Towards High-Precision Parton Distributions from Lattice QCD via Distillation

We apply the Distillation spatial smearing program to the extraction of the unpolarized isovector valence PDF of the nucleon. The improved volume sampling and control of excited-states afforded by distillation leads to a dramatically improved determination of the requisite Ioffe-time Pseudo-distribution (pITD). The impact of higher-twist effects is subsequently explored by extending the Wilson line length present in our non-local operators to one half the spatial extent of the lattice ensemble considered. The valence PDF is extracted by analyzing both the matched Ioffe-time Distribution (ITD), as well as a direct matching of the pITD to the PDF. Through development of a novel prescription to obtain the PDF from the pITD, we establish a concerning deviation of the pITD from the expected DGLAP evolution of the pseudo-PDF. The presence of DGLAP evolution is observed once more following introduction of a discretization term into the PDF extractions. Observance and correction of this discrepancy further highlights the utility of distillation in such structure studies

Toward the Determination of the Gluon Helicity Distribution in the Nucleon from Lattice Quantum Chromodynamics

We present the first exploratory lattice quantum chromodynamics (QCD) calculation of the polarized gluon Ioffe-time pseudodistribution in the nucleon. The Ioffe-time pseudodistribution provides a frame-independent and gauge-invariant framework to determine the gluon helicity in the nucleon from first principles. We employ a high-statistics computation using a 323 × 64 lattice ensemble characterized by a 358 MeV pion mass and a 0.094 fm lattice spacing. We establish the pseudodistribution approach as a feasible method to address the proton spin puzzle with successive improvements in statistical and systematic uncertainties anticipated in the future. Within the statistical precision of our data, we find a good comparison between the lattice determined polarized gluon Ioffe-time distribution and the corresponding expectations from the state-of-the-art global analyses. We find a hint for a nonzero gluon spin contribution to the proton spin from the model-independent extraction of the gluon helicity pseudodistribution over a range of Ioffe-time, ν ≲ 9

Tethered balloon-borne profile measurements of atmospheric properties in the cloudy atmospheric boundary layer over the Arctic sea ice during MOSAiC: Overview and first results

The tethered balloon-borne measurement system BELUGA (Balloon-bornE moduLar Utility for profilinG the lower Atmosphere) was deployed over the Arctic sea ice for 4 weeks in summer 2020 as part of the Multidisciplinary drifting Observatory for the Study of Arctic Climate expedition. Using BELUGA, vertical profiles of dynamic, thermodynamic, aerosol particle, cloud, radiation, and turbulence properties were measured from the ground up to a height of 1,500 m. BELUGA was operated during an anomalously warm period with frequent liquid water clouds and variable sea ice conditions. Three case studies of liquid water phase, single-layer clouds observed on 3 days (July 13, 23, and 24, 2020) are discussed to show the potential of the collected data set to comprehensively investigate cloud properties determining cloud evolution in the inner Arctic over sea ice. Simulated back-trajectories show that the observed clouds have evolved within 3 different air masses (“aged Arctic,” “advected over sea ice,” and “advected over open ocean”), which left distinct fingerprints in the cloud properties. Strong cloud top radiative cooling rates agree with simulated results of previous studies. The weak warming at cloud base is mostly driven by the vertical temperature profile between the surface and cloud base. In-cloud turbulence induced by the cloud top cooling was similar in strength compared to former studies. From the extent of the mixing layer, it is speculated that the overall cloud cooling is stronger and thus faster in the warm oceanic air mass. Larger aerosol particle number concentrations and larger sizes were observed in the air mass advected over the sea ice and in the air mass advected over the open ocean

Unpolarized Gluon Distribution in the Nucleon From Lattice Quantum Chromodynamics

In this study, we present a determination of the unpolarized gluon Ioffe-time distribution in the nucleon from a first principles lattice quantum chromodynamics calculation. We carry out the lattice calculation on a 323 × 64 ensemble with a pion mass of 358 MeV and lattice spacing of 0.094 fm. We construct the nucleon interpolating fields using the distillation technique, flow the gauge fields using the gradient flow, and solve the summed generalized eigenvalue problem to determine the gluonic matrix elements. Combining these techniques allows us to provide a statistically well-controlled Ioffe-time distribution and unpolarized gluon parton distribution function. We obtain the flow time independent reduced Ioffe-time pseudodistribution and calculate the light-cone Ioffe-time distribution and unpolarized gluon distribution function in the MS scheme at μ = 2  GeV, neglecting the mixing of the gluon operator with the quark singlet sector. Finally, we compare our results to phenomenological determinations

Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis

We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin’s lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003–12/2007 were included into this analysis. At cerebral relapse, 15/23 patients were treated with a regimen consisting of high-dose methotrexate (Bonn protocol). After a median follow-up of 6.5 months (range 1–68), 15/23 (65%) patients with SCNSL had relapsed or progressed. HD (high-dose)- methotrexate (MTX) chemotherapy according to the Bonn protocol is effective concerning response rates; however, overall survival of patients with SCNSL seems to be impaired in comparison to relapses in primary CNSL (PCNSL)

Inositol Hexakisphosphate-Induced Autoprocessing of Large Bacterial Protein Toxins

Large bacterial protein toxins autotranslocate functional effector domains to the eukaryotic cell cytosol, resulting in alterations to cellular functions that ultimately benefit the infecting pathogen. Among these toxins, the clostridial glucosylating toxins (CGTs) produced by Gram-positive bacteria and the multifunctional-autoprocessing RTX (MARTX) toxins of Gram-negative bacteria have distinct mechanisms for effector translocation, but a shared mechanism of post-translocation autoprocessing that releases these functional domains from the large holotoxins. These toxins carry an embedded cysteine protease domain (CPD) that is activated for autoprocessing by binding inositol hexakisphosphate (InsP6), a molecule found exclusively in eukaryotic cells. Thus, InsP6-induced autoprocessing represents a unique mechanism for toxin effector delivery specifically within the target cell. This review summarizes recent studies of the structural and molecular events for activation of autoprocessing for both CGT and MARTX toxins, demonstrating both similar and potentially distinct aspects of autoprocessing among the toxins that utilize this method of activation and effector delivery