexpectedly, MSI2 depletion reduced E-cadherin expression, reflecting a mixed epithelial-mesenchymal phenotype. Based on this work, we propose that MSI2 provides essential support for TGFβR1/SMAD3 signaling and contributes to invasive adenocarcinoma of the lung and may serve as a predictive biomarker of NSCLC aggressiveness

Understanding How Microplastics Affect Marine Biota on the Cellular Level Is Important for Assessing Ecosystem Function: A Review

Plastic has become indispensable for human life. When plastic debris is discarded into waterways, these items can interact with organisms. Of particular concern are microscopic plastic particles (microplastics) which are subject to ingestion by several taxa. This review summarizes the results of cutting-edge research about the interactions between a range of aquatic species and microplastics, including effects on biota physiology and secondary ingestion. Uptake pathways via digestive or ventilatory systems are discussed, including (1) the physical penetration of microplastic particles into cellular structures, (2) leaching of chemical additives or adsorbed persistent organic pollutants (POPs), and (3) consequences of bacterial or viral microbiota contamination associated with microplastic ingestion. Following uptake, a number of individual-level effects have been observed, including reduction of feeding activities, reduced growth and reproduction through cellular modifications, and oxidative stress. Microplastic-associated effects on marine biota have become increasingly investigated with growing concerns regarding human health through trophic transfer. We argue that research on the cellular interactions with microplastics provide an understanding of their impact to the organisms’ fitness and, therefore, its ability to sustain their functional role in the ecosystem. The review summarizes information from 236 scientific publications. Of those, only 4.6% extrapolate their research of microplastic intake on individual species to the impact on ecosystem functioning. We emphasize the need for risk evaluation from organismal effects to an ecosystem level to effectively evaluate the effect of microplastic pollution on marine environments. Further studies are encouraged to investigate sublethal effects in the context of environmentally relevant microplastic pollution conditions

Heat-treatment effect on the structural and optical properties of flash evaporated Sb 2

The effect of thickness and heat treatment on the structural and optical properties of Sb2Te3 thin films fabricated by using flash evaporation technique were investigated. The as-deposited films were found to be stoichiometric. For the as-deposited and annealed samples of thickness in the range of 20.7–120.5 nm, large variations in transmittance and reflectance were observed for wavelength below 2000 nm due to strong absorption, while slight variations were observed above 2000 nm. The optical constants, n and k, measured in the range of 500–4000 nm, increased slightly by annealing the samples at 573 K for 2 h in air and a red shift was observed. Allowed indirect transitions were observed for the as-deposited and the annealed samples. The results showed two energy gaps for these transitions varied from 0.28 to 0.31 eV for the as-deposited samples and from 0.56 to 0.54 eV for the annealed films. The spectral distribution of the real part of the dielectric constant ε′ showed a maximum at 0.73 eV for the as-deposited films decreased to 0.65 eV by annealing