Bayesian stroke modeling details sex biases in the white matter substrates of aphasia

Ischemic cerebrovascular events often lead to aphasia. Previous work provided hints that such strokes may affect women and men in distinct ways. Women tend to suffer strokes with more disabling language impairment, even if the lesion size is comparable to men. In 1,401 patients, we isolated data-led representations of anatomical lesion patterns and hand-tailored a Bayesian analytical solution to carefully model the degree of sex divergence in predicting language outcomes ∼3 months after stroke. We located lesion-outcome effects in the left-dominant language network that highlight the ventral pathway as a core lesion focus across different tests of language performance. We provide newly detailed evidence for sex-specific brain-behavior associations in the domain-general networks associated with cortico-subcortical pathways, with unique contributions of the fornix in women and cingular fiber bundles in men. Our collective findings suggest diverging white matter substrates in how stroke causes language deficits in women and men. Clinically acknowledging such sex disparities has the potential to improve personalized treatment for stroke patients worldwide

Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery

OBJECTIVE Decision-making for intracranial tumor surgery requires balancing the oncological benefit against the risk for resection-related impairment. Risk estimates are commonly based on subjective experience and generalized num-bers from the literature, but even experienced surgeons overestimate functional outcome after surgery. Today, there is no reliable and objective way to preoperatively predict an individual patient's risk of experiencing any functional impair-ment. METHODS The authors developed a prediction model for functional impairment at 3 to 6 months after microsurgical resection, defined as a decrease in Karnofsky Performance Status of >= 10 points. Two prospective registries in Swit- zerland and Italy were used for development. External validation was performed in 7 cohorts from Sweden, Norway, Germany, Austria, and the Netherlands. Age, sex, prior surgery, tumor histology and maximum diameter, expected major brain vessel or cranial nerve manipulation, resection in eloquent areas and the posterior fossa, and surgical approach were recorded. Discrimination and calibration metrics were evaluated. RESULTS In the development (2437 patients, 48.2% male; mean age +/- SD: 55 +/- 15 years) and external validation (2427 patients, 42.4% male; mean age +/- SD: 58 +/- 13 years) cohorts, functional impairment rates were 21.5% and 28.5%, respectively. In the development cohort, area under the curve (AUC) values of 0.72 (95% CI 0.69-0.74) were observed. In the pooled external validation cohort, the AUC was 0.72 (95% CI 0.69-0.74), confirming generalizability. Calibration plots indicated fair calibration in both cohorts. The tool has been incorporated into a web-based application available at https://neurosurgery.shinyapps.io/impairment/. CONCLUSIONS Functional impairment after intracranial tumor surgery remains extraordinarily difficult to predict, al- though machine learning can help quantify risk. This externally validated prediction tool can serve as the basis for case by-case discussions and risk-to-benefit estimation of surgical treatment in the individual patient.Scientific Assessment and Innovation in Neurosurgical Treatment Strategie

Histopathologische Befunde bei therapierter und nichttherapierter SARS-CoV-2-Infektion – Bericht über 3 Autopsien

Zusammenfassung Bei letalem Verlauf einer SARS-CoV-2-Infektion kommt nach bisherigem Kenntnisstand eine Beteiligung mehrerer innerer Organe in Betracht. Im Vordergrund stehen pathologische Befunde im Lungengewebe, berichtet wird aber auch von direkt oder indirekt als Folge einer Infektion mit SARS-CoV‑2 auftretenden (histo-)pathologischen Befunden im Nierengewebe, in der Leber und im Myokard. Der Vergleich der histopathologischen Diagnostik mit konventionell-histologischen Färbungen bei 3 im Zusammenhang mit einer SARS-CoV-2-Infektion verstorbenen Männern zeigt teils identische Befunde und erlaubt Überlegungen zu Chronologie und Pathophysiologie des Krankheitsverlaufes. Zwei Männer wurden intensivmedizinisch invasiv beatmet; ein Mann starb nach 8 Tagen häuslicher Quarantäne ohne Therapie. Es zeigt sich ein großes Spektrum SARS-CoV-2-assoziierter Befunde