Automated Modeling of Real-Time Anomaly Detection using Non-Parametric Statistical technique for Data Streams in Cloud Environments

The main objective of online anomaly detection is to identify abnormal/unusual behavior such as network intrusions, malware infections, over utilized system resources due to design defects etc from real time data stream. Terrabytes of performance data generated in cloud data centers is a well accepted example of such data stream in real time. In this paper, we propose an online anomaly detection framework using non-parametric statistical technique in cloud data center. In order to determine the accuracy of the proposed work, we experiments it to data collected from RUBis cloud testbed and Yahoo Cloud Serving Benchmark (YCSB). Our experimental results shows the greater accuracy in terms of True Positive Rate (TPR), False Positive Rate (FPR), True Negative Rate (TNR) and False Negative Rate (FNR)

Calcibiocavitological investigations

Calcibiocavitation is a major poroblem in the marine environment and a detailed study on these aspects has been undertaken and the salient findings are presented here. Gregarious molluscs such as the sacred chank Xancus pvrum, mussels (both green and brown), rock oysters (Crassostrea spp.), pearl oysters, Thais rudolphi (Lam.) and corals which inhabit the southwest coast of Kerala and the Gulf of Mannar have been investigated. The wide fluctuations noted in the abundance and population structure of the various pests in the molluscan beds during the short period of two years clearly indicated that they were in severe competetion for suitable substrata and the shells of gregarious mollusks which inhabit this area provide ample opportunities for the pests to flourish. The incidence of boring sponges is found to be rather high among raft-cultured pearl oysters both at Tuticorin and Vizhinjam. It is difficult to control the infection of boring animals in the natural beds, but the low rate of incidence recorded year after year under suggests that the nature controls this to lower level.Another important observation was the wide distribution of the boring sponge C.vastifica in the Ashtamudi Lake, Quilonwhich may form a major threat to our future rock oyster farms along the estuaries

Modeling of a Cable-Based Revolute Joint Using Biphasic Media Variable Stiffness Actuation

In recent times, safe interactions between humans and robots are required for innumerable tasks and environments. This safety can be achieved using compliance design and control of mechanisms. Cable-driven mechanisms are used when applications need to have light structures, meaning that their actuators must be relocated to ground and forces are transferred along tensioned cables. This paper presents a compliant cable-driven revolute joint using biphasic media variable stiffness actuators. Actuator's stiffness is controlled by changing pressure of control fluid into distribution lines. The used control fluid is biphasic, composed of separated gas and liquid fractions with predefined ratio. The mathematical model of the actuator is presented along with its position and stiffness model-based control, then, equations relating to the dynamics of the mechanism are provided with a joint stiffness and orientation controller. Results from simulations are discussed

Invasion of Cliona margaritifera Dendy and C.lobata Hancock on the molluscan beds along the Indian coast

In the recent past the invasion of two new sponge pests Cliona margaritifera Dendy and C. lobata Hancock on the molluscan beds of the southwest coast of India is reported. These two new pests made their first appearance on cultured pearl oysters on raft at Vizhinjam in 1980 and thence started spreading to the economically important molluscan beds in and around Vizhinjam. The spreading of these pests along the southwest coast of India was rather fast and from this coast C. margaritifera could migrate to the raft-cultured pear! oysters at Tuticorin and C. lobata to the chank beds off Tbiruchendur (southeast coast) within two years i.e. by 1982

Observations on the early juvenile stages of Johnius carutta Bloch, Pervager tomentosus (Linnaeus) and on a post larva of Pegasus volitans Linnaeus

Observations made on the early juvenile stages of a sciaenid, Johnius carutta Bloch and a file-fish assigned to Pervager tomentosus (Linnaeus) are described. A brief account on a single postlarva of Pegasus volitans Linnaeus measuring 6 mm is also included due to the nature of its abnormal pigmentation

Abel-Jacobi maps for hypersurfaces and non commutative Calabi-Yau's

It is well known that the Fano scheme of lines on a cubic 4-fold is a symplectic variety. We generalize this fact by constructing a closed p-form with p=2n-4 on the Fano scheme of lines on a (2n-2)-dimensional hypersurface Y of degree n. We provide several definitions of this form - via the Abel-Jacobi map, via Hochschild homology, and via the linkage class, and compute it explicitly for n = 4. In the special case of a Pfaffian hypersurface Y we show that the Fano scheme is birational to a certain moduli space of sheaves on a p-dimensional Calabi--Yau variety X arising naturally in the context of homological projective duality, and that the constructed form is induced by the holomorphic volume form on X. This remains true for a general non Pfaffian hypersurface but the dual Calabi-Yau becomes non commutative.Comment: 34 pages; exposition of Hochschild homology expanded; references added; introduction re-written; some imrecisions, typos and the orbit diagram in the last section correcte

Oceanic squids - their distribution, abundance and potential in the EEZ of India and contiguous seas

FORV Sagar Sampada collected a good number of oceanic squids belonging to several families from the Indian EEZ and contiguous seas. Of these, the most important species was the purpleback flying squid Symplectoteuthis oualaniensis which forms a potential oceanic squid resource. This species was caught in pelagic trawl at depths up to.200-250 m from surface in the oceanic areas. Though the squid is known to be distributed throughout India's oceanic waters, it frequently occurred in comparatively more abundance, up to 318 squids per haul, in the northneastem Arabian Sea. There was wide variation in the size of this squid (from 20 mm to 472 mm), the largest individual weighing 4.5 kg. The diamondback squid Thysanoteuthis rhombus, the largest specimen of which measured 585 mm in length and 5.3 kg in weight, was also caught from a few stations. Besides these large species, several others belonging to families such as Onychoteuthidae, Histioteuthidae, Enoploteuthidae and Cranchiidae are also distributed in the EEZ. A large number of oceanic squids were collected at night, which is indicative of their diel vertical migration towards surface layers during night hours

Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants

Infant mortality from dengue disease is a devastating global health burden that could be minimized with the ability to identify susceptibility for severe disease prior to infection. Although most primary infant dengue infections are asymptomatic, maternally derived anti-dengue immunoglobulin G (IgGs) present during infection can trigger progression to severe disease through antibody-dependent enhancement mechanisms. Importantly, specific characteristics of maternal IgGs that herald progression to severe infant dengue are unknown. Here, we define \u3e /=10% afucosylation of maternal anti-dengue IgGs as a risk factor for susceptibility of infants to symptomatic dengue infections. Mechanistic experiments show that afucosylation of anti-dengue IgGs promotes FcgammaRIIIa signaling during infection, in turn enhancing dengue virus replication in FcgammaRIIIa(+) monocytes. These studies identify a post-translational modification of anti-dengue IgGs that correlates with risk for symptomatic infant dengue infections and define a mechanism by which afucosylated antibodies and FcgammaRIIIa enhance dengue infections

Cephalopod resources in southeast and northeast coasts of India and Andaman - Nicobar waters

During 1988-'90, FORV Sagar Sampada has made 28 exclusive cruises to three regions in the Bay of Bengal covering different seasons of the year. Cephalopods formed one of the components of the demersal fishery resources of these regions, with the pelagic resources remaining insignificant. The commercially important neritic species of squids (Loligo duvauceli, Doryteuthis sibogae and Doryteuthis singhalensis), and cuttlefish (Sepia aculeata) were comparatively more in number and quantity than the species of oceanic squid Symplectoteuthis oualaniensis and other less important oceanic squids. The former groups of cephalopods were taken in demersal trawl and the latter in pelagic trawl. The distribution and relative abundance of various neritic and oceanic group of cephalopods by area and depth is given in the paper

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells

Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based transcriptome analysis was applied in epithelial-like MCF-7 and triple negative mesenchymal MDA-MB-231 breast cancer cells exposed to different concentrations of WA which can be detected systemically in in vivo experiments. Whereas WA treatment demonstrated attenuation of multiple cancer hallmarks, the withanolide analogue Withanone (WN) did not exert any of the described effects at comparable concentrations. Pathway enrichment analysis revealed that WA targets specific cancer processes related to cell death, cell cycle and proliferation, which could be functionally validated by flow cytometry and real-time cell proliferation assays. WA also strongly decreased MDA-MB-231 invasion as determined by single-cell collagen invasion assay. This was further supported by decreased gene expression of extracellular matrix-degrading proteases (uPA, PLAT, ADAM8), cell adhesion molecules (integrins, laminins), pro-inflammatory mediators of the metastasis-promoting tumor microenvironment (TNFSF12, IL6, ANGPTL2, CSF1R) and concomitant increased expression of the validated breast cancer metastasis suppressor gene (BRMS1). In line with the transcriptional changes, nanomolar concentrations of WA significantly decreased protein levels and corresponding activity of uPA in MDA-MB-231 cell supernatant, further supporting its anti-metastatic properties. Finally, hierarchical clustering analysis of 84 chromatin writer-reader-eraser enzymes revealed that WA treatment of invasive mesenchymal MDA-MB-231 cells reprogrammed their transcription levels more similarly towards the pattern observed in non-invasive MCF-7 cells. In conclusion, taking into account that sub-cytotoxic concentrations of WA target multiple metastatic effectors in therapy-resistant triple negative breast cancer, WA-based therapeutic strategies targeting the uPA pathway hold promise for further (pre)clinical development to defeat aggressive metastatic breast cancer