Impact of historical tsunamis on a sandy coastal barrier: an example from the northern Gargano coast, southern Italy

International audienceThe Lesina coastal barrier is characterized by the presence of three wide washover fans. They were formed by three distinct tsunamis which struck the northern coast of the Gargano Promontory (Apulia, Italy) during historical times. A model for their formation is presented. It takes into account the geomorphological data collected and some reports about the effect of recent tsunamis on coastal barriers and beaches. Washover fans were produced by tsunami waves which ran through coseismic cracks developed on dune ridges shaping a narrow, straight and relatively deep trench which constitutes the fan throat. Moreover, each tsunami event most likely caused severe erosion of the coastal barrier, shaping erosive grooves across the dune ridges, causing beach cliffs and causing the nourishment of submarine offshore bars. After the tsunami, a phase of coastal barrier recovery began, forming new dune ridges and closing washover fan throats. Morphological, archeological and radiometric data indicate a pre-Roman age for the oldest event, which was dated at 2430 years BP. The second tsunami struck the Lesina coastal barrier with similar magnitude 1550 years BP; it was caused by the strong earthquake that occurred at Gargano Promontory in the year 493 AD as reported by a medieval sacred legend. The smallest and more recent fan formed following the tsunami that hit the northern coast of Gargano on 30 July 1627

Note di archeologia nei “Bozzetti di viaggio”

Cosimo De Giorgi was an eminent scholar, involved in many fields of knowledge. He also dealt with archaeology by directing excavations in the area of the Lecce’s amphitheatre in the very early years of the 20th century. On the other hand, he had gone through a long period of ‘self-education’ developing an intense field activity that included observation and documentation of anthropic and natural phenomena. The “Bozzetti di Viaggio” fixed this phase of De Giorgi’s life and they constitute a useful tool for modern-day archaeology as well; in fact they can help us to take a journey back in time and see with De Giorgi’s eyes what the Salento peninsula looked like 150 years ago

Insediamenti e territorio nella Puglia meridionale in età romana

This paper aims to offer a summary of the archaeological data coming from southern Apulia and referring to population dynamics in the Roman age. Through the investigation of the long period going from the Roman conquest in the third century B.C. up to the late imperial age, we analyse the changes in settlement system in relation to the historical framework and to socio-political, administrative and economic structures. We also propose some observations about the presence of the best known categories of artefacts, mainly examining the aspects of production and circulation of the pottery classes

Quantitative analysis of extensional joints in the southern Adriatic foreland (Italy), and the active tectonics of the Apulia region

The Adriatic foreland of the Apennines comes ashore only in Apulia (easternmost Italy). Its southern part, our study area, lacks any structural analysis devoted to define its recent-to-active tectonics. Throughout the Quaternary, this region was affected by mild brittle deformation with rare faults, characterized by small displacement, and widespread extension joints, frequently organized in sets. Therefore, we conducted a quantitative and systematic analysis of the joint sets affecting Quaternary deposits, by applying an inversion technique ad hoc to infer the orientation and ratio of the principal stress axes, R = (σ2 - σ3)/(σ1 - σ3). Within a general extensional regime, we recognized three deformational events of regional significance. The oldest event, constrained to the early and middle part of the Middle Pleistocene, is characterized by variable direction of extension and R between 0.64-0.99. The penultimate event, dated late Middle Pleistocene, is characterized by an almost uniaxial tension, with a horizontal σ3 striking ~N43°E; R is high, between 0.85-0.99. The most recent event is characterized by the lowermost R values, that never exceed 0.47 and are frequently <0.30, indicating a sort of horizontal „radial‟ extension. This event is not older than the Late Pleistocene and possibly reflects the active stress field still dominating the entire study area

Quantitative analysis of extensional joints in the southern Adriatic foreland (Italy), and the active tectonics of the Apulia region

The Adriatic foreland of the Apennines comes ashore only in Apulia (easternmost Italy). Its southern part, our study area, lacks any structural analysis devoted to define its recent-to-active tectonics. Throughout the Quaternary, this region was affected by mild brittle deformation with rare faults, characterized by small displacement, and widespread extension joints, frequently organized in sets. Therefore, we conducted a quantitative and systematic analysis of the joint sets affecting Quaternary deposits, by applying an inversion technique ad hoc to infer the orientation and ratio of the principal stress axes, R = (σ2 − σ3)/(σ1 − σ3). Within a general extensional regime, we recognized three deformational events of regional significance. The oldest event, constrained to the early and middle part of the Middle Pleistocene, is characterized by variable direction of extension and R between 0.64 and 0.99. The penultimate event, dated late Middle Pleistocene, is characterized by an almost uniaxial tension, with a horizontal σ3 striking ∼N43°E; R is high, between 0.85 and 0.99. The most recent event is characterized by the lowermost R values, that never exceed 0.47 and are frequently <0.30, indicating a sort of horizontal ‘radial’ extension. This event is not older than the Late Pleistocene and possibly reflects the active stress field still dominating the entire study area

Holocene Sea Level Recorded by Beach Rocks at Ionian Coasts of Apulia (Italy)

Beach rocks are located along many coasts of the Mediterranean basin. The early diagenesis environment and the mean sea level along the shoreline make these landforms useful in the reconstruction of relative sea-level changes and, in particular, as SLIPs (sea-level index points). The beach rocks surveyed along the Ionian coast of Apulia were found to be well preserved at three specific depth ranges: 6–9 m, 3–4 m, and from the foreshore to about 1.20 m. Morpho-bathymetric and dive surveys were performed to assess both the geometries and the extension of the submerged beach rocks. Samples were collected at these different depths in the localities of Lido Torretta, Campomarino di Maruggio, San Pietro in Bevagna, and Porto Cesareo. Bivalve shells were identified and isolated from the beach rock samples collected at a depth of 7 m; AMS dating provided a calibrated age of about 7.8 ka BP. Their morphology and petrological features, along with the time constraints, enabled us to (i) reconstruct the local sea-level curve during the Holocene, (ii) corroborate acquired knowledge of the relative sea-level history, and (iii) identify possible local vertical land movement (VLM)

Canonical and noncanonical roles of Fanconi anemia proteins: Implications in cancer predisposition

Fanconi anemia (FA) is a clinically and genetically heterogeneous disorder characterized by the variable presence of congenital somatic abnormalities, bone marrow failure (BMF), and a predisposition to develop cancer. Monoallelic germline mutations in at least five genes involved in the FA pathway are associated with the development of sporadic hematological and solid malignancies. The key function of the FA pathway is to orchestrate proteins involved in the repair of interstrand cross-links (ICLs), to prevent genomic instability and replication stress. Recently, many studies have highlighted the importance of FA genes in noncanonical pathways, such as mitochondria homeostasis, inflammation, and virophagy, which act, in some cases, independently of DNA repair processes. Thus, primary defects in DNA repair mechanisms of FA patients are typically exacerbated by an impairment of other cytoprotective pathways that contribute to the multifaceted clinical phenotype of this disease. In this review, we summarize recent advances in the understanding of the pathogenesis of FA, with a focus on the cytosolic noncanonical roles of FA genes, discussing how they may contribute to cancer development, thus suggesting opportunities to envisage novel therapeutic approaches

Cerebrospinal fluid levels of AFP and hCG: Validation of the analytical method and application in the diagnosis of central nervous system germ cell tumors

The determination of Human Chorionic Gonadotropin (hCG) and Alpha Fetoprotein (AFP) levels on serum and amniotic fluid plays a fundamental role in the diagnosis and follow-up of specific physiological or pathological conditions (e.g., pregnancy, threat of abortion or germ cell tumors). Recently, the quantification of hCG and AFP in other biological fluids has gained great attention to support the diagnosis, prognosis and follow-up of neoplastic diseases deriving from trophoblastic cells, such as germinomas. Most of the commercial kits for hCG and AFP assays are developed to be used on biological fluids such as serum/plasma and/or urine by manufacturing companies. The aim of this work was to evaluate the suitability of the analytical method certified for the use on serum, and/or amniotic fluid for the quantification of hCG and AFP in cerebrospinal fluid, carrying out an internal validation protocol. The data reported here show that the automated immunochemical method is fit for quantification of hCG and AFP in cerebrospinal fluid (CSF), allowing selective and specific diagnosis of secreting germ cell tumors. This is confirmed by the positive correlation between elevated levels of hCG or AFP and the diagnosis of brain tumors

New evidence of mis 3 relative sea level changes from the messina strait, Calabria (Italy)

none12Investigation of sea-level positions during the highly-dynamic Marine Isotope Stage 3 (MIS 3: 29–61 kyrs BP) proves difficult because: (i) in stable and subsiding areas, coeval coastal sediments are currently submerged at depths of few to several tens of meters below the present sea level; (ii) in uplifting areas, the preservation of geomorphic features and sedimentary records is limited due to the erosion occurred during the Last Glacial Maximum (LGM) with sea level at a depth of −130 m, followed by marine transgression that determined the development of ravinement surfaces. This study discusses previous research in the Mediterranean and elsewhere, and describes new fossiliferous marine deposits overlaying the metamorphic bedrock at Cannitello (Calabria, Italy). Radiocarbon ages of marine shells (about 43 kyrs cal BP) indicate that these deposits, presently between 28 and 30 m above sea level, formed during MIS 3.1. Elevation correction of the Cannitello outcrops (considered in an intermediate-to-far-field position with respect to the ice sheet) with the local vertical tectonic rate and Glacial Isostatic Adjustment (GIA) rate allows the proposal of a revision of the eustatic depth for this highstand. Our results are consistent with recently proposed estimates based on a novel ice sheet modelling technique.openAntonioli F.; Calcagnile L.; Ferranti L.; Mastronuzzi G.; Monaco C.; Orru P.; Quarta G.; Pepe F.; Scardino G.; Scicchitano G.; Stocchi P.; Taviani M.Antonioli, F.; Calcagnile, L.; Ferranti, L.; Mastronuzzi, G.; Monaco, C.; Orru, P.; Quarta, G.; Pepe, F.; Scardino, G.; Scicchitano, G.; Stocchi, P.; Taviani, M

Infantile/congenital high-grade gliomas: molecular features and therapeutic perspectives

Brain tumors in infants account for less than 10% of all pediatric nervous system tumors. They include tumors diagnosed in fetal age, neonatal age and in the first years of life. Among these, high-grade gliomas (HGGs) are a specific entity with a paradoxical clinical course that sets them apart from their pediatric and adult counterparts. Currently, surgery represents the main therapeutic strategy in the management of these tumors. Chemotherapy does not have a well-defined role whilst radiotherapy is rarely performed, considering its late effects. Information about molecular characterization is still limited, but it could represent a new fundamental tool in the therapeutic perspective of these tumors. Chimeric proteins derived from the fusion of several genes with neurotrophic tyrosine receptor kinase mutations have been described in high-grade gliomas in infants as well as in neonatal age and the recent discovery of targeted drugs may change the long-term prognosis of these tumors, along with other target-driven therapies. The aim of this mini review is to highlight the recent advances in the diagnosis and treatment of high-grade gliomas in infants with a particular focus on the molecular landscape of these neoplasms and future clinical applications