2,237 research outputs found
The impact of shocks on the chemistry of molecular clouds: high resolution images of chemical differentiation along the NGC1333-IRAS2A outflow
This paper presents a detailed study of the chemistry in the outflow
associated with the low-mass protostar NGC1333-IRAS2A down to 3" (650 AU)
scales. Millimeter-wavelength aperture-synthesis observations from the OVRO and
BIMA interferometers and (sub)millimeter single-dish observations from the
Onsala 20m telescope and CSO are presented. The interaction of the highly
collimated protostellar outflow with a molecular condensation ~15000 AU from
the central protostar is clearly traced by molecular species such as HCN, SiO,
SO, CS, and CH3OH. Especially SiO traces a narrow high velocity component at
the interface between the outflow and the molecular condensation.
Multi-transition single-dish observations are used to distinguish the chemistry
of the shock from that of the molecular condensation and to address the
physical conditions therein. Statistical equilibrium calculations reveal
temperatures of 20 and 70 K for the quiescent and shocked components,
respectively, and densities near 10^6 cm^{-3}. Significant abundance
enhancements of two to four orders of magnitude are found in the shocked region
for molecules such as CH3OH, SiO and the sulfur-bearing molecules. HCO+ is seen
only in the aftermath of the shock consistent with models where it is destroyed
through release of H2O from grain mantles in the shock. N2H+ shows narrow
lines, not affected by the outflow but rather probing the ambient cloud.
Differences in abundances of HCN, H2CO and CS are seen between different
outflow regions and are suggested to be related to differences in the atomic
carbon abundance. Compared to the warm inner parts of protostellar envelopes,
higher abundances of in particular CH3OH and SiO are found in the outflows,
which may be related to density differences between the regions.Comment: 18 pages, 13 figures. Accepted for publication in A&
The compact far infrared emission from the young stellar object IRAS 16293-2422
High resolution far IR observations at 50 and 100 microns were made of the young stellar object (YSO), IRAS 16293-2422. The observations are part of a systematic high resolution study of nearby YSO's. The purpose is to obtain resolution in the far IR comparable to that at other wavelengths. Until recently, the high resolution that has been available in the far IR has been from either IRAS (angular resolution of approx 4 min) or the KAO using standard FIR photometry (approx 35 sec). With scanning techniques, it is possible to obtain 10 sec resolution on bright sources. Such a resolution is necessary to better determine the physical conditions of the YSO, and to compare with model of star formation. In order to better constrain the models for the source, the YSO was observed at both 50 and 100 microns on several flights in 1988 April from the KAO. Estimates are presented of the size both along the major and minor axis of the disk, as well as estimates of the dust temperature and 100 micron opacity for the YSO
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Methods for treating bone deficit conditions with benzothiazole
" Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or ""linker"" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems. "Board of Regents, University of Texas Syste
Inferring metabolic mechanisms of interaction within a defined gut microbiota
The diversity and number of species present within microbial communities create the potential for a multitude of interspecies metabolic interactions. Here, we develop, apply, and experimentally test a framework for inferring metabolic mechanisms associated with interspecies interactions. We perform pairwise growth and metabolome profiling of co-cultures of strains from a model mouse microbiota. We then apply our framework to dissect emergent metabolic behaviors that occur in co-culture. Based on one of the inferences from this framework, we identify and interrogate an amino acid cross-feeding interaction and validate that the proposed interaction leads to a growth benefit in vitro. Our results reveal the type and extent of emergent metabolic behavior in microbial communities composed of gut microbes. We focus on growth-modulating interactions, but the framework can be applied to interspecies interactions that modulate any phenotype of interest within microbial communities
Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon
Simian immunodeficiency viruses (SIVcpz) infecting chimpanzees (Pan troglodytes) in west central Africa are the closest relatives to all major variants of human immunodeficiency virus type 1 ([HIV-1]; groups M, N and O), and have thus been implicated as the source of the human infections; however, information concerning the prevalence, geographic distribution, and subspecies association of SIVcpz still remains limited. In this study, we tested 71 wild-caught chimpanzees from Cameroon for evidence of SIVcpz infection. Thirty-nine of these were of the central subspecies (Pan troglodytes troglodytes), and 32 were of the Nigerian subspecies (Pan troglodytes vellerosus), as determined by mitochondrial DNA analysis. Serological analysis determined that one P. t. troglodytes ape (CAM13) harbored serum antibodies that cross-reacted strongly with HIV-1 antigens; all other apes were seronegative. To characterize the newly identified virus, 14 partially overlapping viral fragments were amplified from fecal virion RNA and concatenated to yield a complete SIVcpz genome (9,284 bp). Phylogenetic analyses revealed that SIVcpzCAM13 fell well within the radiation of the SIVcpzPtt group of viruses, as part of a clade including all other SIVcpzPtt strains as well as HIV-1 groups M and N. However, SIVcpzCAM13 clustered most closely with SIVcpzGAB1 from Gabon rather than with SIVcpzCAM3 and SIVcpzCAM5 from Cameroon, indicating the existence of divergent SIVcpzPtt lineages within the same geographic region. These data, together with evidence of recombination among ancestral SIVcpzPtt lineages, indicate long-standing endemic infection of central chimpanzees and reaffirm a west central African origin of HIV-1. Whether P. t. vellerosus apes are naturally infected with SIVcpz requires further study
Vienna Circle and Logical Analysis of Relativity Theory
In this paper we present some of our school's results in the area of building
up relativity theory (RT) as a hierarchy of theories in the sense of logic. We
use plain first-order logic (FOL) as in the foundation of mathematics (FOM) and
we build on experience gained in FOM.
The main aims of our school are the following: We want to base the theory on
simple, unambiguous axioms with clear meanings. It should be absolutely
understandable for any reader what the axioms say and the reader can decide
about each axiom whether he likes it. The theory should be built up from these
axioms in a straightforward, logical manner. We want to provide an analysis of
the logical structure of the theory. We investigate which axioms are needed for
which predictions of RT. We want to make RT more transparent logically, easier
to understand, easier to change, modular, and easier to teach. We want to
obtain deeper understanding of RT.
Our work can be considered as a case-study showing that the Vienna Circle's
(VC) approach to doing science is workable and fruitful when performed with
using the insights and tools of mathematical logic acquired since its formation
years at the very time of the VC activity. We think that logical positivism was
based on the insight and anticipation of what mathematical logic is capable
when elaborated to some depth. Logical positivism, in great part represented by
VC, influenced and took part in the birth of modern mathematical logic. The
members of VC were brave forerunners and pioneers.Comment: 25 pages, 1 firgure
CARMA Large Area Star Formation Survey: Observational Analysis of Filaments in the Serpens South Molecular Cloud
We present the N2H+(J=1-0) map of the Serpens South molecular cloud obtained
as part of the CARMA Large Area Star Formation Survey (CLASSy). The
observations cover 250 square arcminutes and fully sample structures from 3000
AU to 3 pc with a velocity resolution of 0.16 km/s, and they can be used to
constrain the origin and evolution of molecular cloud filaments. The spatial
distribution of the N2H+ emission is characterized by long filaments that
resemble those observed in the dust continuum emission by Herschel. However,
the gas filaments are typically narrower such that, in some cases, two or three
quasi-parallel N2H+ filaments comprise a single observed dust continuum
filament. The difference between the dust and gas filament widths casts doubt
on Herschel ability to resolve the Serpens South filaments. Some molecular
filaments show velocity gradients along their major axis, and two are
characterized by a steep velocity gradient in the direction perpendicular to
the filament axis. The observed velocity gradient along one of these filaments
was previously postulated as evidence for mass infall toward the central
cluster, but these kind of gradients can be interpreted as projection of
large-scale turbulence.Comment: 12 pages, 4 figures, published in ApJL (July 2014
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