Models of Collapsing and Expanding Anisotropic Gravitating Source in f(R,T)f(R,T) Theory of Gravity

In this paper, we have formulated the exact solutions of the non-static anisotropic gravitating source in $f(R,T)$ gravity which may lead to expansion and collapse. By assuming the no thermal conduction in gravitating source, we have determine parametric solutions in $f(R,T)$ gravity with non-static spherical geometry filled with anisotropic fluid. We have examined the range of parameter for which expansion scalar become negative and positive leading to collapse and expansion, respectively. Further, using the definition of mass function the condition for the trapped surface have been explored and it has been investigated there exists a single horizon in this case. The impact of coupling parameter $\lambda$ has been discussed in detail in both cases. For the various values of coupling parameter $\lambda$, we have plotted energy density, anisotropic pressure and anisotropic parameter in case of collapse and expansion. The physical significance of the graphs has been explained in detail.Comment: 18 Pages, 8 Figures, Accepted for Publication in European Physical Journal

Episodic accretion in binary protostars emerging from self-gravitating solar mass cores

Observations show a large spread in the luminosities of young protostars, which are frequently explained in the context of episodic accretion. We here test this scenario using numerical simulations following the collapse of a solar mass molecular cloud using the GRADSPH code, varying the strength of the initial perturbations and the temperature of the cores. A specific emphasis of this paper is to investigate the role of binaries and multiple systems in the context of episodic accretion, and to compare their evolution to the evolution in isolated fragments. Our models form a variety of low mass protostellar objects including single, binary and triple systems with binaries more active in exhibiting episodic accretion than isolated protostars. We also find a general decreasing trend for the average mass accretion rate over time, suggesting that the majority of the protostellar mass is accreted within the first 10^5 years. This result can potentially help to explain the surprisingly low average luminosities in the majority of the protostellar population.Comment: 16 pages, 13 figures, 4 tables. Accepted for publication with A&

Revised analysis of SPIRE observations for 2M1207

We have revised our analysis of the SPIRE observations of 2MASSW J1207334-393254 (2M1207). Recent PACS observations show a bright source located ~25" east of 2M1207. There are issues in terms of the detection/non-detection of the bright source when comparing the Spitzer, WISE, and PACS observations. It is apparently inconsistent, perhaps due to variability or low signal-to-noise of the data. We have looked into the possible misidentification of the target, and have revised the measured SPIRE fluxes and the disc parameters for 2M1207. We have also reviewed which among the various formation mechanisms of this system would still be valid.Comment: Revised SPIRE fluxe

Evidence Reversal: An exploratory analysis of randomized controlled trials from the New England Journal of Medicine

BACKGROUND: Evidence Reversal (ER) is the phenomenon whereby new and stronger evidence contradicts previously established evidence. OBJECTIVES: To quantify evidence reversals and to determine characteristics associated with reversibility. METHODS: Original articles from the New England Journal of Medicine (2000 to 2016) were screened for three inclusion criteria: tested a clinical practice; Randomized Controlled Trial design; and tested an established clinical practice. The proportion of RCTs that represented ER was determined. Association of trial characteristics with reversal was explored using logistic regression in order to inform a potential framework of reversibility. RESULTS: In total, 611 RCTs met the inclusion criteria, of which 54% were evidence reversals. Based on variables associated with ER, a reversibility framework was proposed, comprised of eight trial characteristics. CONCLUSION: More than 50% of RCTs published in the NEJM that test established practices are evidence reversals. The characteristics of RCTs that are associated with reversal will inform future research to further understand reversibility

A near-infrared variability campaign of TMR-1: New light on the nature of the candidate protoplanet TMR-1C

(abridged) We present a near-infrared (NIR) photometric variability study of the candidate protoplanet, TMR-1C, located at a separation of about 10" (~1000 AU) from the Class I protobinary TMR-1AB in the Taurus molecular cloud. Our campaign was conducted between October, 2011, and January, 2012. We were able to obtain 44 epochs of observations in each of the H and Ks filters. Based on the final accuracy of our observations, we do not find any strong evidence of short-term NIR variability at amplitudes of >0.15-0.2 mag for TMR-1C or TMR-1AB. Our present observations, however, have reconfirmed the large-amplitude long-term variations in the NIR emission for TMR-1C, which were earlier observed between 1998 and 2002, and have also shown that no particular correlation exists between the brightness and the color changes. TMR-1C became brighter in the H-band by ~1.8 mag between 1998 and 2002, and then fainter again by ~0.7 mag between 2002 and 2011. In contrast, it has persistently become brighter in the Ks-band in the period between 1998 and 2011. The (H-Ks) color for TMR-1C shows large variations, from a red value of 1.3+/-0.07 and 1.6+/-0.05 mag in 1998 and 2000, to a much bluer color of -0.1+/-0.5 mag in 2002, and then again a red color of 1.1+/-0.08 mag in 2011. The observed variability from 1998 to 2011 suggests that TMR-1C becomes fainter when it gets redder, as expected from variable extinction, while the brightening observed in the Ks-band could be due to physical variations in its inner disk structure. The NIR colors for TMR-1C obtained using the high precision photometry from 1998, 2000, and 2011 observations are similar to the protostars in Taurus, suggesting that it could be a faint dusty Class I source. Our study has also revealed two new variable sources in the vicinity of TMR-1AB, which show long-term variations of ~1-2 mag in the NIR colors between 2002 and 2011.Comment: Accepted in A&

Toxicity induced by Solanapyrone A in Chickpea shoots and its metabolism through Glutathione/Glutathione-S-Transferase system

Solanapyrone A and C were isolated from a Pakistani isolate of Ascochyta rabiei, Pk-1. Two experiments were conducted to investigate the phytotoxic effects of the most potent toxin, solanapyrone A on chickpea cultivars and its subsequent detoxification through glutathion/glutathion-s-transferase(GST) system. When the shoots of cultivars were fed solanapyrone A, symptoms mimicking to Ascochyta blight appeared and extent of manifestation of symptoms varied with the cultivar. In the first experiment, the effect of three different plant ages of 2 cultivars with different levels of resistance to toxin was determined in terms of GST activity unit. GST activity in Balkasar-2000 (a resistant cultivar) increased 1.92 times, 1.72 and 1.65 times in two-week-old seedling, eight-week-old and adult plants (all treated) respectively as compared to their respective controls. In the highly susceptible cultivar, AUG-424, a slight increase (1.14 times) over control was noticed in GST activity at all the three ages. In the second experiment, where shoots of three cultivars were tested against 2 doses of the toxin, an increase in GST activity in Noor-91 (a moderately susceptible cultivar) and AUG-424 was significantly less than resistant cultivar, Balkasar-2000 showing direct relationship between resistance and activity of the enzyme. It may be concluded that it is a reason for difference in response of cultivars to the disease

A Non-Functional Carbon Dioxide-Mediated Post-Translational Modification on Nucleoside Diphosphate Kinase of Arabidopsis thaliana

The carbamate post-translational modification (PTM), formed by the nucleophilic attack of carbon dioxide by a dissociated lysine epsilon-amino group, is proposed as a widespread mechanism for sensing this biologically important bioactive gas. Here, we demonstrate the discovery and in vitro characterization of a carbamate PTM on K9 of Arabidopsis nucleoside diphosphate kinase (AtNDK1). We demonstrate that altered side chain reactivity at K9 is deleterious for AtNDK1 structure and catalytic function, but that CO2 does not impact catalysis. We show that nucleotide substrate removes CO2 from AtNDK1, and the carbamate PTM is functionless within the detection limits of our experiments. The AtNDK1 K9 PTM is the first demonstration of a functionless carbamate. In light of this finding, we speculate that non-functionality is a possible feature of the many newly identified carbamate PTMs