566 research outputs found
Further genetic heterogeneity for autosomal dominant human sutural cataracts
A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent reason for isolated congenital cataracts, all 4 active CRYG genes have been sequenced. A single base-pair change in the CRYGA gene has been shown, leading to a premature stop codon. This was not observed in 170 control individuals. However, it did not segregate with the disease phenotype. This is the first truncating mutation in an active CRYG gene without a dominant phenotype. As the CRYGA mutation did not explain the cataract, several other candidate loci (CCV, GJA8, CRYBB2, BFSP2, MIP, GJA8, central pouch-like, CRYBA1) were investigated by micro-satellite markers and linkage analysis, but they were excluded based on the combination of haplotype analysis and two-point linkage analysis. The phenotype in this family is due to a mutation in another sutural cataract gene yet to be identified
0+ states and collective bands in 228Th studied by the (p,t) reaction
The excitation spectra in the deformed nucleus 228Th have been studied by
means of the (p,t)-reaction, using the Q3D spectrograph facility at the Munich
Tandem accelerator. The angular distributions of tritons were measured for
about 110 excitations seen in the triton spectra up to 2.5 MeV. Firm 0+
assignments are made for 17 excited states by comparison of experimental
angular distributions with the calculated ones using the CHUCK3 code.
Assignments up to spin 6+ are made for other states. Sequences of states are
selected which can be treated as rotational bands and as multiplets of
excitations. Moments of inertia have been derived from these sequences, whose
values may be considered as evidence of the two-phonon nature of most 0+
excitations. Experimental data are compared with interacting boson model and
quasiparticle-phonon model calculations and with experimental data for 229Pa.Comment: 21 pages, 14 figure
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Refinement of the crystal structure of diholmium trinickel hexaboride, Ho2Ni3B6
B6Ho2Ni3, orthorhombic, Cmmm (No. 65), a = 7.6865(9) Å, b = 8.6679(9) Å, c = 3.4742(4) Å, V = 231.5 Å3, Z = 2, Rgt(F) = 0.021, wRref(F2) = 0.048, T= 300 K
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Crystal structure of tetraholmium nickel tetradecaboride, Ho4NiB14
B14Ho4Ni, tetragonal, P4/mnc (No. 128), a = 7.2097(8) Å, c = 7.4587(9) Å, V = 387.7 Å3, Z = 2, Rgt(F) = 0.049, wRref(F2) = 0.087, T = 300 K
Electron-Phonon Coupling Origin of the resistivity in YNi_{2}B_{2}C Single Crystals
Resistivity measurements from 4.2 K up to 300 K were made on YNi_{2}B_{2}C
single crystals with Tc=15.5 K. The resulting rho(T) curve shows a perfect
Bloch-Grueneisen (BG) behavior, with a very small residual resistivity which
indicates the low impurity content and the high cristallographic quality of the
samples. The value lambda_{tr}=0.53 for the transport electron-phonon coupling
constant was obtained by using the high-temperature constant value of d(rho)/dT
and the plasma frequency reported in literature. The BG expression for the
phononic part of the resistivity rho_{ph}(T) was then used to fit the data in
the whole temperature range, by approximating alpha^{2}_{tr}F(Omega) with the
experimental phonon spectral density G(Omega) multiplied by a two-step
weighting function to be determined by the fit. The resulting fitting curve
perfectly agrees with the experimental points. We also solved the real-axis
Eliashberg equations in both s- and d-wave symmetries under the approximation
alpha^{2}F(Omega)= alpha^{2}_{tr}F(Omega). We found that the value of
lambda_{tr} here determined in single-band approximation is quite compatible
with Tc and the gap Delta experimentally observed. Finally, we calculated the
normalized tunneling conductance, whose comparison with break-junction tunnel
data gives indication of the possible s-wave symmetry for the order parameter
in YNi_{2}B_{2}C.Comment: 6 pages, 5 figures. Proceedings of SATT10 Conference, to be published
in Int. J. Mod. Phys.
New supersymmetric quartet of nuclei in the A=190 mass region
We present evidence for a new supersymmetric quartet in the A=190 region of
the nuclear mass table. New experimental information on transfer and neutron
capture reactions to the odd-odd nucleaus 194 Ir strongly suggests the
existence of a new supersymmetric quartet, consisting of the 192,193 Os and
193,194 Ir nuclei. We make explicit predictions for the odd-neutron nucleus 193
Os, and suggest that its spectroscopic properties be measured in dedicated
experiments.Comment: 5 pages, 4 figures, updated figures and revised text, Physical Review
C, Rapid Communication, in pres
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery. CHRNA7 is genetically linked to multiple disorders with cognitive deficits, including schizophrenia, bipolar disorder, ADHD, epilepsy, Alzheimer's disease, and Rett syndrome. The regulation of CHRNA7 is complex; more than a dozen mechanisms are known, one of which is a partial duplication of the parent gene. Exons 5–10 of CHRNA7 on chromosome 15 were duplicated and inserted 1.6 Mb upstream of CHRNA7, interrupting an earlier partial duplication of two other genes. The chimeric CHRFAM7A gene product, dupα7, assembles with α7 subunits, resulting in a dominant negative regulation of function. The duplication is human specific, occurring neither in primates nor in rodents. The duplicated α7 sequence in exons 5–10 of CHRFAM7A is almost identical to CHRNA7, and thus is not completely queried in high throughput genetic studies (GWAS). Further, pre-clinical animal models of the α7nAChR utilized in drug development research do not have CHRFAM7A (dupα7) and cannot fully model human drug responses. The wide expression of CHRNA7, its multiple functions and modes of regulation present challenges for study of this gene in disease
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