Perbedaan Kadar Gula Darah Antara Anak SD Dengan Obesitas Dan Tidak Obesitas Padasiswa SD Di Kota Manado

: Obesity is a condition in which excess body fat accumulation, so that one\u27s weight is well above normal and can endanger the health of overweight and obesity in children may lead to diabetes or type 2 diabetes known as a disease characterized by the inability of insulin to control sugar levels dara within the normal range study aimed to determine differences in blood sugar levels among elementary school children dengaan obesity and obesity in elementary school children in the city of Manado with analytic survey research design using a cross sectional design. 136 samples using t-test, at the 95% significance level (α 0,05). The results there are different levels of blood sugar and obesity among elementary school children are not obese in Manado City For readers advice that can be references for the development of materials keperawatan.Bagi adolescents to pay attention to diet seta healthy foods that can prevent, increase sugar levels blood as early as possible For further research in order to examine the levels of LDL cholesterol, HDL and fasting blood sugar levels (GDP) as well as other factors that can affect blood sugar levels in childre

Attenuated variants of Lesch-Nyhan disease

Lesch–Nyhan disease is a neurogenetic disorder caused by deficiency of the enzyme hypoxanthine–guanine phosphoribosyltransferase. The classic form of the disease is described by a characteristic syndrome that includes overproduction of uric acid, severe generalized dystonia, cognitive disability and self-injurious behaviour. In addition to the classic disease, variant forms of the disease occur wherein some clinical features are absent or unusually mild. The current studies provide the results of a prospective and multi-centre international study focusing on neurological manifestations of the largest cohort of Lesch–Nyhan disease variants evaluated to date, with 46 patients from 3 to 65 years of age coming from 34 families. All had evidence for overproduction of uric acid. Motor abnormalities were evident in 42 (91%), ranging from subtle clumsiness to severely disabling generalized dystonia. Cognitive function was affected in 31 (67%) but it was never severe. Though none exhibited self-injurious behaviours, many exhibited behaviours that were maladaptive. Only three patients had no evidence of neurological dysfunction. Our results were compared with a comprehensive review of 78 prior reports describing a total of 127 Lesch–Nyhan disease variants. Together these results define the spectrum of clinical features associated with hypoxanthine–guanine phosphoribosyltransferase deficiency. At one end of the spectrum are patients with classic Lesch–Nyhan disease and the full clinical phenotype. At the other end of the spectrum are patients with overproduction of uric acid but no apparent neurological or behavioural deficits. Inbetween are patients with varying degrees of motor, cognitive, or behavioural abnormalities. Recognition of this spectrum is valuable for understanding the pathogenesis and diagnosis of all forms of hypoxanthine–guanine phosphoribosyltransferase deficiency