1,322 research outputs found
Molecular Dipolar Crystals as High Fidelity Quantum Memory for Hybrid Quantum Computing
We study collective excitations of rotational and spin states of an ensemble
of polar molecules, which are prepared in a dipolar crystalline phase, as a
candidate for a high fidelity quantum memory. While dipolar crystals are formed
in the high density limit of cold clouds of polar molecules under 1D and 2D
trapping conditions, the crystalline structure protects the molecular qubits
from detrimental effects of short range collisions. We calculate the lifetime
of the quantum memory by identifying the dominant decoherence mechanisms, and
estimate their effects on gate operations, when a molecular ensemble qubit is
transferred to a superconducting strip line cavity (circuit QED). In the case
rotational excitations coupled by dipole-dipole interactions we identify
phonons as the main limitation of the life time of qubits. We study specific
setups and conditions, where the coupling to the phonon modes is minimized.
Detailed results are presented for a 1D dipolar chain
Fractoluminescence characterization of the energy dissipated during fast fracture of glass
Fractoluminescence experiments are performed on two kinds of silicate
glasses. All the light spectra collected during dynamic fracture reveal a black
body radiator behaviour, which is interpreted as a crack velocity-dependent
temperature rise close to the crack tip. Crack velocities are estimated to be
of the order of 1300 m.s and fracture process zones are shown to extend
over a few nanometers.Comment: Accepted for publication in Europhysics Letters; 5 pages; 4 figure
Mesenchymal stem cells with increased stromal cell-derived factor 1 expression enhanced fracture healing
Treatment of critical size bone defects pose a challenge in orthopedics. Stem cell therapy together with cytokines has the potential to improve bone repair as they cause the migration and homing of stem cells to the defect site. However, the engraftment, participation, and recruitment of other cells within the regenerating tissue are important. To enhance stem cell involvement, this study investigated overexpression of stem cells with stromal cell-derived factor 1 (SDF-1) using an adenovirus. We hypothesized that these engineered cells would effectively increase the migration of native cells to the site of fracture, enhancing bone repair. Before implantation, we showed that SDF-1 secreted by transfected cells increased the migration of nontransfected cells. In a rat defect bone model, bone marrow mesenchymal stem cells overexpressing SDF-1 showed significantly (p=0.003) more new bone formation within the gap and less bone mineral loss at the area adjacent to the defect site during the early bone healing stage. In conclusion, SDF-1 was shown to play an important role in accelerating fracture repair and contributing to bone repair in rat models, by recruiting more host stem cells to the defect site and encouraging osteogenic differentiation and production of bone
A NWB-based dataset and processing pipeline of human single-neuron activity during a declarative memory task
A challenge for data sharing in systems neuroscience is the multitude of different data formats used. Neurodata Without Borders: Neurophysiology 2.0 (NWB:N) has emerged as a standardized data format for the storage of cellular-level data together with meta-data, stimulus information, and behavior. A key next step to facilitate NWB:N adoption is to provide easy to use processing pipelines to import/export data from/to NWB:N. Here, we present a NWB-formatted dataset of 1863 single neurons recorded from the medial temporal lobes of 59 human subjects undergoing intracranial monitoring while they performed a recognition memory task. We provide code to analyze and export/import stimuli, behavior, and electrophysiological recordings to/from NWB in both MATLAB and Python. The data files are NWB:N compliant, which affords interoperability between programming languages and operating systems. This combined data and code release is a case study for how to utilize NWB:N for human single-neuron recordings and enables easy re-use of this hard-to-obtain data for both teaching and research on the mechanisms of human memory
Retaining Expression on De-identified Faces
© Springer International Publishing AG 2017The extensive use of video surveillance along with advances in face recognition has ignited concerns about the privacy of the people identifiable in the recorded documents. A face de-identification algorithm, named k-Same, has been proposed by prior research and guarantees to thwart face recognition software. However, like many previous attempts in face de-identification, kSame fails to preserve the utility such as gender and expression of the original data. To overcome this, a new algorithm is proposed here to preserve data utility as well as protect privacy. In terms of utility preservation, this new algorithm is capable of preserving not only the category of the facial expression (e.g., happy or sad) but also the intensity of the expression. This new algorithm for face de-identification possesses a great potential especially with real-world images and videos as each facial expression in real life is a continuous motion consisting of images of the same expression with various degrees of intensity.Peer reviewe
Osteoporosis and ageing affects the migration of stem cells and this is ameliorated by transfection with CXCR4
OBJECTIVES: Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derived factor 1(SDF-1) and its receptor chemokine receptor type 4 (CXCR4) play important roles in maintaining mobilisation, trafficking and homing of stem cells from bone marrow to the site of injury. We investigated the differences in migration of MSCs from the femurs of young, adult and ovariectomised (OVX) rats and the effect of CXCR4 over-expression on their migration. METHODS: MSCs from young, adult and OVX rats were put in a Boyden chamber to establish their migration towards SDF-1. This was compared with MSCs transfected with CXCR4, as well as MSCs differentiated to osteoblasts. RESULTS: MSCs from OVX rats migrate significantly (p < 0.05) less towards SDF-1 (9%, sd 5%) compared with MSCs from adult (15%, sd 3%) and young rats (25%, sd 4%). Cells transfected with CXCR4 migrated significantly more towards SDF-1 compared with non-transfected cells, irrespective of whether these cells were from OVX (26.5%, sd 4%), young (47%, sd 17%) or adult (21%, sd 4%) rats. Transfected MSCs differentiated to osteoblasts express CXCR4 but do not migrate towards SDF-1. CONCLUSIONS: MSC migration is impaired by age and osteoporosis in rats, and this may be associated with a significant reduction in bone formation in osteoporotic patients. The migration of stem cells can be ameliorated by upregulating CXCR4 levels which could possibly enhance fracture healing in osteoporotic patients
Quantum Simulations of Extended Hubbard Models with Dipolar Crystals
In this paper we study the realization of lattice models in mixtures of
atomic and dipolar molecular quantum gases. We consider a situation where polar
molecules form a self-assembled dipolar lattice, in which atoms or molecules of
a second species can move and scatter. We describe the system dynamics in a
master equation approach in the Brownian motion limit of slow particles and
fast phonons, which we find appropriate for our system. In a wide regime of
parameters, the reduced dynamics of the particles leads to physical
realizations of extended Hubbard models with tuneable long-range interactions
mediated by crystal phonons. This extends the notion of quantum simulation of
strongly correlated systems with cold atoms and molecules to include
phonon-dynamics, where all coupling parameters can be controlled by external
fields.Comment: 44 pages, 14 figure
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