Microlensing of Lensed Supernovae

Given the number of recently discovered galaxy-galaxy lens systems, we anticipate that a gravitationally lensed supernova will be observed within the next few years. We explore the possibility that stars in the lens galaxy will produce observable microlensing fluctuations in lensed supernova light curves. For typical parameters, we predict that ~70% of lensed SNe will show microlensing fluctuations > 0.5 mag, while ~25% will have fluctuations > 1 mag. Thus microlensing of lensed supernova will be both ubiquitous and observable. Additionally, we show that microlensing fluctuations will complicate measurements of time delays from multiply imaged supernovae: time delays accurate to better than a few days will be difficult to obtain. We also consider prospects for extracting the lens galaxy's stellar mass fraction and mass function from microlensing fluctuations via a new statistical measure, the time-weighted light curve derivative.Comment: 13 pages, emulateapj format; accepted in ApJ; expanded discussion of time delay uncertaintie

How can we test seesaw experimentally?

The seesaw mechanism for the small neutrino mass has been a popular paradigm, yet it has been believed that there is no way to test it experimentally. We present a conceivable outcome from future experiments that would convince us of the seesaw mechanism. It would involve a variety of data from LHC, ILC, cosmology, underground, and low-energy flavor violation experiments to establish the case.Comment: 5 pages, 4 figure

Service life evaluation of rigid explosive transfer lines

This paper describes a joint Army/NASA-sponsored research program on the service life evaluation of rigid explosive transfer lines. These transfer lines are used to initiate emergency crew escape functions on a wide variety of military and NASA aircraft. The purpose of this program was to determine quantitatively the effects of service, age, and degradation on rigid explosive transfer lines to allow responsible, conservative, service life determination. More than 800 transfer lines were removed from the U.S. Army AH-1G and AH-1S, the U.S. Air Force B-1 and F-111, and the U.S. Navy F-14 aircraft for testing. The results indicated that the lines were not adversely affected by age, service, or a repeat of the thermal qualification tests on full-service lines. Extension of the service life of rigid explosive transfer lines should be considered, since considerable cost savings could be realized with no measurable decrease in system reliability

Grid computing in image analysis

Diagnostic surgical pathology or tissue–based diagnosis still remains the most reliable and specific diagnostic medical procedure. The development of whole slide scanners permits the creation of virtual slides and to work on so-called virtual microscopes. In addition to interactive work on virtual slides approaches have been reported that introduce automated virtual microscopy, which is composed of several tools focusing on quite different tasks. These include evaluation of image quality and image standardization, analysis of potential useful thresholds for object detection and identification (segmentation), dynamic segmentation procedures, adjustable magnification to optimize feature extraction, and texture analysis including image transformation and evaluation of elementary primitives

Interactive and automated application of virtual microscopy

Virtual microscopy can be applied in an interactive and an automated manner. Interactive application is performed in close association to conventional microscopy. It includes image standardization suitable to the performance of an individual pathologist such as image colorization, white color balance, or individual adjusted brightness. The steering commands have to include selection of wanted magnification, easy navigation, notification, and simple measurements (distances, areas). The display of the histological image should be adjusted to the physical limits of the human eye, which are determined by a view angle of approximately 35 seconds. A more sophisticated performance should include acoustic commands that replace the corresponding visual commands. Automated virtual microscopy includes so-called microscopy assistants which can be defined similar to the developed assistants in computer based editing systems (Microsoft Word, etc.). These include an automated image standardization and correction algorithms that excludes images of poor quality (for example uni-colored or out-of-focus images), an automated selection of the most appropriate field of view, an automated selection of the best magnification, and finally proposals of the most probable diagnosis. A quality control of the final diagnosis, and feedback to the laboratory determine the proposed system. The already developed tools of such a system are described in detail, as well as the results of first trials. In order to enhance the speed of such a system, and to allow further user-independent development a distributed implementation probably based upon Grid technology seems to be appropriate. The advantages of such a system as well as the present pathology environment and its expectations will be discussed in detail

Neutralino Pair Production and 3-Body Decays at e+e−e^+e^- Linear Colliders as Probes of CP Violation in the Neutralino System

In the CP-invariant supersymmetric theories, the steep S-wave (slow P-wave) rise of the cross section for any non-diagonal neutralino pair production in $e^+ e^-$ annihilation, $e^+e^- \to \tilde{\chi}^0_i \tilde{\chi}^0_j$ ($i \neq j$), near threshold is accompanied by the slow P-wave (steep S-wave) decrease of the fermion invariant mass distribution of the 3-body neutralino decay, $\tilde{\chi}^0_i \to \tilde{\chi}^0_j f\bar{f}$ ($f=l$ or $q$), near the end point. These selection rules, unique to the neutralino system due to its Majorana nature, guarantee that the observation of simultaneous sharp S-wave excitations of the production cross section near threshold and the lepton and quark invariant mass distribution near the end point is a qualitative, unambiguous evidence for CP violation in the neutralino system.Comment: 11 pages, 1 eps figure, a reference adde

Virtual slides in peer reviewed, open access medical publication

<p>Abstract</p> <p>Background</p> <p>Application of virtual slides (VS), the digitalization of complete glass slides, is in its infancy to be implemented in routine diagnostic surgical pathology and to issues that are related to tissue-based diagnosis, such as education and scientific publication.</p> <p>Approach</p> <p>Electronic publication in Pathology offers new features of scientific communication in pathology that cannot be obtained by conventional paper based journals. Most of these features are based upon completely open or partly directed interaction between the reader and the system that distributes the article. One of these interactions can be applied to microscopic images allowing the reader to navigate and magnify the presented images. VS and interactive Virtual Microscopy (VM) are a tool to increase the scientific value of microscopic images.</p> <p>Technology and Performance</p> <p>The open access journal Diagnostic Pathology <url>http://www.diagnosticpathology.org</url> has existed for about five years. It is a peer reviewed journal that publishes all types of scientific contributions, including original scientific work, case reports and review articles. In addition to digitized still images the authors of appropriate articles are requested to submit the underlying glass slides to an institution (DiagnomX.eu, and Leica.com) for digitalization and documentation. The images are stored in a separate image data bank which is adequately linked to the article. The normal review process is not involved. Both processes (peer review and VS acquisition) are performed contemporaneously in order to minimize a potential publication delay. VS are not provided with a DOI index (digital object identifier). The first articles that include VS were published in March 2011.</p> <p>Results and Perspectives</p> <p>Several logistic constraints had to be overcome until the first articles including VS could be published. Step by step an automated acquisition and distribution system had to be implemented to the corresponding article. The acceptance of VS by the reader is high as well as by the authors. Of specific value are the increased confidence to and reputation of authors as well as the presented information to the reader. Additional associated functions such as access to author-owned related image collections, reader-controlled automated image measurements and image transformations are in preparation.</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1232133347629819</url>.</p

Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer

Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers. Methods: Sections of paraffin-embedded histological material of 481 lungs from lung tumor patients following radical lung excision processed by a routine immunohistochemical method (avidin-biotin labeling, DAB chromogen). Specific antibodies against galectins-1 and - 3 and the heparin-binding lectin were tested. Staining by labeled galectins and hyaluronic acid was similarly visualized by a routine protocol. After semiquantitative assessment of staining, the results were compared with the pT and pN stages and the histological type. Survival was calculated by univariate and multivariate methods. Results: Binding of galectin-1 and its expression tended to increase, whereas the parameters for galectin-3 decreased in advanced pT and pN stages at a statistically significant level. The number of positive cases was considerably smaller among the cases with small cell lung cancer than in the group with non-small-cell lung cancer, among which adenocarcinomas figured prominently with the exception of galectin-1 expression. Kaplan-Meier computations revealed that the survival rate of patients with galectin-3-binding or galectin-1-expressing tumors was significantly poorer than that of the negative cases. In the multivariate calculations of survival lymph node metastases ( p < 0.0001), histological type ( p = 0.003), galectin-3-binding capacity ( p = 0.01), galectin-3 expression ( p = 0.03) and pT status ( p = 0.003) proved to be independent prognostic factors, not correlated with the pN stage. Conclusion: The expression and the capacity to bind the adhesion/growth regulatory galectin-3 is defined as an unfavorable prognostic factor not correlated with the pTN stage. Copyright (C) 2005 S. Karger AG, Basel

Bounds on gamma from CP violation measurements in B -> pi+ pi- and B -> psi K_S

We study the determination of gamma from CP-violating observables in B -> pi+ pi- and B -> psi K_S. This determination requires theoretical input to one combination of hadronic parameters. We show that a mild assumption about this quantity may allow bounds to be placed on gamma, but we stress the pernicious effects that an eightfold discrete ambiguity has on such an analysis. The bounds are discussed as a function of the direct (C) and interference (S) CP-violating observables obtained from time-dependent B -> pi+ pi- decays, and their behavior in the presence of new physics effects in B-Bbar mixing is studied. (V2: Misprints corrected. Slightly improved discussion.)Comment: 11 pages, RevTex 4, 5 eps figures include

Seeing Star Formation Regions with Gravitational Microlensing

We qualitatively study the effects of gravitational microlensing on our view of unresolved extragalactic star formation regions. Using a general gravitational microlensing configuration, we perform a number of simulations that reveal that specific imprints of the star forming region are imprinted, both photometrically and spectroscopically, upon observations. Such observations have the potential to reveal the nature and size of these star forming regions, through the degree of variability observed in a monitoring campaign, and hence resolve the star formation regions in distant galaxies which are too small to be probed via more standard techniques.Comment: 7 pages, 8 figures, ApJ accepte