On Characterizing the Data Access Complexity of Programs

Technology trends will cause data movement to account for the majority of energy expenditure and execution time on emerging computers. Therefore, computational complexity will no longer be a sufficient metric for comparing algorithms, and a fundamental characterization of data access complexity will be increasingly important. The problem of developing lower bounds for data access complexity has been modeled using the formalism of Hong & Kung's red/blue pebble game for computational directed acyclic graphs (CDAGs). However, previously developed approaches to lower bounds analysis for the red/blue pebble game are very limited in effectiveness when applied to CDAGs of real programs, with computations comprised of multiple sub-computations with differing DAG structure. We address this problem by developing an approach for effectively composing lower bounds based on graph decomposition. We also develop a static analysis algorithm to derive the asymptotic data-access lower bounds of programs, as a function of the problem size and cache size

Synthesis and Characterization of Novel Schiff base Cu(II) Complexes: Antimicrobial and Molecular docking Studies

N2O2 type complexes of C+2uion have been synthesized by the reaction of Salicylaldehyde/ 3,4-diaminobenzophenone/ acetyl acetoneand glutaric anhydride. The ligands and respective metal complexes was established through spectroscopic data (FT-IR, UV-Vis,1H NMR and 13C NMR). They are non-electrolytic in nature as their molar conductivities (ΛM) in DMSO of 10-3 M solution from the EPR study the complexes proposed to be octahedral geometry. All the metal complexes have been screened for their antibacterial activity andthe predicted binding affinity using molecular docking studies

Development of a New RP-UPLC Method for the Determination of Rabeprazole Sodium in Pharmaceutical Formulation and Application in Dissolution Studies

Purpose: To develop a reverse phase ultra-performance liquid chromatographic (RP-UPLC) method for the estimation of rabeprazole sodium in tablet formulations.Methods: Chromatographic separation was achieved on a Waters Acquity BEH C18 (50 x 2.1 mm, particle size 1.7 μm) column using an isocratic method with mobile phase composed of acetonitrile and phosphate buffer (pH 7.4) in the ratio of 35:65 (v/v). The flow rate was 0.4 ml/min, temperature of the column was maintained at ambient, injection volume was 5 μL and detection was made at 280 nm. The run time was as short as 2 min. Comparison of system performance with conventional HPLC was made with respect to analysis time, efficiency and sensitivity.Results: The developed method was linear for rabeprazole sodium from 0.03 - 30 μg/ml and the linear regression obtained was > 0.999. Precision, evaluated by intra- and inter-day assay,s had relative standard deviation (R.S.D) values within 1.5 %. Recovery data were in the range 98.0 - 101.5 % with R.S.D. values < 1.5 %.Conclusion: The method is precise, accurate, linear, robust and fast. The short retention time of 1.49 min allows the analysis of a large number of samples in a short period of time and, therefore, should be cost-effective for routine analysis in the pharmaceutical industry.Keywords: Ultra performance liquid chromatography, Assay, Rabeprazole sodium, Validatio

Investigation on Performance of Pulsating Heat Pipe

The main aim is analysis the performance of pulsating heat pipe with open loop system. This design has effective to enhance the performance of heat pipe. The heat pipe having various limitations like capillary limit, boiling limit, entrainment limit, sonic limit etc. In this work, we analyze the overall heat transfer coefficient, heat transfer efficiency of the heat piper for different heat input and angle of variations. The work has been made with DI Water as working fluids. The performance of pulsating heat pipe tends to be better with heat pipe fabricated with 10mm size with Heat input of 50 W at angle inclination 45⁰

Retrospective analysis of conservatively treated thoracolumbar burst fracture

Background: Thoracolumbar burst fractures accounts for 10 to 40 percent of the spinal column fractures caries a significant morbidity and mortality. Vertebral fractures are usually followed by chronic pain, deformity, loss of height and crowding of internal organs. A combination of the above problems can adversely affect the self-esteem and ability to carry on the daily activities.The objective of the study was to find proportion of the conservatively treated thoracolumbar burst fracture and the factors associated with the final outcome of the treatment with the clinical, radiological evidences.Methods: In this study 36 patients with burst fracture of thoracolumbar spine without neurological deficit, treated conservatively from January 2015–August 2016 were included. The overall follow up period was 18 months. Various radiological parameters were taken in to consideration like Cobb angle, canal stenosis, sagittal alignment, and fragment displacement. Treatment outcome was evaluated by short form survey questionnaire (SF-36), Denis score for pain and work and the visual analogue scale (VAS).Results: The overall functional outcome in this study group 30.55% returned to the previous employment. 25% back to their previous job with restrictions.27.7% unable to return to the previous job but works fulltime in a new job. 16.7% unable to return to full time work. No one is completely disabled. The Cobb angle remains same or decreased in 53% and in 47% with minimum -8 maximum 5. The severe pain score was in 5.6% of cases. Conclusions: Proper selection of patients and their prior activities, social and educational background and future plans in addition to a thorough physical, neurological and spinal examination are mandatory to achieve satisfactory result

Evaluation of the poly herbal drug: Keelvayu Nivarana Churnam

Siddha Medicine is regaining its lost glory throughout the World. For the universal acceptations of Siddha medicine we should standardize by scientific validation at various levels. Herbals have been an important source of medicine with qualities for thousands of years.  Phytochemicals are the active principles of the herbal drug. Keelvayu nivarana churnam is one of the poly herbal drugs used for Arthritis. In this study we carried out powder microscopy for identification of the ingredient medicinal plants.  We studied Physicochemical parameters like appearance, pH, total ash, loss on drying; water soluble extractive, alcohol soluble extractive, bulk density and tap density are evaluated.  In Phyotochemical screening the presence or absence of alkaloids, flavanoides, tannins, proteins, sterols, carbohydrates, glycosides, terpenoides, saponins and starch. We did Gas chromatography and Mass spectroscopy (GC-MS/MS) for the identification of bioactive compounds of Keelvayu nivarana churnam. These findings support the therapeutic value of Keelvayu nivarana churnam in Arthritis. Keywords: Arthritis; Keelvayu nivarana churnam; Powder Microscopy; Physicochemistry and Phytochemistry; Gas chromatography–mass spectrometry (GC-MS/MS)

Mechanical and Corrosion Properties of Friction Stir Welded and Tungsten Inert Gas Welded Phosphor Bronze

This study investigated the mechanical and corrosion properties of Friction Stir Welded (FSW) and Tungsten Inert Gas (TIG) welded phosphor bronze (CuSn4) joints. Corrosion tests were conducted on the welded joints, and the percentage of weight loss due to corrosion was measured at different time intervals. Results revealed that the percentage of weight loss due to corrosion of the TIG joint increased with time, whereas the percentage of weight loss due to corrosion of the FSW welded joint remained constant. This could be attributed to recrystallisation that happened in the solid-state welding, which reduced corrosion in the FSW welded joint. In addition, tensile tests were conducted to evaluate the strength of the joints. FSW with a spindle speed of 1300 rpm, weld speed of 0.06mm/sec, plunge depth of 0.25mm, pin profile of pentagon, and flat shoulder profile was found to produce good results. TIG welding with a welding speed of 1.75mm/sec, a gas flow rate of 7.5 cm3/min and an amperage of 120A also produced good results. The tensile strength of FSW was found to be approximately 1.6 times higher than that of TIG welding

A comprehensive review on Nipah virus infection control measures

Nipah virus (NiV) has emerged as a deadly zoonotic pathogen, causing sporadic outbreaks with high mortality rates. The patient typically exhibits thrombocytopenia, leukopenia, and transaminitis along with fever, encephalitis, and/or respiratory involvement. This comprehensive review delves into the multifaceted realm of Nipah virus infection control measures. We explore the latest research, strategies, and practices aimed at preventing, containing, and mitigating the impact of NiV outbreaks. From surveillance and diagnosis to treatment and public health interventions, this review offers a holistic perspective on the ongoing efforts to combat this deadly virus

Real-Time Sequential Conic Optimization for Multi-Phase Rocket Landing Guidance

We introduce a multi-phase rocket landing guidance framework that can handle nonlinear dynamics and does not mandate any additional mixed-integer or nonconvex constraints to handle discrete temporal events/switching. To achieve this, we first introduce sequential conic optimization (SeCO), a new paradigm for solving nonconvex optimal control problems that is entirely devoid of matrix factorizations and inversions. This framework combines sequential convex programming (SCP) and first-order conic optimization and can solve unified multi-phase trajectory optimization problems in real-time. The novel features of this framework are: (1) time-interval dilation, which enables multi-phase trajectory optimization with free-transition-time; (2) single-crossing compound state-triggered constraints, which are entirely convex if the trigger and constraint conditions are convex; (3) virtual state, which is a new approach to handling artificial infeasibility in SCP methods that preserves the shapes of the constraint sets; and, (4) the use of the proportional-integral projected gradient method (PIPG), a high-performance first-order conic optimization solver, in tandem with the penalized trust region (PTR) SCP algorithm. We demonstrate the efficacy and real-time capability of SeCO by solving a relevant multi-phase rocket landing guidance problem with nonlinear dynamics and convex constraints only, and observe that our solver is 2.7 times faster than a state-of-the-art convex optimization solver