Surrogate-Assisted Artificial Immune Systems for Expensive Optimization Problems

Non

Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks

Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types

Navigating a river by its bends. A study on transnational social networks as resources for the transformation of Cambodia

This article explores in what ways first generation Cambodian French and Cambodian American returnees create and employ the social capital available in their transnational social networks upon their return to Cambodia. The triangular interdependence between the returnees, their overseas immigrant communities and homeland society is taken as a starting point. The central argument is that Cambodian French and Cambodian American returnees build different relationships to Cambodia due to: (1) the influence of their immigrant communities in the countries of resettlement; and (2) the contexts of their exit from Cambodia. Regarding debates on the contribution of returnees to an emergent nation, findings in this multisited casestudy bring forward that ideas of return held by the three parties involved may force remigrants into transnationalism in both host and home countries. Findings also demonstrate that social capital may be seen as a resource or a restraint in the lives of returnees

Electronic structure of atomic hydrogen at anion sites in KCl

SIGLEAvailable from British Library Document Supply Centre- DSC:9091.9(TP--834) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Baseline sympathetic nerve activity.

<p>(<b>A</b>) Splanchnic sympathetic nerve activity (sSNA, n = 9) and (<b>B</b>) renal sympathetic nerve activity (rSNA, n = 9) at baseline level in the different groups. BDL, bile duct ligation. Error bars indicate SEM. *p < 0.05 compared to control group (Student’s t test).</p

Body and organ weights, organ weight-to-body weight ratio, and liver function parameters in control and bile duct ligation (BDL) experimental groups.

<p>Body and organ weights, organ weight-to-body weight ratio, and liver function parameters in control and bile duct ligation (BDL) experimental groups.</p

Baroreceptor reflex sensitivity for heart rate (HR).

<p>(<b>A</b>) Linear regression graph showing: depressor response—the reflexive increase in heart rate (ΔHR) to decrease the mean arterial pressure (ΔMAP) produced by acute administration of sodium nitroprusside (7, 17, and 20 μg/kg); and pressor response—HR decrease reflex response to increase MAP produced by acute administration of phenylephrine (3, 6, and 10 μg/kg) in the control and bile duction ligation (BDL) groups. n, number of rats. *P < 0.05 compared to control group (Sutdent’t test). (<b>B</b>) Representative recording of cardiovascular responses induced by acute infusion of phenylephrine (Phe) and sodium nitroprusside (SNP) in the control and BDL groups. Pulse pressure (PP), heart rate (HR), beats per minute (bpm) and mean arterial pressure (MAP).</p