Search for Global Metric Anisotropy in Type Ia Supernova Data

We examine the Type 1a supernova data in order to determine if it shows any signal of large scale anisotropy. The anisotropy is modelled by an extended G\"{o}del metric, which incorporates expansion along with rotation. The model is smoothly connected to the usual FRW type, while expressing anisotropic metric effects depending on certain parameters. We find no significant signal of anisotropy in the data. We obtain bounds on an anisotropic redshift versus magnitude relationship, and accompanying parameters of the G\"{o}del-Obukhov metric.Comment: 16 pages, 2 figures, minor changes, to be published in Modern Physics Letters

Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission

Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) is a monomeric clathrin adaptor that has been shown to regulate the trafficking of the Beta-site APP-cleaving enzyme (BACE1), which is required for production of the Alzheimer’s disease (AD)-associated amyloid βpeptide. Our previous studies have shown that BACE1 is degraded via the lysosomal pathway and that depletion of GGA3 results in increased BACE1 levels and activity owing to impaired lysosomal trafficking and degradation. We further demonstrated the role of GGA3 in the regulation of BACE1 in vivo by showing that BACE1 levels are increased in the brain of GGA3 null mice. We report here that GGA3 deletion results in novelty-induced hyperactivity and decreased anxiety-like behaviors. Given the pivotal role of GABAergic transmission in the regulation of anxiety-like behaviors, we performed electrophysiological recordings in hippocampal slices and found increased phasic and decreased tonic inhibition in the dentate gyrus granule cells (DGGC). Moreover, we found that the number of inhibitory synapses is increased in the dentate gyrus of GGA3 null mice in further support of the electrophysiological data. Thus, the increased GABAergic transmission is a leading candidate mechanism underlying the reduced anxiety-like behaviors observed in GGA3 null mice. All together these findings suggest that GGA3 plays a key role in GABAergic transmission. Since BACE1 levels are elevated in the brain of GGA3 null mice, it is possible that at least some of these phenotypes are a consequence of increased processing of BACE1 substrates

Orbital resonances in discs around braneworld Kerr black holes

Rotating black holes in the brany universe of the Randall-Sundrum type are described by the Kerr geometry with a tidal charge b representing the interaction of the brany black hole and the bulk spacetime. For b<0 rotating black holes with dimensionless spin a>1 are allowed. We investigate the role of the tidal charge b in the orbital resonance model of QPOs in black hole systems. The orbital Keplerian, the radial and vertical epicyclic frequencies of the equatorial, quasicircular geodetical motion are given and their radial profiles are discussed. The resonant conditions are given in three astrophysically relevant situations: for direct (parametric) resonances, for the relativistic precession model, and for some trapped oscillations of the warped discs, with resonant combinational frequencies. It is shown, how b could influence matching of the observational data indicating the 3:2 frequency ratio observed in GRS 1915+105 microquasar with prediction of the orbital resonance model; limits on allowed range of the black hole parameters a and b are established. The "magic" dimensionless black hole spin enabling presence of strong resonant phenomena at the radius where \nu_K:\nu_{\theta}:\nu_r=3:2:1 is determined in dependence on b. Such strong resonances could be relevant even in sources with highly scattered resonant frequencies, as those expected in Sgr A*. The specific values of a and b are given also for existence of specific radius where \nu_K:\nu_{\theta}:\nu_r=s:t:u with 5>=s>t>u being small natural numbers. It is shown that for some ratios such situation is impossible in the field of black holes. We can conclude that analysing the microquasars high-frequency QPOs in the framework of orbital resonance models, we can put relevant limits on the tidal charge of brany Kerr black holes.Comment: 31 pages, 19 figures, to appear in General Relativity and Gravitatio

Goal-Driven Structured Argumentation for Patient Management in a Multimorbidity Setting

We use computational argumentation to both analyse and generate solutions for reasoning in multimorbidity about consistent recommendations, according to different patient-centric goals. Reasoning in this setting carries a complexity related to the multiple variables involved. These variables reflect the co-existing health conditions that should be considered when defining a proper therapy. However, current Clinical Decision Support Systems (CDSSs) are not equipped to deal with such a situation. They do not go beyond the straightforward application of the rules that build their knowledge base and simple interpretation of Computer-Interpretable Guidelines (CIGs). We provide a computational argumentation system equipped with goal-seeking mechanisms to combine independently generated recommendations, with the ability to resolve conflicts and generate explanations for its results. We also discuss its advantages over and relation to Multiple-criteria Decision-making (MCDM) in this particular setting.- (undefined

Computing Argument Preferences and Explanations in Abstract Argumentation

Financial support from The UK Engineering and Physical Sciences Research Council (EPSRC) for the grant (EP/P011829/1), Supporting Security Policy with Effective Digital Intervention (SSPEDI) is gratefully acknowledged.Postprin

Six-dimensional localized black holes: numerical solutions

To test the strong-gravity regime in Randall-Sundrum braneworlds, we consider black holes bound to a brane. In a previous paper, we studied numerical solutions of localized black holes whose horizon radii are smaller than the AdS curvature radius. In this paper, we improve the numerical method and discuss properties of the six dimensional (6D) localized black holes whose horizon radii are larger than the AdS curvature radius. At a horizon temperature $\mathcal{T} \approx 1/2\pi \ell$, the thermodynamics of the localized black hole undergo a transition with its character changing from a 6D Schwarzschild black hole type to a 6D black string type. The specific heat of the localized black holes is negative, and the entropy is greater than or nearly equal to that of the 6D black strings with the same thermodynamic mass. The large localized black holes show flattened horizon geometries, and the intrinsic curvature of the horizon four-geometry becomes negative near the brane. Our results indicate that the recovery mechanism of lower-dimensional Einstein gravity on the brane works even in the presence of the black holes.Comment: 17 pages, 9 figures, RevTeX4, typos correcte

Small localized black holes in a braneworld: Formulation and numerical method

No realistic black holes localized on a 3-brane in the Randall-Sundrum infinite braneworld have been found so far. The problem of finding a static black hole solution is reduced to a boundary value problem. We solve it by means of a numerical method, and show numerical examples of a localized black hole whose horizon radius is small compared to the bulk curvature scale. The sequence of small localized black holes exhibits a smooth transition from a five-dimensional Schwarzschild black hole, which is a solution in the limit of small horizon radius. The localized black hole tends to flatten as its horizon radius increases. However, it becomes difficult to find black hole solutions as its horizon radius increases.Comment: RevTeX, 13 pages, 6 figures, references corrected, typos corrected; to appear in Phys.Rev.

Surgical and minimally invasive treatment of ischaemic and non-ischaemic priapism : A systematic review by the EAU Sexual and Reproductive Health Guidelines panel

Peer reviewedPostprin