340 research outputs found
Recommended from our members
Microconfined flow behavior of red blood cells by image analysis techniques
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.Red blood cells (RBCs) perform essential functions in human body, such as gas exchange between
blood and tissues, thanks to their ability to deform and flow in the microvascular network. The high RBC
deformability is mainly due to the viscoelastic properties of the cell membrane. Since an impaired RBC
deformability could be found in some diseases, such as malaria, sickle cell anemia, diabetes and hereditary
disorders, there is the need to provide further insight into measurement of RBC deformability in a
physiologically-relevant flow field. Here, we report on an imaging-based in vitro systematic microfluidic
investigation of RBCs flowing either in microcapillaries or in a microcirculation-mimicking device
containing a network of microchannels of diameter comparable to cell size. RBC membrane shear elastic
modulus and surface viscosity have been investigated by using diverging channels, while RBC time recovery
constant have been measured in start-up experiments. Moreover, RBC volume and surface area have been
measured in microcapillary flow. The comprehension of the single cell behavior led to the analysis of the
RBC flow-induced clustering. Overall, our results provide a novel technique to estimate RBC deformability,
that can be used for the analysis of pathological RBCs, for which reliable quantitative methods are still
lacking
Three-systems for visual numerosity: A single case study
Abstract Humans possess the remarkable capacity to assess the numerosity of a set of items over a wide range of conditions, from a handful of items to hundreds of them. Recent evidence is starting to show that judgments over such a large range is possible because of the presence of three mechanisms, each tailored to specific stimulation conditions. Previous evidence in favour of this theory comes from the fact that discrimination thresholds and estimation reaction times are not constants across numerosity levels. Likewise, attention is capable of dissociating the three mechanisms: when healthy adult observers are asked to perform concurrently a taxing task, the judgments of low numerosities
Voice assistants in hospital triage operations
This paper analyzes the creation and usage of a voice assistant for the triage of emergency room patients. This human-centred intelligent system strongly relies on Mycroft, an extensible open source voice assistant. The patients are able to declare their symptoms to the agent, which recognizes the urgency and acts accordingly. The software can even provide useful medical informations to the users
Recommended from our members
Microfluidic mixing of low viscosity Boger fluids
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.This study is focused on the development of low viscosity Boger fluids and on the investigation of their elasticity on emulsion formation. Non-Newtonian continuous phases (Boger fluids) made of two different molecular weight Polyacrylamide in water plus glycerol solutions were used. While, as Newtonian continuous phase, a water plus glycerol solution showing the same viscosity as the non-Newtonian one was prepared and as dispersed phase silicon oil was used. Visualization of these emulsions flowing through a micromixer was useful in order to extract quantitative informations of their behavior, such as the velocity profile and droplets’ size distribution. Then the formation of vortex upstream of a divergent-convergent configuration has been shown as the wall migration effect, which drives droplets away from the walls and toward the center of the microcapillary investigated
Emotion-based analysis of programming languages on Stack Overflow
When developing a software engineering project, selecting the most appropriate programming language is a crucial step. Most often, feeling at ease with the possible options becomes almost as relevant as the technical features of the language. Therefore, it appears to be worth analyzing the role that the emotional component plays in this process. In this article, we analyze the trend of the emotions expressed by developers in 2018 on the Stack Overflow platform in posts concerning 26 programming languages. To do so, we propose a learning model trained by distant supervision and the comparison of two different classifier architectures
"bisphenol a: An emerging threat to male fertility"
Background: Among the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive science community, due to its ubiquitous presence in day-to-day life. Its toxic action appears to mainly affect the male reproductive system, directly impacting male fertility. Main: The purpose of this review is to investigate current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action. Conclusion: A clear understanding of BPA action mechanisms, as well as the presumed risks deriving from its exposure, is becoming crucial to preserve male fertility. The development and validation of methodologies to detect BPA toxic effects on reproductive organs can provide greater awareness of the potential threat that this chemical represents
Recommended from our members
Microfluidic interactions between red blood cells and drug carriers by image analysis techniques
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.Blood is a complex biological fluid composed of deformable cells and platelets suspended in
plasma, a protein-rich liquid. The peculiar nature of blood needs to be considered when designing a drug
delivery strategy based on systemically administered carriers. Here, we report on an in vitro fluid dynamic
investigation of the influence of the microcapillary flow of red blood cells (RBCs) on micron sized carriers
by high speed imaging methods. The experiments were carried out in a 50ÎĽm diameter glass capillary that
mimicked the hydrodynamic conditions of human microcirculation. Spherical ÎĽ particles (ÎĽ-Ps), with sizes
ranging between 0.5 and 3ÎĽm, were tested. Images of the flowing RBCs and ÎĽ-Ps were acquired by a highspeed/ high-magnification microscopy. The transport and distribution of rigid particles in a suspension of
RBCs under shear flow were followed for: i) the migration of RBCs towards the vessel centerline due to
their deformability; ii) the cross-flow migration of ÎĽ-Ps towards the vessel wall due to their hydrodynamic
interactions with RBCs; iii) the radial distribution of ÎĽ-Ps in the presence of RBCs. This study suggests that
the therapeutic efficacy of ÎĽ-Ps could be ultimately affected by their interactions with the flowing RBCs in
the vasculature
Mobility in Unsupervised Word Embeddings for Knowledge Extraction—The Scholars’ Trajectories across Research Topics
In the knowledge discovery field of the Big Data domain the analysis of geographic positioning and mobility information plays a key role. At the same time, in the Natural Language Processing (NLP) domain pre-trained models such as BERT and word embedding algorithms such as Word2Vec enabled a rich encoding of words that allows mapping textual data into points of an arbitrary multi-dimensional space, in which the notion of proximity reflects an association among terms or topics. The main contribution of this paper is to show how analytical tools, traditionally adopted to deal with geographic data to measure the mobility of an agent in a time interval, can also be effectively applied to extract knowledge in a semantic realm, such as a semantic space of words and topics, looking for latent trajectories that can benefit the properties of neural network latent representations. As a case study, the Scopus database was queried about works of highly cited researchers in recent years. On this basis, we performed a dynamic analysis, for measuring the Radius of Gyration as an index of the mobility of researchers across scientific topics. The semantic space is built from the automatic analysis of the paper abstracts of each author. In particular, we evaluated two different methodologies to build the semantic space and we found that Word2Vec embeddings perform better than the BERT ones for this task. Finally, The scholars’ trajectories show some latent properties of this model, which also represent new scientific contributions of this work. These properties include (i) the correlation between the scientific mobility and the achievement of scientific results, measured through the H-index; (ii) differences in the behavior of researchers working in different countries and subjects; and (iii) some interesting similarities between mobility patterns in this semantic realm and those typically observed in the case of human mobility
- …