8,641 research outputs found
Satellite personal communications system
Voice channel communication between low power mobile stations dispersed over a large area is provided by a system which includes a geostationary satellite utilizing a large UHF antenna that can receive a transmission from a caller and retransmit it over any one beam of a matrix of narrow beams, so the chosen beam covers an area in which a designated called party is located. A single up-link control channel occupying a narrow frequency band, can be utilized to receive dial up signals from a caller, and another single down link control channel can be utilized to ring up the called party located anywhere within the continental United States. The satellite antenna includes a matrix of feed horns that not only direct the beams in a controlled matrix onto the area of the continental United States, but also permit detection of the region from which the caller's signal is transmitted and the region from which the called party's answer is received, to enable the interconnection of signals received from these two regions. The system is particularly useful for rural areas
Changes in monetary policy and the variation in interest rate changes across credit markets
This article uses principal component methods to assess the importance of changes in the federal funds rate in driving interest rate changes across a broad array of credit markets. We find that most of the variability in interest rate changes across these markets is explained by a small number of common components. Furthermore, for many of the interest rate series in our sample, changes that reflect common movements are highly correlated with changes in the federal funds rate. However, in some credit markets associated with longer maturities, such as the mortgage market, common movements are less correlated with changes in the federal funds rate. Therefore, interest rate changes in those markets are i) more likely to reflect aggregate disturbances somewhat unrelated to monetary policy, or ii) related to contemporaneous monetary policy more indirectly through changes in expected future short rates. We also find evidence that movements in the auto loan market are almost entirely driven by idiosyncratic considerations rather than changes in the federal funds rate.Inflation (Finance) ; Monetary policy ; Financial markets
Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes
Background
During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase. This expression is stimulated by inducers including BMPs and ascorbate. A 316 base pair region of the type X collagen (Col X) promoter has been previously characterized as the site required for BMP regulation. The intent of this study was to examine the role of Mitogen Activated Protein (MAP) and related kinase pathways in the regulation of Col X transcription and alkaline phosphatase activity in pre-hypertrophic chick chondrocytes.
Results
Using a luciferase reporter regulated by the BMP-responsive region of the type X collagen promoter, we show that promoter activity is increased by inhibition of extra-cellular signal regulated kinases 1 or 2 (ERK1/2). In contrast the ability of BMP-2 to induce alkaline phosphatase activity is little affected by ERK1/2 inhibition. The previously demonstrated stimulatory affect of p38 on Col X was shown to act specifically at the BMP responsive region of the promoter. The inhibitory effect of the ERK1/2 pathway and stimulatory effect of the p38 pathway on the Col X promoter were confirmed by the use of mutant kinases. Inhibition of upstream kinases: protein kinase C (PKC) and phosphatidylinositol 3-(PI3) kinase pathways increased basal Col X activity but had no effect on the BMP-2 induced increase. In contrast, ascorbate had no effect on the BMP-2 responsive region of the Col X promoter nor did it alter the increase in promoter activity induced by ERK1/2 inhibition. The previously shown increase in alkaline phosphatase activity induced by ascorbate was not affected by any kinase inhibitors examined. However some reduction in the alkaline phosphatase activity induced by the combination of BMP-2 and ascorbate was observed with ERK1/2 inhibition.
Conclusion
Our results demonstrate that ERK1/2 plays a negative role while p38 plays a positive role in the BMP-2 activated transcription of type X collagen. This regulation occurs specifically at the BMP-2 responsive promoter region of Col X. Ascorbate does not modulate Col X at this region indicating that BMP-2 and ascorbate exert their action on chondrocyte hypertrophy via different transcriptional pathways. MAP kinases seem to have only a modest effect on alkaline phosphatase when activity is induced by the combination of both BMP-2 and ascorbate
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Unlocking the Secrets of Ancient Writing. The Parallel Lives of Michael Ventris and Linda Schele and the Decipherment of Mycenaean and Mayan Writing
Catalogue of an exhibition conducted in conjunction with the Eleventh International Mycenological Colloquium held at the University of Texas at Austin in 2000. This program features brief histories of the CIPEM Mycenological conferences and PASP, followed by comparative retrospectives on both Michael Ventris, who deciphered Linear B, and Linda Schele, who performed a similar feat for Mayan glyphs.Classic
A survey of thermodynamic properties of the compounds of the elements CHNOPS Progress report, 1 Oct. - 31 Dec. 1966
Thermodynamic properties for compounds of the elements carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfu
Trauma-informed resilient child welfare agencies: A New England Learning Community — Summary of the work: April 2017
Are you serious? From fist bumping to hand hygiene: considering culture, context and complexity in infection prevention intervention research
Infection prevention is an under-resourced research and development topic, with limited evidence for practice in the most basic of measures. A survey of IPS R&D members indicated that what might appear to be simple interactions and interventions in healthcare, such as hand shaking and hand hygiene, should be considered complex interventions taking account of behaviour at the individual and social level as well as contextual factors. Future studies need to be designed utilising comprehensive approaches, for example, the Medical Research Council complex interventions framework, tailored to the country and more local cultural context, if we are to be serious about evidence for infection prevention and control practice
A survey of thermodynamic properties of the compounds of the element CHNOPS Progress report, 1 Mar. - 30 Jun. 1968
Thermodynamic property data tables for CHNOPS compounds and heats of combustion and formation for organic compounds of biological interes
Thermal behavior of the STM tip under laser irradiation
This thesis discusses the thermal behavior of the STM tip under laser irradiation. The thermal expansion of the tip was researched with varying laser spot size, frequency, location, and power. In order to determine the thermal expansion of the STM tip, the behavior in both the time and frequency domain were investigated. By employing the FFT analysis, the noise of the thermal behavior in the frequency domain was greatly reduced when compared to the time domain behavior, allowing for higher resolution expansions. With noise reduced, a thermal expansion of 1 nm, equating to a 0.03 K average temperature rise across the tip was found. Besides the heating and expansion of the STM tip, the thermal diffusivity of the PtIr STM tip was calculated using the TET and Characteristic Point methods, and found to be within 3% of the expected value
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