154 research outputs found
Data Portraits and Intermediary Topics: Encouraging Exploration of Politically Diverse Profiles
In micro-blogging platforms, people connect and interact with others.
However, due to cognitive biases, they tend to interact with like-minded people
and read agreeable information only. Many efforts to make people connect with
those who think differently have not worked well. In this paper, we
hypothesize, first, that previous approaches have not worked because they have
been direct -- they have tried to explicitly connect people with those having
opposing views on sensitive issues. Second, that neither recommendation or
presentation of information by themselves are enough to encourage behavioral
change. We propose a platform that mixes a recommender algorithm and a
visualization-based user interface to explore recommendations. It recommends
politically diverse profiles in terms of distance of latent topics, and
displays those recommendations in a visual representation of each user's
personal content. We performed an "in the wild" evaluation of this platform,
and found that people explored more recommendations when using a biased
algorithm instead of ours. In line with our hypothesis, we also found that the
mixture of our recommender algorithm and our user interface, allowed
politically interested users to exhibit an unbiased exploration of the
recommended profiles. Finally, our results contribute insights in two aspects:
first, which individual differences are important when designing platforms
aimed at behavioral change; and second, which algorithms and user interfaces
should be mixed to help users avoid cognitive mechanisms that lead to biased
behavior.Comment: 12 pages, 7 figures. To be presented at ACM Intelligent User
Interfaces 201
Discovering Polarized Communities in Signed Networks
Signed networks contain edge annotations to indicate whether each interaction
is friendly (positive edge) or antagonistic (negative edge). The model is
simple but powerful and it can capture novel and interesting structural
properties of real-world phenomena. The analysis of signed networks has many
applications from modeling discussions in social media, to mining user reviews,
and to recommending products in e-commerce sites. In this paper we consider the
problem of discovering polarized communities in signed networks. In particular,
we search for two communities (subsets of the network vertices) where within
communities there are mostly positive edges while across communities there are
mostly negative edges. We formulate this novel problem as a "discrete
eigenvector" problem, which we show to be NP-hard. We then develop two
intuitive spectral algorithms: one deterministic, and one randomized with
quality guarantee (where is the number of vertices in the
graph), tight up to constant factors. We validate our algorithms against
non-trivial baselines on real-world signed networks. Our experiments confirm
that our algorithms produce higher quality solutions, are much faster and can
scale to much larger networks than the baselines, and are able to detect
ground-truth polarized communities
Real Field Deployment of a Smart Fiber Optic Surveillance System for Pipeline Integrity Threat Detection: Architectural Issues and Blind Field Test Results
This paper presents an on-line augmented surveillance
system that aims to real time monitoring of activities
along a pipeline. The system is deployed in a fully realistic
scenario and exposed to real activities carried out in unknown
places at unknown times within a given test time interval (socalled
blind field tests). We describe the system architecture that
includes specific modules to deal with the fact that continuous
on-line monitoring needs to be carried out, while addressing
the need of limiting the false alarms at reasonable rates. To
the best or our knowledge, this is the first published work in
which a pipeline integrity threat detection system is deployed
in a realistic scenario (using a fiber optic along an active gas
pipeline) and is thoroughly and objectively evaluated in realistic
blind conditions. The system integrates two operation modes:
The machine+activity identification mode identifies the machine
that is carrying out a certain activity along the pipeline, and the
threat detection mode directly identifies if the activity along the
pipeline is a threat or not. The blind field tests are carried out
in two different pipeline sections: The first section corresponds
to the case where the sensor is close to the sensed area, while
the second one places the sensed area about 35 km far from
the sensor. Results of the machine+activity identification mode
showed an average machine+activity classification rate of 46:6%.
For the threat detection mode, 8 out of 10 threats were correctly
detected, with only 1 false alarm appearing in a 55:5-hour sensed
period.European CommissionMinisterio de EconomÃa y CompetitividadComunidad de Madri
SARS-CoV-2 Catalonia contact tracing program : evaluation of key performance indicators
Background: Guidance on SARS-CoV-2 contact tracing indicators have been recently revised by international public health agencies. The aim of the study is to describe and analyse contact tracing indicators based on Catalonia's (Spain) real data and proposing to update them according to recommendations. Methods: Retrospective cohort analysis including Catalonia's contact tracing dataset from 20 May until 31 December 2020. Descriptive statistics are performed including sociodemographic stratification by age, and differences are assessed over the study period. Results: We analysed 923,072 contacts from 301,522 SARS-CoV-2 cases with identified contacts (67.1% contact tracing coverage). The average number of contacts per case was 4.6 (median 3, range 1-243). A total of 403,377 contacts accepted follow-up through three phone calls over a 14-day quarantine period (84.5% of contacts requiring follow-up). The percentage of new cases declared as contacts 14 days prior to diagnosis evolved from 33.9% in May to 57.9% in November. All indicators significantly improved towards the target over time (p < 0.05 for all four indicators). Conclusions: Catalonia's SARS-CoV-2 contact tracing indicators improved over time despite challenging context. The critical revision of the indicator's framework aims to provide essential information in control policies, new indicators proposed will improve system delay's follow-up. The study provides information on COVID-19 indicators framework experience from country's real data, allowing to improve monitoring tools in 2021-2022. With the SARS-CoV-2 pandemic being so harmful to health systems and globally, is important to analyse and share contact tracing data with the scientific community
EMMPRIN Promotes Melanoma Cells Malignant Properties through a HIF-2alpha Mediated Up-Regulation of VEGF-Receptor-2
EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis. Here we demonstrate that EMMPRIN up-regulated VEGF receptor-2 (VEGFR-2) in two different primary melanoma cell lines and consequently increased migration and proliferation of these cells while inhibiting their apoptosis. SiRNA inhibition of VEGFR-2 expression abrogated these EMMPRIN effects. EMMPRIN regulation of VEGFR-2 was mediated through the over-expression of HIF-2α and its translocation to the nucleus where it forms heterodimers with HIF-1β. These results were supported by an in vivo correlation between the expression of EMMPRIN with that of VEGFR-2 in human melanoma tissues as well as with the extent of HIF-2α localization in the nucleus. They demonstrate a novel mechanism by which EMMPRIN promotes tumor progression through HIF-2α/VEGFR-2 mediated mechanism, with an autocrine role in melanoma cell malignancy. The inhibition of EMMPRIN in cancer may thus simultaneously target both the VEGFR-2/VEGF system and the matrix degrading proteases to block tumor cell growth and invasion
The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose-containing glycoconjugate in <i>Plasmodium</i> asexual blood stages
Glycosylation is an important posttranslational protein
modification in all eukaryotes. Besides
glycosylphosphatidylinositol (GPI) anchors and N-glycosylation,
O-fucosylation has been recently reported in key sporozoite
proteins of the malaria parasite. Previous analyses showed the
presence of GDP-fucose (GDP-Fuc), the precursor for all
fucosylation reactions, in the blood stages of Plasmodium
falciparum. The GDP-Fuc de novo pathway, which requires the
action of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose
synthase (FS), is conserved in the parasite genome, but the
importance of fucose metabolism for the parasite is unknown. To
functionally characterize the pathway we generated a PfGMD
mutant and analyzed its phenotype. Although the labelling by the
fucose-binding Ulex europaeus agglutinin I (UEA-I) was
completely abrogated, GDP-Fuc was still detected in the mutant.
This unexpected result suggests the presence of an alternative
mechanism for maintaining GDP-Fuc in the parasite. Furthermore,
PfGMD null mutant exhibited normal growth and invasion rates,
revealing that the GDP-Fuc de novo metabolic pathway is not
essential for the development in culture of the malaria parasite
during the asexual blood stages. Nonetheless, the function of
this metabolic route and the GDP-Fuc pool that is generated
during this stage may be important for gametocytogenesis and
sporogonic development in the mosquito
Therapy for metastatic melanoma: the past, present, and future
Metastatic melanoma is the most aggressive form of skin cancer with a median overall survival of less than one year. Advancements in our understanding of how melanoma evades the immune system as well as the recognition that melanoma is a molecularly heterogeneous disease have led to major improvements in the treatment of patients with metastatic melanoma. In 2011, the US Food and Drug Administration (FDA) approved two novel therapies for advanced melanoma: a BRAF inhibitor, vemurafenib, and an immune stimulatory agent, ipilimumab. The success of these agents has injected excitement and hope into patients and clinicians and, while these therapies have their limitations, they will likely provide excellent building blocks for the next generation of therapies. In this review we will discuss the advantages and limitations of the two new approved agents, current clinical trials designed to overcome these limitations, and future clinical trials that we feel hold the most promise
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