Regional similarities in the distributions of well yield from crystalline rocks in Fennoscandia

Well yields from Precambrian and Palaeozoic bedrock in Norway, Sweden and Finland exhibit very similar and approximately log-normal distributions: all three data sets exhibit a median yield of 600–700 L hr-1, despite the differences in climate and lithology. This similarity is tentatively reflected on a larger geographical scale by a meta-analysis of the international data sets on crystalline rock aquifers from other recently glaciated areas (i.e., without a thick regolith of weathered rock). An heuristic treatment of the Fennoscandian data sets suggests that this median yield is consistent with the following bulk properties of shallow (to c. 70–80 m depth) crystalline bedrock: transmissivity of 0.56 ± 0.30 m2 d-1 (6.4 ± 3.4 x 10-6 m2 s-1) and hydraulic conductivity of around 1.1 (± 0.6) x 10-7 m s-1

A ratio model of perceived speed in the human visual system

The perceived speed of moving images changes over time. Prolonged viewing of a pattern (adaptation) leads to an exponential decrease in its perceived speed. Similarly, responses of neurones tuned to motion reduce exponentially over time. It is tempting to link these phenomena. However, under certain conditions, perceived speed increases after adaptation and the time course of these perceptual effects varies widely. We propose a model that comprises two temporally tuned mechanisms whose sensitivities reduce exponentially over time. Perceived speed is taken as the ratio of these filters' outputs. The model captures increases and decreases in perceived speed following adaptation and describes our data well with just four free parameters. Whilst the model captures perceptual time courses that vary widely, parameter estimates for the time constants of the underlying filters are in good agreement with estimates of the time course of adaptation of direction selective neurones in the mammalian visual system

Talent management: the good, the bad, and the possible

In this essay we offer a critical investigation of talent management practices (TMP), which is an increasingly influential concept in contemporary organisations. We try to show how these organisational practices could have both a negative and a positive ethical impact on those identified as ‘talent’ within organisations. A critical analysis of how talent is defined, and how this impacts on individuals’ capacities for ethical reflection, allows us to highlight the ethical ambiguity inherent in talent management. We then highlight examples of some ‘bad’ consequences of TM, and explore some ‘good’ counter-examples. To highlight what may be ‘possible’ in talent management, we propose a more constructive relationship between talent management and ethics based on two dimensions: 1) the acceptance of ambiguity and personal struggle and 2) the development of more qualitative approaches to performance that could enable a better understanding of and sensitivity towards the broader context within which organisations function

Early-life telomere length predicts life-history strategy and reproductive senescence in a threatened wild songbird

Telomeres are well known for their associations with lifespan and ageing across diverse taxa. Early-life telomere length can be influenced by developmental conditions and has been shown positively affect lifetime reproductive success in a limited number of studies. Whether these effects are caused by a change in lifespan, reproductive rate or perhaps most importantly reproductive senescence is unclear. Using long-term data on female breeding success from a threatened songbird (the hihi, Notiomystis cincta), we show that the early-life telomere length of individuals predicts the presence and rate of future senescence of key reproductive traits: clutch size and hatching success. In contrast, senescence of fledging success is not associated with early-life telomere length, which may be due to the added influence of biparental care at this stage. Early-life telomere length does not predict lifespan or lifetime reproductive success in this species. Females may therefore change their reproductive allocation strategy depending on their early developmental conditions, which we hypothesise are reflected in their early-life telomere length. Our results offer new insights on the role that telomeres play in reproductive senescence and individual fitness and suggest telomere length can be used as a predictor for future life history in threatened species

Desmoplastic Small Round Cell Tumour of Childhood: A Report of Four Cases Demonstrating Wider Clinical Features and Variable Outcome

Purpose. Four further cases of desmoplastic small round cell tumour with multi phenotypic differentiation are described

The STARTWAVE atmospheric water database

International audienceThe STARTWAVE (STudies in Atmospheric Radiative Transfer and Water Vapour Effects) project aims to investigate the role which water vapour plays in the climate system, and in particular its interaction with radiation. Within this framework, an ongoing water vapour database project was set up which comprises integrated water vapour (IWV) measurements made over the last ten years by ground-based microwave radiometers, Global Positioning System (GPS) receivers and sun photometers located throughout Switzerland at altitudes between 330 and 3584 m. At Bern (46.95° N, 7.44° E) tropospheric and stratospheric water vapour profiles are obtained on a regular basis and integrated liquid water, which is important for cloud characterisation, is also measured. Additional stratospheric water vapour profiles are obtained by an airborne microwave radiometer which observes large parts of the northern hemisphere during yearly flight campaigns. The database allows us to validate the various water vapour measurement techniques. Comparisons between IWV measured by the Payerne radiosonde with that measured at Bern by two microwave radiometers, GPS and sun photometer showed instrument biases within ±0.5 mm. The bias in GPS relative to sun photometer over the 2001 to 2004 period was ?0.8 mm at Payerne (46.81° N, 6.94° E, 490 m), which lies in the Swiss plains north of the Alps, and +0.6 mm at Davos (46.81° N, 9.84° E, 1598 m), which is located within the Alps in the eastern part of Switzerland. At Locarno (46.18° N, 8.78° E, 366 m), which is located on the south side of the Alps, the bias is +1.9 mm. The sun photometer at Locarno was found to have a bias of ?2.2 mm (13% of the mean annual IWV) relative to the data from the closest radiosonde station at Milano. This result led to a yearly rotation of the sun photometer instruments between low and high altitude stations to improve the calibrations. In order to demonstrate the capabilites of the database for studying water vapour variations, we investigated a front which crossed Switzerland between 18 November 2004 and 19 November 2004. During the frontal passage, the GPS and microwave radiometers at Bern and Payerne showed an increase in IWV of between 7 and 9 mm. The GPS IWV measurements were corrected to a standard height of 500 m, using an empirically derived exponential relationship between IWV and altitude. A qualitative comparison was made between plots of the IWV distribution measured by the GPS and the 6.2 µm water vapour channel on the Meteosat Second Generation (MSG) satellite. Both showed that the moist air moved in from a northerly direction, although the MSG showed an increase in water vapour several hours before increases in IWV were detected by GPS or microwave radiometer. This is probably due to the fact that the satellite instrument is sensitive to an atmospheric layer at around 320 hPa, which makes a contribution of one percent or less to the IWV

TRAINING CENTRE FOR ENERGY TRADING

Reforme energetskog sektora i nove poslovne mogućnosti nametnule su potrebu stjecanja i prenošenja znanja i vještina svim sudionicima koji preuzimaju nove uloge i odgovornosti u energetskom sektoru. Stoga su Fakultet elektrotehnike i računarstva Sveučilišta u Zagrebu (FER), Hrvatska elektroprivreda d.d. (HEP d.d.) i norveška tvrtka Technor Energy AS pokrenule projekt uspostave Trening centra za trgovanje energijom (Training Centre for Energy Trading TCET). U članku je predstavljen rezultat ove suradnje – pisani materijali koji služe kao podloga za učenje i simulator tržišta koji omogućava različitim tržišnim sudionicima, iz raznih zemalja i s različitim tržišnim interesima, da kroz igru iskušaju tržišno natjecanje. Ovo je prvi trening centar takve vrste u Europi, a projekt njegove uspostave financiralo je Ministarstvo vanjskih poslova Kraljevine Norveške i HEP d.d.The current reforms in the energy sector and the resulting new business opportunities have imposed a need for knowledge and skills to be acquired by or imparted to all those who will assume new roles and responsibilities in the energy sector. To this end the Faculty of Electrical Engineering and Computering of the University of Zagreb (FER), Hrvatska elektroprivreda d.d. – The Croatian Electricity Company (HEP d.d.) and the Norwegian company Technor Energy AS launched a project to establish the Training Centre for Energy Trading (TCET). This article presents the results of this co-operation – printed materials to serve as teaching aid and a market simulator to help various market participants from different countries and with different market interests to try their hand at market competition by playing games. This is the first training centre project of this kind in Europe, co-financed by the Ministry for Foreign Affairs of the Kingdom of Norway and HEP d.d

A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin

Pre-clinical studies indicate that cisplatin encapsulated in STEALTH®liposomes (SPI-77) retains anti-tumour activity, but has a much reduced toxicity, compared to native cisplatin. A phase I study was conducted to determine the toxicity and pharmacokinetics of SPI-77 administered to children with advanced cancer not amenable to other treatment. Paediatric patients were treated at doses ranging from 40 to 320 mg m−2by intravenous infusion every 4 weeks. Blood samples taken during, and up to 3 weeks after, administration and plasma and ultrafiltrate were prepared immediately. Urine was collected, when possible, for 3 days after administration. SPI-77 administration was well tolerated with the major toxicity being an infusion reaction which responded to modification of the initial infusion rate of SPI-77. Limited haematological toxicity and no nephrotoxicity were observed. No responses to treatment were seen during the course of this phase I study. Measurement of total plasma platinum showed that cisplatin was retained in the circulation with a half life of up to 134 h, with maximum plasma concentrations approximately 100-fold higher than those reported following comparable doses of cisplatin. Comparison of plasma and whole blood indicated that cisplatin was retained in the liposomes and there was no free platinum measurable in the ultrafiltrate. Urine recovery was less than 4% of the dose administered over 72 h. Results from this phase I study indicate that high doses of liposomal cisplatin can safely be given to patients, but further studies are required to address the issue of reformulation of liposomally bound cisplatin. © 2001 Cancer Research Campaign http://www.bjcancer.co

Body Burdens of Polybrominated Diphenyl Ethers among Urban Anglers

Polybrominated diphenyl ethers (PBDEs) have been widely used in the United States and worldwide as flame retardants. Recent PBDE production figures show that worldwide use has increased. To determine whether fish consumption is a source of PBDE exposure for humans, a cross-sectional epidemiologic study of New York and New Jersey urban anglers was conducted during the summers of 2001–2003. Frequency of local fish consumption was assessed by questionnaire, and blood samples for PBDE analysis were collected from 94 anglers fishing from piers on the lower Hudson River and Newark Bay. We analyzed PBDEs by gas chromatography–isotope dilution–high-resolution mass spectrometry. The congeners found in anglers’ serum at the highest concentrations were, by International Union of Pure and Applied Chemistry numbers, BDE-47, BDE-153, and BDE-99. Anglers reporting consumption of local fish had higher, but nonstatistically significantly different, concentrations of PBDEs than did anglers who did not eat local fish. For some congeners (BDE-100 and BDE-153), we observed moderate dose–response relationships between serum PBDE levels and frequency of reported fish intake. These findings suggest that consumption of locally caught fish is not a major route of human exposure for this study population