Direct Detection is testing Freeze-in

Dark Matter (DM) may belong to a hidden sector that is only feebly interacting with the Standard Model (SM) and may have never been in thermal equilibrium in the Early Universe. In this case, the observed abundance of dark matter particles could have built up through a process known as Freeze-in. We show that, for the first time, direct detection experiments are testing this DM production mechanism. This applies to scenarios where the SM and hidden sectors communicate through a light mediator particle of mass less than a few MeV. Through the exchange of such light mediator, the very same FIMP candidates can have self-interactions that are in the range required to address the small scale structure issues of collisionless cold dark matter.Comment: 7 pages, 4 figures. References added. Discussion of further constraints on parameters. Figures updated. Conclusions unchanged. Matches published versio

Top-philic Vector-Like Portal to Scalar Dark Matter

We investigate the phenomenology of scalar singlet dark matter candidates that couple dominantly to the Standard Model via a Yukawa interaction with the top quark and a colored vector-like fermion. We estimate the viability of this vector-like portal scenario with respect to the most recent bounds from dark matter direct and indirect detection, as well as to dark matter and vector-like mediator searches at colliders. Moreover, we take QCD radiative corrections into account in all our theoretical calculations. This work complements analyses related both to models featuring a scalar singlet coupled through a vector-like portal to light quarks, and to scenarios in which the dark matter is a Majorana singlet coupled to the Standard Model through scalar colored particles (akin to simplified models inspired by supersymmetry). Our study puts especially forward the complementarity of different search strategies from different contexts, and we show that current experiments allow for testing dark matter masses ranging up to 700 GeV and mediator masses ranging up to 6 TeV.Comment: 15 pages, 11 figures; version accepted by PR

Radiative corrections to vectorlike portal dark matter

A massive real scalar dark matter particle $S$ can couple to Standard Model leptons or quarks through a vector-like fermionic mediator $\psi$, a scenario known as the Vector-like portal. Due to helicity suppression of the annihilation cross section into a pair of SM fermions, it has been shown in previous works that radiative corrections, either at one-loop or through radiation of gauge bosons, may play a significant role both in determining the relic abundance and for indirect detection. All previous works considered the limit of massless final state quarks or leptons. In this work, we focus on a technical issue, which is to reliably determine the annihilation cross sections taking into account finite fermion masses. Following previous works in the framework of simplified supersymmetric dark matter scenarios, and building on an analogy with Higgs decay into fermions, we address the issue of infrared and collinear divergences that plagues the cross section by adopting an effective operator description, which captures most of the relevant physics and give explicit expressions for the annihilation cross sections. We then develop several approximations for the differential and total cross sections, which simplify greatly their expressions, and which can then be used in various phenomenological studies of similar models. Finally, we describe our method to compute the final gamma-ray spectrum, including hadronisation of the heavy fermions, and provide some illustrative spectra for specific dark matter candidates.Comment: 25 pages, 12 figures. One extra figure. Conclusions unchanged. Version published in PR

Gentlest ascent dynamics on manifolds defined by adaptively sampled point-clouds

Finding saddle points of dynamical systems is an important problem in practical applications such as the study of rare events of molecular systems. Gentlest ascent dynamics (GAD) is one of a number of algorithms in existence that attempt to find saddle points in dynamical systems. It works by deriving a new dynamical system in which saddle points of the original system become stable equilibria. GAD has been recently generalized to the study of dynamical systems on manifolds (differential algebraic equations) described by equality constraints and given in an extrinsic formulation. In this paper, we present an extension of GAD to manifolds defined by point-clouds, formulated using the intrinsic viewpoint. These point-clouds are adaptively sampled during an iterative process that drives the system from the initial conformation (typically in the neighborhood of a stable equilibrium) to a saddle point. Our method requires the reactant (initial conformation), does not require the explicit constraint equations to be specified, and is purely data-driven

Improving the Efficiency of Inductive Logic Programming Through the Use of Query Packs

Inductive logic programming, or relational learning, is a powerful paradigm for machine learning or data mining. However, in order for ILP to become practically useful, the efficiency of ILP systems must improve substantially. To this end, the notion of a query pack is introduced: it structures sets of similar queries. Furthermore, a mechanism is described for executing such query packs. A complexity analysis shows that considerable efficiency improvements can be achieved through the use of this query pack execution mechanism. This claim is supported by empirical results obtained by incorporating support for query pack execution in two existing learning systems

Interventricular Differences in β‐Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases

Background RV and LV have different embryologic, structural, metabolic, and electrophysiologic characteristics, but whether interventricular differences exist in β‐adrenergic (β‐AR) responsiveness is unknown. In this study, we examine whether β‐AR response and signaling differ in right (RV) versus left (LV) ventricles. Methods and Results Sarcomere shortening, Ca2+ transients, ICa,L and IKs currents were recorded in isolated dog LV and RV midmyocytes. Intracellular [cAMP] and PKA activity were measured by live cell imaging using FRET‐based sensors. Isoproterenol increased sarcomere shortening ≈10‐fold and Ca2+‐transient amplitude ≈2‐fold in LV midmyocytes (LVMs) versus ≈25‐fold and ≈3‐fold in RVMs. FRET imaging using targeted Epac2camps sensors revealed no change in subsarcolemmal [cAMP], but a 2‐fold higher β‐AR stimulation of cytoplasmic [cAMP] in RVMs versus LVMs. Accordingly, β‐AR regulation of ICa,L and IKs were similar between LVMs and RVMs, whereas cytoplasmic PKA activity was increased in RVMs. Both PDE3 and PDE4 contributed to the β‐AR regulation of cytoplasmic [cAMP], and the difference between LVMs and RVMs was abolished by PDE3 inhibition and attenuated by PDE4 inhibition. Finally LV and RV intracavitary pressures were recorded in anesthetized beagle dogs. A bolus injection of isoproterenol increased RV dP/dtmax≈5‐fold versus 3‐fold in LV. Conclusion Canine RV and LV differ in their β‐AR response due to intrinsic differences in myocyte β‐AR downstream signaling. Enhanced β‐AR responsiveness of the RV results from higher cAMP elevation in the cytoplasm, due to a decreased degradation by PDE3 and PDE4 in the RV compared to the LV