Giant nonlinear conduction and thyristor-like negative derivative resistance in BaIrO3 single crystals

We synthesized single-crystalline samples of monoclinic BaIrO3 using a molten flux method, and measured their magnetization, resistivity, Seebeck coefficient and nonlinear voltage-current characteristics. The magnetization rapidly increases below a ferromagnetic transition temperature TC of 180 K, where the resistivity concomitantly shows a hump-type anomaly, followed by a sharp increase below 30 K. The Seebeck coefficient suddenly increases below TC, and shows linear temperature dependence below 50 K. A most striking feature of this compound is that the anomalously giant nonlinear conduction is observed below 30 K, where a small current density of 20 A/cm2 dramatically suppresses the sharp increase in resistivity to induce a metallic conduction down to 4 K.Comment: 10 pages, 4 figures Submitted to Physical Review Letter

The effects of intrathecal midazolam on the duration of analgesia in patients undergoing knee arthroscopy

Background: Spinal anaesthesia is a common anaesthetic technique for lower limb surgery. Many adjuvants have been tried to prolong the duration of analgesia provided by local anaesthetics when administered intrathecally. Midazolam has been shown to prolong the duration of analgesia when used as an adjuvant, providing the added advantages of mild sedation and amnesia, while being devoid of neurotoxicity, and the adverse effects of opioids. This study was designed to evaluate the effect of 2 mg preservative-free intrathecal midazolam added to spinal bupivacaine during postoperative analgesia, and the incidence of adverse effects, if any, in patients undergoing knee arthroscopies. Method: Fifty consenting American Society of Anesthesiologists (ASA) physical status I or II patients of either gender (men = 19, women = 31), aged between 18-56 years, were randomly allocated to two groups (25 each). Group M received 0.5% hyperbaric bupivacaine with preservative-free midazolam 2 mg intrathecally, and Group S received 0.5% hyperbaric bupivacaine with saline intrathecally. Peak sensory level, total duration of analgesia, duration of motor blockade, pain score using the Visual Analogue Scale, and sedation score using the Observer Assessment Score of Sedation were assessed, along with vital parameters, namely heart rate and systolic, diastolic and mean blood pressure. Results: The total duration of analgesia observed was significantly higher in Group M (399 ± 88.11 minutes) vs. Group S (301.60 ± 110.14 minutes), and the pain score was lower in Group M (33.6 ± 4.68 mm) vs. Group S (56.6 ± 8.64 mm). Conclusion: The addition of preservative-free midazolam 2 mg to intrathecal 0.5% hyperbaric bupivacaine prolongs the duration of analgesia without any observed adverse effects in patients undergoing knee arthroscopies.Keywords: intrathecal midazolam, spinal anaesthesi

EFFECT OF ADVERTISED POLYHERBAL (AYURVEDIC) APHRODISIAC FORMULATIONS ON POTENT MALE ALBINO RATS

Objective: The objective of the study was to study aphrodisiac activity of polyherbals on albino Wistar rats. Methods: Play Win and Ayurex are examples of the already marketed polyherbal formulations (PHFs), which are used in this study to determine their mating behavior and mating performance test activities in albino Wistar rats. Results: Both the test drugs Play Win and Ayurex created noteworthy increase in the mounting behavior of animals. It was also observed that mounting behavior activity (number of mounts) in Play Win, in the 1st h and the 3rd h, was greater than Ayurex. Administration of suspension of a single dose of Play Win, Ayurex, and sildenafil citrate concluded in the increase in the mating performance of the rats. The result of Play Win was found to be less than that of Ayurex and nearly the same as that of sildenafil citrate. Conclusion: From the research of the above-mentioned formulations with comparison to the standard drug (sildenafil), it is concluded that the PHFs are capable of producing aphrodisiac activity

SYNTHESIS OF QUINOLINYL-OXADIAZOLE AS A POTENT ANTIBACTERIAL AGENT AND SA-FABI INHIBITOR

Objective: Microbial resistance to currently marketed drugs is a serious problem worldwide and there is a vital need to develop novel antibiotics. Enoyl-ACP reductase (FabI) is essential for fatty acid biosynthesis and hence serves as an appealing target for antibacterials against methicillin resistant S. aureus. The present study focuses on the synthesis, antibacterial and saFab1 docking studies of three new series of quinoline derivatives: 5-[(quinolin-8-yloxy) methyl]-1,3,4-oxadiazole-2(3H)-thiones, N-(2,5-dimethyl-1H-pyrrol-1-yl)-2oxyacetamides and 2-(oxyacetyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-ones with integrated ether linkages.Methods: Three different substituted hydrazides were synthesized from substituted quinolinols. These hydrazides were allowed to undergo further reactions with carbon disulphide, 2,5-hexanedione and ethyl acetoacetate respectively to prepare 1,3,4-oxadiazole-2-thiones, N-substituted pyrrole acetamides and pyrazol-3-ones. The synthesized hydrazide derivatives were subjected to antimicrobial studies against Staphylococcus aureus. Docking studies were carried out using enoyl-ACP reductase crystal structure complexed with NADPH.Results: 5-{[(2-methylquinolin-8-yl) oxy] methyl}-1, 3, 4-oxadiazole-2(3H)-thione (2b) with a methyl substituent on the quinoline ring was found to display significant antibacterial potential against S. aureus. Good binding interactions were observed in subsequent docking studies via formation of Fab1-NAD+-2b ternary complex through hydrogen bonding and stacking interactions.Conclusion: 1, 3, 4-oxadiazole-2(3H)-thione (2b) was found to exhibit promising antibacterial potential against S. aureus.Â

Theory of the optical properties of non-absorbing compensated cholesteric liquid crystals

A theory is developed of the optical properties of a non-absorbing compensated cholesteric liquid crystal. It is shown that the Mauguin-de Vries equation fails when the pitch becomes very large. Theoretical curves are presented of the dependence of the rotatory power on pitch for different values of the sample thickness. The results are in agreement with the observed variation of the rotatory power of a compensated cholesteric mixture with temperature

Genetic and Neuroanatomical Support for Functional Brain Network Dynamics in Epilepsy

Focal epilepsy is a devastating neurological disorder that affects an overwhelming number of patients worldwide, many of whom prove resistant to medication. The efficacy of current innovative technologies for the treatment of these patients has been stalled by the lack of accurate and effective methods to fuse multimodal neuroimaging data to map anatomical targets driving seizure dynamics. Here we propose a parsimonious model that explains how large-scale anatomical networks and shared genetic constraints shape inter-regional communication in focal epilepsy. In extensive ECoG recordings acquired from a group of patients with medically refractory focal-onset epilepsy, we find that ictal and preictal functional brain network dynamics can be accurately predicted from features of brain anatomy and geometry, patterns of white matter connectivity, and constraints complicit in patterns of gene coexpression, all of which are conserved across healthy adult populations. Moreover, we uncover evidence that markers of non-conserved architecture, potentially driven by idiosyncratic pathology of single subjects, are most prevalent in high frequency ictal dynamics and low frequency preictal dynamics. Finally, we find that ictal dynamics are better predicted by white matter features and more poorly predicted by geometry and genetic constraints than preictal dynamics, suggesting that the functional brain network dynamics manifest in seizures rely on - and may directly propagate along - underlying white matter structure that is largely conserved across humans. Broadly, our work offers insights into the generic architectural principles of the human brain that impact seizure dynamics, and could be extended to further our understanding, models, and predictions of subject-level pathology and response to intervention

Thermomechanical effect in cholesteric liquid crystals

We discuss some possible experimental geometries for studying Leslie's thermomechanical effect in cholesteric liquid crystals. The discussion includes the effect of a temperature gradient (i) along and (ii) perpendicular to the helical axis. The feasibility of observing the effect and of extracting the thermomechanical coefficients is examined

Perancangan Pusat Informasi Adat Dan Budaya Sabu-Raijua : Transformasi Kampung Adat

Setiap daerah dan suku yang berdia, di Indonesia memiliki kearifam local yang berbeda-beda. Nusa Tenggara Timur merupakan salah satu kepulauan yang kayak suku dan budaya. Salah satu Suku besar di Pulau ini adalah Suku Sabu. Suku Sabu memiliki keunikan dari segi kultur dan budaya. Hal ini tidak hanya tercermin dalam seni namun telah menjadi cara hidup. Masyarakat Sabu memiliki pola permukiman dan cara hidup yang khas. Mereka adalah para pelaut ulung sehingga diimplementasikan dalam caranya bermukim dan membangun permukiman atau kampung Adat. Pulau Sabu –Raijua juga telah menjadi salah satu daya tarik bagi wisatawan mancanegara.Selain itu banyak masyarakat Sabu yang telah keluar dan merantau di tanah lain sehingga seringkali mereka tidak mendapatkan informasi tentang adat dan budaya Sabu. Dengan banyaknya wisatawan baik dari dalam dan luar negeri yang datang dan menurunnya kesadaran memiliki dan bangga akan budaya sendiri maka diperlukanlah perencanaan Pusat Informasi Adat dan Budaya masyarakat Sabu-Raijua.Perencaan Pusat Informasi Adat dan Budaya beridentitas kearifan local sehingga digunakan metode transformasi. Perancangan ini mentrasformasi penataan, bentukan fisik dan tampilang dari Kampung Adat yang biasa disebut “Rae Kowa” atau Kampung Perahu

Morintides: cargo-free chitin-binding peptides from Moringa oleifera

Statistics of the structure of mO1 generated by CNSsolve 1.3. (DOCX 16 kb