Satellite Power System (SPS) concept definition study (exhibit C)

The major outputs of the study are the constructability studies which resulted in the definition of the concepts for satellite, rectenna, and satellite construction base construction. Transportation analyses resulted in definition of heavy-lift launch vehicle, electric orbit transfer vehicle, personnel orbit transfer vehicle, and intra-orbit transfer vehicle as well as overall operations related to transportation systems. The experiment/verification program definition resulted in the definition of elements for the Ground-Based Experimental Research and Key Technology plans. These studies also resulted in conceptual approaches for early space technology verification. The cost analysis defined the overall program and cost data for all program elements and phases

Diversity and the Future of Work: Examining the Future Workplace Through a Generational Lens

Talent management is a critical consideration for organizations in the increasingly uncertain and competitive business environment Human Resource Management is critical to the success of any organization operating in the current service and knowledge economies Ignoring generational differences can lead to an ineffective organizatio

Hope, Life Satisfaction, and Motivation

This study examined three types of motivation—autonomous, controlled and impersonal (Deci & Ryan, 1985)—in relation to life satisfaction and hope in a sample of persons living in transitional housing in central Indiana. It was hypothesized that life satisfaction and hope would be positively related to autonomous motivation and negatively related to impersonal motivation. Further, the relationship between life satisfaction, hope, and controlled motivation was explored. Data were analyzed using multiple regression analyses. While hypotheses were not supported, other important relationships were found in the data, such as interesting directional differences and correlations. How these findings may be particularly relevant to the homeless population are discussed

Analyzing Critical Factors: Motivating Project Managers

The concept of project management has evolved tremendously over the years. In addition to the technostructure changes that have taken place, the recent pandemic and sociocultural events and subsequent reflection that has occurred have impacted how people live and work. The purpose of this research study was to investigate the factors that create a culture of modern-day multigenerational project managers to be fully emotionally engaged when managing and leading organization projects. One hundred twenty practicing project managers working in a variety of industries representing different countries were interviewed. The findings identify the top six most frequently cited factors. The paper then explores ways to assist organizational leaders in design work environments that support modern-day multigenerational project managers to be fully emotionally engaged when managing and leading organization projects

APRIL:TACI axis is dispensable for the immune response to rabies vaccination.

There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination