1,031 research outputs found
Computed tomography and magnetic resonance diagnosis of variations in the anatomical location of the major salivary glands in 1680 dogs and 187 cats
During assessment of routine clinical magnetic resonance imaging (MRI) of the heads of dogs, variations in the location of mandibular and zygomatic salivary glands (SGs) were observed incidentally. The aims of this retrospective study were to describe anatomical variations of the major SGs found on MRI and computed tomography (CT) studies of the head in dogs and cats and to investigate possible clinical relevancy.
No anatomical variation of the SGs was seen in cats, but in dogs, although variation of the parotid SG was not identified, that of the mandibular SG was found in 33/1680 animals (2%), either unilaterally (6/33 right-sided, 13/33 left-sided) or bilaterally (14/33). The Border terrier breed (19/33, 58%) was over-represented. Each atypically located mandibular SG was positioned medial to the digastric muscle and rostral to the retropharyngeal lymph node. The sublingual glands were difficult to delineate from the mandibular glands. Anatomical variation of one zygomatic gland (3/4 left-sided) was identified in four small-breed dogs (0.2%). Each atypically located zygomatic gland was tilted at the ventrorostral aspect of the masseter muscle underneath the skin surface. MRI and CT characteristics were not different between typically and atypically located SGs. None of the dogs had clinical signs related with SG disease. It was concluded that, with suspected breed predispositions, incidental unilateral or bilateral anatomical variations of mandibular and zygomatic SGs can be encountered in dogs and an awareness of these possible variations may be important in pre-surgical planning
A hypothalamic channel-system in the inferior lobes of a trigger-fish (Rhinecanthus aculeatus, Balistidae)
In the course of a general investigation of the optic system in some trigger-fishes, a hypothalamic, ventricular channel-system with pores, leading to the outside of the brain, has been discovered in the inferior lobes ofRhinecanthus aculeatus (Balistidae). A description of the morphological relations of the channel-system to the blood-vessel-supply and the cranium suggests that the organ-systems involved form a functional unit. The possibility of a hormone-producing system is discussed in the light of physiological and ecological aspects
Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of metabolic abnormalities ranging from simple hepatic steatosis (accumulation of neutral lipid) to development of steatotic lesions, steatohepatitis, and cirrhosis. NAFLD is extremely prevalent in obese individuals and with the epidemic of obesity; nonalcoholic steatohepatitis (NASH) has become the most common cause of liver disease in the developed world. NASH is rapidly emerging as a prominent cause of liver failure and transplantation. Moreover, hepatic steatosis is tightly linked to risk of developing insulin resistance, diabetes, and cardiovascular disease. Abnormalities in hepatic lipid metabolism are part and parcel of the development of NAFLD and human genetic studies and work conducted in experimentally tractable systems have identified a number of enzymes involved in fat synthesis and degradation that are linked to NAFLD susceptibility as well as progression to NASH. The goal of this review is to summarize the current state of our knowledge on these pathways and focus on how they contribute to etiology of NAFLD and related metabolic diseases
The PPARα-PGC-1α Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium
The mammalian myocardium is an omnivorous organ that relies on multiple substrates in order to fulfill its tremendous energy demands. Cardiac energy metabolism preference is regulated at several critical points, including at the level of gene transcription. Emerging evidence indicates that the nuclear receptor PPARα and its cardiac-enriched coactivator protein, PGC-1α, play important roles in the transcriptional control of myocardial energy metabolism. The PPARα-PGC-1α complex controls the expression of genes encoding enzymes involved in cardiac fatty acid and glucose metabolism as well as mitochondrial biogenesis. Also, evidence has emerged that the activity of the PPARα-PGC-1α complex is perturbed in several pathophysiologic conditions and that altered activity of this pathway may play a role in cardiomyopathic remodeling. In this review, we detail the current understanding of the effects of the PPARα-PGC-1α axis in regulating mitochondrial energy metabolism and cardiac function in response to physiologic and pathophysiologic stimuli
Exploiting neutron-rich radioactive ion beams to constrain the symmetry energy
The Modular Neutron Array (MoNA) and 4 Tm Sweeper magnet were used to measure
the free neutrons and heavy charged particles from the radioactive ion beam
induced 32Mg + 9Be reaction. The fragmentation reaction was simulated with the
Constrained Molecular Dynamics model(CoMD), which demonstrated that the
of the heavy fragments and free neutron multiplicities were observables
sensitive to the density dependence of the symmetry energy at sub-saturation
densities. Through comparison of these simulations with the experimental data
constraints on the density dependence of the symmetry energy were extracted.
The advantage of radioactive ion beams as a probe of the symmetry energy is
demonstrated through examination of CoMD calculations for stable and
radioactive beam induced reactions
Three-body correlations in the ground-state decay of 26O
Background: Theoretical calculations have shown that the energy and angular
correlations in the three-body decay of the two-neutron unbound O26 can provide
information on the ground-state wave function, which has been predicted to have
a dineutron configuration and 2n halo structure.
Purpose: To use the experimentally measured three-body correlations to gain
insight into the properties of O26, including the decay mechanism and
ground-state resonance energy.
Method: O26 was produced in a one-proton knockout reaction from F27 and the
O24+n+n decay products were measured using the MoNA-Sweeper setup. The
three-body correlations from the O26 ground-state resonance decay were
extracted. The experimental results were compared to Monte Carlo simulations in
which the resonance energy and decay mechanism were varied.
Results: The measured three-body correlations were well reproduced by the
Monte Carlo simulations but were not sensitive to the decay mechanism due to
the experimental resolutions. However, the three-body correlations were found
to be sensitive to the resonance energy of O26. A 1{\sigma} upper limit of 53
keV was extracted for the ground-state resonance energy of O26.
Conclusions: Future attempts to measure the three-body correlations from the
ground-state decay of O26 will be very challenging due to the need for a
precise measurement of the O24 momentum at the reaction point in the target
Search for unbound 15Be states in the 3n+12Be channel
15Be is expected to have low-lying 3/2+ and 5/2+ states. A first search did
not observe the 3/2+ [A. Spyrou et al., Phys. Rev. C 84, 044309 (2011)],
however, a resonance in 15Be was populated in a second attempt and determined
to be unbound with respect to 14Be by 1.8(1) MeV with a tentative spin-parity
assignment of 5/2+ [J. Snyder et al., Phys. Rev. C 88, 031303(R) (2013)].
Search for the predicted 15Be 3/2+ state in the three-neutron decay channel. A
two-proton removal reaction from a 55 MeV/u 17C beam was used to populate
neutron-unbound states in 15Be. The two-, three-, and four-body decay energies
of the 12Be + neutron(s) detected in coincidence were reconstructed using
invariant mass spectroscopy. Monte Carlo simulations were performed to extract
the resonance and decay properties from the observed spectra. The low-energy
regions of the decay energy spectra can be described with the first excited
unbound state of 14Be (E_x=1.54 MeV, E_r=0.28 MeV). Including a state in 15Be
that decays through the first excited 14Be state slightly improves the fit at
higher energies though the cross section is small. A 15Be component is not
needed to describe the data. If the 3/2+ state in 15Be is populated, the decay
by three-neutron emission through 14Be is weak, less than or equal to 11% up to
4 MeV. In the best fit, 15Be is unbound with respect to 12Be by 1.4 MeV
(unbound with respect to $14Be by 2.66 MeV) with a strength of 7%.Comment: 6 pages, 5 figures, accepted in Physical Review
Spectroscopy of neutron-unbound F
The ground state of F has been observed as an unbound resonance
keV above the ground state of F. Comparison of this
result with USDA/USDB shell model predictions leads to the conclusion that the
F ground state is primarily dominated by -shell configurations. Here
we present a detailed report on the experiment in which the ground state
resonance of F was first observed. Additionally, we report the first
observation of a neutron-unbound excited state in F at an excitation
energy of keV.Comment: 10 pages, 11 figures, Accepted for publication in Phys. Rev.
Double di ffential fragmentation cross sections measurements of 95 MeV/u 12C on thin targets for hadrontherapy
During therapeutic treatment with heavy ions like carbon, the beam undergoes
nuclear fragmentation and secondary light charged particles, in particular
protons and alpha particles, are produced. To estimate the dose deposited into
the tumors and the surrounding healthy tissues, an accurate prediction on the
fluences of these secondary fragments is necessary. Nowadays, a very limited
set of double di ffential carbon fragmentation cross sections are being
measured in the energy range used in hadrontherapy (40 to 400 MeV/u).
Therefore, new measurements are performed to determine the double di ffential
cross section of carbon on di erent thin targets. This work describes the
experimental results of an experiment performed on May 2011 at GANIL. The
double di ffential cross sections and the angular distributions of secondary
fragments produced in the 12C fragmentation at 95 MeV/u on thin targets (C,
CH2, Al, Al2O3, Ti and PMMA) have been measured. The experimental setup will be
precisely described, the systematic error study will be explained and all the
experimental data will be presented.Comment: Submitted to PR
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