579 research outputs found
Bose-Einstein Condensation in a CO_2-laser Optical Dipole Trap
We report on the achieving of Bose-Einstein condensation of a dilute atomic
gas based on trapping atoms in tightly confining CO_2-laser dipole potentials.
Quantum degeneracy of rubidium atoms is reached by direct evaporative cooling
in both crossed and single beam trapping geometries. At the heart of these
all-optical condensation experiments is the ability to obtain high initial
atomic densities in quasistatic dipole traps by laser cooling techniques.
Finally, we demonstrate the formation of a condensate in a field insensitive
m_F=0 spin projection only. This suppresses fluctuations of the chemical
potential from stray magnetic fields.Comment: 8 pages, 5 figure
Multiple micro-optical atom traps with a spherically aberrated laser beam
We report on the loading of atoms contained in a magneto-optic trap into
multiple optical traps formed within the focused beam of a CO_{2} laser. We
show that under certain circumstances it is possible to create a linear array
of dipole traps with well separated maxima. This is achieved by focusing the
laser beam through lenses uncorrected for spherical aberration. We demonstrate
that the separation between the micro-traps can be varied, a property which may
be useful in experiments which require the creation of entanglement between
atoms in different micro-traps. We suggest other experiments where an array of
these traps could be useful.Comment: 10 pages, 3 figure
All-Optical Production of a Degenerate Fermi Gas
We achieve degeneracy in a mixture of the two lowest hyperfine states of
Li by direct evaporation in a CO laser trap, yielding the first
all-optically produced degenerate Fermi gas. More than atoms are
confined at temperatures below K at full trap depth, where the Fermi
temperature for each state is K. This degenerate two-component mixture
is ideal for exploring mechanisms of superconductivity ranging from Cooper
pairing to Bose condensation of strongly bound pairs.Comment: 4 pgs RevTeX with 2 eps figs, to be published in Phys. Rev. Let
Entanglement of atoms via cold controlled collisions
We show that by using cold controlled collisions between two atoms one can
achieve conditional dynamics in moving trap potentials. We discuss implementing
two qubit quantum--gates and efficient creation of highly entangled states of
many atoms in optical lattices.Comment: 4 pages 3 figure
Spinor Bosonic Atoms in Optical Lattices: Symmetry Breaking and Fractionalization
We study superfluid and Mott insulator phases of cold spin-1 Bose atoms with
antiferromagnetic interactions in an optical lattice, including a usual polar
condensate phase, a condensate of singlet pairs, a crystal spin nematic phase,
and a spin singlet crystal phase. We suggest a possibility of exotic
fractionalized phases of spinor BEC and discuss them in the language of
topological defect condensation and lattice gauge theory.Comment: 4 pages, 1 figure included; references adde
Resolved-sideband Raman cooling to the ground state of an optical lattice
We trap neutral Cs atoms in a two-dimensional optical lattice and cool them
close to the zero-point of motion by resolved-sideband Raman cooling. Sideband
cooling occurs via transitions between the vibrational manifolds associated
with a pair of magnetic sublevels and the required Raman coupling is provided
by the lattice potential itself. We obtain mean vibrational excitations
\bar{n}_x \approx \bar{n}_y \approx 0.01, corresponding to a population \sim
98% in the vibrational ground state. Atoms in the ground state of an optical
lattice provide a new system in which to explore quantum state control and
subrecoil laser coolingComment: PDF file, 13 pages including 3 figure
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors
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