2,261 research outputs found
Vasopressin als Reservevasopressor: Behandlung ausgewählter kardiogener Schockzustände
Zusammenfassung: Der vasodilatorische Schock ist die häufigste Schockform des Intensivpatienten. Als Folge übermäßiger und prolongierter Mediatorproduktion kann der vasodilatorische Schock auch aus primär nichtvasodilatorischen Schockzuständen (z.B. kardiogener oder hypovolämer Schock) entstehen. Eine zusätzliche Infusion mit Arginin Vasopressin (AVP) zeigte vorteilhafte Effekte auf die Hämodynamik und wahrscheinlich auch das Outcome bei Patienten mit vasodilatorischem Schock durch Sepsis oder nach großen chirurgischen Eingriffen. In dieser Fallsammlung wird über die erfolgreiche Anwendung von AVP bei drei chirurgischen Intensivpatienten mit primär kardiogenen Schockzuständen berichtet. Die hämodynamischen Effekte von AVP waren den im septischen Schock berichteten AVP-induzierten Veränderungen sehr ähnlich. Diese scheinen auch bei den beschriebenen Patienten maßgeblich durch die potente Vasokonstriktion sowie die ermöglichte Reduktion hoher, potenziell toxischer Katecholamindosierungen bedingt zu sein. Dabei dürfte gerade die AVP-vermittelte Reduktion der Herzfrequenz und der pulmonalarteriellen Drücke bei Patienten mit eingeschränkter kardialer Funktion von Vorteil sei
Polaronic excitations in CMR manganite films
In the colossal magnetoresistance manganites polarons have been proposed as
the charge carrier state which localizes across the metal-insulator transition.
The character of the polarons is still under debate. We present an assessment
of measurements which identify polarons in the metallic state of
La{2/3}Sr{1/3}MnO{3} (LSMO) and La{2/3}Ca{1/3}MnO{3} (LCMO) thin films. We
focus on optical spectroscopy in these films which displays a pronounced
resonance in the mid-infrared. The temperature dependent resonance has been
previously assigned to polaron excitations. These polaronic resonances are
qualitatively distinct in LSMO and LCMO and we discuss large and small polaron
scenarios which have been proposed so far. There is evidence for a large
polaron excitation in LSMO and small polarons in LCMO. These scenarios are
examined with respect to further experimental probes, specifically charge
carrier mobility (Hall-effect measurements) and high-temperature
dc-resistivity.Comment: 16 pages, 10 figure
Transport, magnetic, thermodynamic and optical properties in Ti-doped Sr_2RuO_4
We report on electrical resistivity, magnetic susceptibility and
magnetization, on heat capacity and optical experiments in single crystals of
Sr_2Ru_(1-x)Ti_xO_4. Samples with x=0.1 and 0.2 reveal purely semiconducting
resistivity behavior along c and the charge transport is close to localization
within the ab-plane. A strong anisotropy in the magnetic susceptibility appears
at temperatures below 100 K. Moreover magnetic ordering in c-direction with a
moment of order 0.01 mu_B/f.u. occurs at low temperatures. On doping the
low-temperature linear term of the heat capacity becomes reduced significantly
and probably is dominated by spin fluctuations. Finally, the optical
conductivity reveals the anisotropic character of the dc resistance, with the
in-plane conductance roughly following a Drude-type behavior and an insulating
response along c
Evolution of Quantum Criticality in CeNi_{9-x}Cu_xGe_4
Crystal structure, specific heat, thermal expansion, magnetic susceptibility
and electrical resistivity studies of the heavy fermion system
CeNi_{9-x}Cu_xGe_4 (0 <= x <= 1) reveal a continuous tuning of the ground state
by Ni/Cu substitution from an effectively fourfold degenerate non-magnetic
Kondo ground state of CeNi_9Ge_4 (with pronounced non-Fermi-liquid features)
towards a magnetically ordered, effectively twofold degenerate ground state in
CeNi_8CuGe_4 with T_N = 175 +- 5 mK. Quantum critical behavior, C/T ~ \chi ~
-ln(T), is observed for x about 0.4. Hitherto, CeNi_{9-x}Cu_xGe_4 represents
the first system where a substitution-driven quantum phase transition is
connected not only with changes of the relative strength of Kondo effect and
RKKY interaction, but also with a reduction of the effective crystal field
ground state degeneracy.Comment: 15 pages, 9 figure
Universal exchange-driven phonon splitting in antiferromagnets
We report a linear dependence of the phonon splitting \Delta\omega on the
non-dominant exchange coupling constant J_{nd} in the antiferromagnetic
transition-metal monoxides MnO, FeO, CoO, NiO, and in the frustrated
antiferromagnetic oxide spinels CdCr2O4, MgCr2O4, and ZnCr2O4. It directly
confirms the theoretical prediction of an exchange induced splitting of the
zone-centre optical phonon for the monoxides and explains the magnitude and the
change of sign of the phonon splitting on changing the sign of the non-dominant
exchange also in the frustrated oxide spinels. The experimentally found linear
relation \hbar\Delta\omega = \beta J_{nd} S^2 with slope \beta = 3.7 describes
the splitting for both systems and agrees with the observations in the
antiferromagnets KCoF3 and KNiF3 with perovskite structure and negligible
next-nearest neighbour coupling. The common behavior found for very different
classes of cubic antiferromagnets suggests a universal dependence of the
exchange-induced phonon splitting at the antiferromagnetic transition on the
non-dominant exchange coupling.Comment: 5 pages, 4 figure
Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest.
In animal models, immune activation is often difficult to assess because of the limited availability of specific assays to detect cytokine activities. In human monocytes/macrophages, interferon-gamma induces increased production of neopterin and an enhanced activity of indoleamine 2,3-dioxygenase, which degrades tryptophan via the kynurenine pathway. Therefore, monitoring of neopterin concentrations and of tryptophan degradation can serve to detect the extent of T helper cell 1-type immune activation during cellular immune response in humans. In a porcine model of cardiac arrest, we examined the potential use of neopterin measurements and determination of the tryptophan degradation rate as a means of estimating the extent of immune activation. Urinary neopterin concentrations were measured with high-performance liquid chromatography (HPLC) and radioimmunoassay (RIA) (BRAHMS Diagnostica, Berlin, Germany). Serum and plasma tryptophan and kynurenine concentrations were also determined using HPLC. Serum and urine neopterin concentrations were not detectable with HPLC in these specimens, whereas RIA gave weakly (presumably false) positive results. The mean serum tryptophan concentration was 39.0 +/- 6.2 micromol/l, and the mean kynurenine concentration was 0.85 +/- 0.33 micromol/l. The average kynurenine-per-tryptophan quotient in serum was 21.7 +/- 8.4 nmol/micromol, and that in plasma was 20.7 +/- 9.5 nmol/micromol (n = 7), which corresponds well to normal values in humans. This study provides preliminary data to support the monitoring of tryptophan degradation but not neopterin concentrations as a potential means of detecting immune activation in a porcine model. The kynurenine-per-tryptophan quotient may serve as a short-term measurement of immune activation and hence permit an estimate of the extent of immune activation
On elliptic solutions of the quintic complex one-dimensional Ginzburg-Landau equation
The Conte-Musette method has been modified for the search of only elliptic
solutions to systems of differential equations. A key idea of this a priory
restriction is to simplify calculations by means of the use of a few Laurent
series solutions instead of one and the use of the residue theorem. The
application of our approach to the quintic complex one-dimensional
Ginzburg-Landau equation (CGLE5) allows to find elliptic solutions in the wave
form. We also find restrictions on coefficients, which are necessary conditions
for the existence of elliptic solutions for the CGLE5. Using the investigation
of the CGLE5 as an example, we demonstrate that to find elliptic solutions the
analysis of a system of differential equations is more preferable than the
analysis of the equivalent single differential equation.Comment: LaTeX, 21 page
Poly-MTO, {(CH_3)_{0.92} Re O_3}_\infty, a Conducting Two-Dimensional Organometallic Oxide
Polymeric methyltrioxorhenium, {(CH_{3})_{0.92}ReO_{3}}_{\infty} (poly-MTO),
is the first member of a new class of organometallic hybrids which adopts the
structural pattern and physical properties of classical perovskites in two
dimensions (2D). We demonstrate how the electronic structure of poly-MTO can be
tailored by intercalation of organic donor molecules, such as
tetrathiafulvalene (TTF) or bis-(ethylendithio)-tetrathiafulvalene (BEDT-TTF),
and by the inorganic acceptor SbF. Integration of donor molecules leads to
a more insulating behavior of poly-MTO, whereas SbF insertion does not
cause any significant change in the resistivity. The resistivity data of pure
poly-MTO is remarkably well described by a two-dimensional electron system.
Below 38 K an unusual resistivity behavior, similar to that found in doped
cuprates, is observed: The resistivity initially increases approximately as
ln) before it changes into a dependence below 2 K.
As an explanation we suggest a crossover from purely two-dimensional
charge-carrier diffusion within the \{ReO\} planes at high
temperatures to three-dimensional diffusion at low temperatures in a
disorder-enhanced electron-electron interaction scenario (Altshuler-Aronov
correction). Furthermore, a linear positive magnetoresistance was found in the
insulating regime, which is caused by spatial localization of itinerant
electrons at some of the Re atoms, which formally adopt a electronic
configuration. X-ray diffraction, IR- and ESR-studies, temperature dependent
magnetization and specific heat measurements in various magnetic fields suggest
that the electronic structure of poly-MTO can safely be approximated by a
purely 2D conductor.Comment: 15 pages, 16 figures, 2 table
Lack of complex I is associated with oncocytic thyroid tumours
Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue
Non-Perturbative Superpotentials in F-theory and String Duality
We use open-closed string duality between F-theory on K3xK3 and type II
strings on CY manifolds without branes to study non-perturbative
superpotentials in generalized flux compactifications. On the F-theory side we
obtain the full flux potential including D3-instanton contributions and show
that it leads to an explicit and simple realization of the three ingredients of
the KKLT model for stringy dS vacua. The D3-instanton contribution is highly
non-trivial, can be systematically computed including the determinant factors
and demonstrates that a particular flux lifts very effectively zero modes on
the instanton. On the closed string side, we propose a generalization of the
Gukov-Vafa-Witten superpotential for type II strings on generalized CY
manifolds, depending on all moduli multiplets.Comment: 49 pages, harvmac, 1 figure; references & figures adde
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