22,192 research outputs found

    Influence of perineural invasion in predicting overall survival and disease-free survival in patients With locally advanced gastric cancer

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    Background The aim of the present study was to evaluate the prognostic significance of perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 gastrectomy and adjuvant chemotherapy. Methods The records of a series of 103 patients undergoing D2 gastrectomy with curative intent combined with adjuvant chemotherapy from January 2004 to December 2014 were retrospectively reviewed. Results PNI was positive in 47 (45.6%) specimens. The 1-, 3-, and 5-year overall survival rates were 81%, 55%, and 42%, respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 76%, 57%, and 49%, respectively. A multivariate analysis showed that age number of positive lymph nodes, T stage, and PNI were independently associated with overall survival. Regarding DFS, the multivariate analysis showed that only PNI was independently associated with DFS. Conclusions PNI and T stage and positive lymph nodes are independent markers of poor prognosis in patients with gastric cancer. PNI should be incorporated in the postoperative staging system for planning follow-up after surgery and in our opinion to propose more aggressive postoperative therapies in PNI-positive patients

    Nuclear effects in dAu collisions from recent RHIC data

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    Neutral pion (pi(0)) production is calculated in a leading order (LO) perturbative QCD-based model in pp and dAu collisions at root s = 200 AGeV at midrapidity. The model includes transverse component of the initial parton distribution. We compare our results for pp collision to experimental data at RHIC energy. We repeat our calculation for the dAu collision and investigate the interplay between shadowing and multiple scattering. In central dAu collisions the influence of possible jet energy loss in cold nuclear matter in discussed and numerical results are presented

    The nuclear modification factor at large rapidities

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    RHIC data on high-pT hadron production display strong suppression in a wide rapidity region, indicating strong induced energy loss for both transversally and longitudinally traveling partons. We investigate the interplay of energy loss and rapidity dependence in a perturbative QCD improved parton model, and estimate the opacity of the produced hot matter in AuAu collisions at energies sqrt(s) = 200 A GeV and 63 AGeV at different rapidity values. Direction-dependent suppression offers the possibility to study the geometry of the hot matter. © 2006 Elsevier B.V. All rights reserved

    Delay-induced rebounds in CO_{2} emissions and critical time-scales to meet global warming targets

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    While climate science debates are focused on the attainment of peak anthropogenic CO2 emissions and policy tools to reduce peak temperatures, the human‐energy‐climate system can hold “rebound” surprises beyond this peak. Following the second industrial revolution, global per capita CO_{2} emissions (c_{c}) experienced a punctuated growth of about 100% every 60 years, mainly attributable to technological development and its global spread. A model of the human‐energy‐climate system capable of reproducing past punctuated dynamics shows that rebounds in global CO_{2} emissions emerge due to delays intrinsic to the diffusion of innovations. Such intrinsic delays in the adoption and spread of low‐carbon emitting technologies, together with projected population growth, upset the warming target set by the Paris Agreement. To avoid rebounds and their negative climate effects, model calculations show that the diffusion of climate‐friendly technologies must occur with lags one‐order of magnitude shorter (i.e., ∼6 years) than the characteristic timescale of past punctuated growth in c_{c}. Radically new strategies to globally implement the technological advances at unprecedented rates are needed if the current emission goals are to be achieved
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