2,086 research outputs found
Utility of serological markers in inflammatory bowel diseases: Gadget or magic?
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely investigated, an increasing amount of experimental data is available on newly discovered antibodies directed against various microbial antigens. The role of the assessment of various antibodies in the current IBD diagnostic algorithm is often questionable due to their limited sensitivity. In contrast, the association of serologic markers with disease behavior and phenotype is becoming increasingly well-established. An increasing number of observations confirms that patients with Crohn's disease expressing multiple serologic markers at high titers are more likely to have complicated small bowel disease (e.g. stricture and/or perforation) and are at higher risk for surgery than those without, or with low titers of antibodies. Creating homogenous disease sub-groups based on serologic response may help develop more standardized therapeutic approaches and may help in a better understanding of the pathomechanism of IBD. Further prospective clinical studies are needed to establish the clinical role of serologic tests in IBD
Stochastic self-assembly of incommensurate clusters
We examine the classic problem of homogeneous nucleation and growth by
deriving and analyzing a fully discrete stochastic master equation. Upon
comparison with results obtained from the corresponding mean-field
Becker-D\"{o}ring equations we find striking differences between the two
corresponding equilibrium mean cluster concentrations. These discrepancies
depend primarily on the divisibility of the total available mass by the maximum
allowed cluster size, and the remainder. When such mass incommensurability
arises, a single remainder particle can "emulsify" or "disperse" the system by
significantly broadening the mean cluster size distribution. This finite-sized
broadening effect is periodic in the total mass of the system and can arise
even when the system size is asymptotically large, provided the ratio of the
total mass to the maximum cluster size is finite. For such finite ratios we
show that homogeneous nucleation in the limit of large, closed systems is not
accurately described by classical mean-field mass-action approaches.Comment: 5 pages, 4 figures, 1 tabl
Mean First Passage Time in Periodic Attractors
The properties of the mean first passage time in a system characterized by
multiple periodic attractors are studied. Using a transformation from a high
dimensional space to 1D, the problem is reduced to a stochastic process along
the path from the fixed point attractor to a saddle point located between two
neighboring attractors. It is found that the time to switch between attractors
depends on the effective size of the attractors, , the noise, ,
and the potential difference between the attractor and an adjacent saddle point
as: ; the
ratio between the sizes of the two attractors affects . The
result is obtained analytically for small and confirmed by numerical
simulations. Possible implications that may arise from the model and results
are discussed.Comment: 14 pages, 3 figures, submitted to journal of physics
Influence of breakage on crystal size distribution in a continuous cooling crystallizer
A detailed two-dimensional population balance model of continuous cooling crystallization, involving nucleation, growth of the two characteristic crystal facets and binary breakage along the length of needle-shape crystals is presented and analysed. The population balance equation is reduced into a moment equation model of the joint moments of crystal size variables. The dynamic behaviour of the crystallizer and the effects of kinetic and process parameters on the characteristics of crystal size distribution are studied by simulation. The observations and analysis have revealed that there exist strong interactions between the breakage and the product properties
Punitive Damages Under the Federal Arbitration Act: Have Arbitrators\u27 Remedial Powers Been Circumscribed by State Law?
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