206 research outputs found
Relaxation of Chemical Reactions to Stationary States in the Chemical Affinities Space
Using the mass balance equations for chemical reactions, we show how the
system relaxes towards a steady state in and out of the Onsager region. In the
chemical affinities space, after fast transients, the relaxation process is a
straight line when operating in the Onsager region, while out of this regime,
the evolution of the system is such that the projections of the evolution
equations for the forces and the shortest path on the flows coincide. For
spatially-extended systems, similar results are valid for the evolution of the
thermodynamic mode (i.e., the mode with wave-number k = 0). These results allow
us to obtain the expression for the affine connection of the space covered by
the thermodynamic forces, close to the steady states. Through the affine
connection, the nonlinear closure equations are derived.Comment: 23 pages
Assessment of Lactobacillus crispatus´ role in vaginal infections: friend or foe?
Lactobacillus spp. are the most prevalent microorganisms in the vaginal milleu. Several probiotic mechanisms have been associated with Lactobacillus, but the most relevant one is lactate production – resulting in a low pH value, typical of the healthy vagina. However, its pathogenic state is still unknown. We aim to elucidate the role of a commensal vaginal microorganism, Lactobacillus crispatus, in vaginal infections. Twenty-four vaginal washes have been collected from women attending a gynaecology consultation of a private clinic. The samples were categorized according with clinical diagnosis at the time of sampling. The distribution of bacterial species, and their prevalence was assessed by Next-Generation Sequencing of the 16S rRNA V4 region. In addition, L- and D-lactate concentration, and LDH enzymatic activity was quantified in all washes by a commercial kit. Detection of Candida spp. was performed by PCR. L. crispatus was dominant (>70%) in 11 out of 24 samples – diagnosed for vaginal atrophy (VA, 3), cytolytic vaginosis (CV, 2) and lactobacillosis (LB, 2). Lactate was increased in CV, LB and VA cases only. The remaining samples, diagnosed for vulvovaginal candidosis in its majority, had lower prevalence of L. crispatus; and lower to moderate lactate metabolite. There was not a direct relationship between LDH enzymatic activity and clinical diagnosis. L. crispatus dominance, associated with increased lactate production, was observed in CV, LB and VA cases. These results indicate that this microorganism might have a role in dysbiosis of the vagina associated with these specific pathologies.info:eu-repo/semantics/publishedVersio
Role of Lactobacillus crispatus in vaginal infections: insights from metagenomics and metabolomics studies
Objective: Lactobacillus spp. constitute the most prevalent bacterial microorganism in the vaginal milleu. Several probiotic mechanisms have been associated with Lactobacillus, but the most relevant one is lactate production – resulting in a low pH value, typical of the healthy vagina. We aim to elucidate the role of a native vaginal microorganism, Lactobacillus crispatus, in vaginal infections.
Methods: Twenty-four vaginal washes have been collected from women (mean 38±14 years of age) attending a gynecology consultation of a private clinic. The samples were categorized according with clinical diagnosis at the time of sampling. The distribution of bacterial species, and their prevalence was assessed by next-generation sequencing of the 16S V4 region. In addition, lactate was quantified in all washes by a commercial kit.
Results: L. crispatus was dominant (>70%) in 11 out of 24 samples – diagnosed for vaginal atrophy (VA, 3), cytolytic vaginosis (CV, 2), lactobacillosis (LB, 2) and vulvovaginal candidosis (VVC, 1). For three samples, diagnostic was inconclusive. Lactate was increased in CV, LB and VA cases only. One sample, diagnosed with VVC had 23% dominance of L. crispatus; and lower lactate metabolite. L. crispatus was not detected in the remaining 12 cases (6 VVC, 4 VA, 1 healthy and 1 inconclusive). Of these, only 5 samples had moderate lactate metabolite.
Conclusions: L. crispatus dominance, associated with increased lactate production, was observed in CV, LB and VA cases. These results indicate that this microorganism might have a role in dysbiosis of the vagina associated with these specific pathologies.info:eu-repo/semantics/publishedVersio
The detection of ultra-relativistic electrons in low Earth orbit
Aims. To better understand the radiation environment in low Earth orbit
(LEO), the analysis of in-situ observations of a variety of particles, at
different atmospheric heights, and in a wide range of energies, is needed.
Methods. We present an analysis of energetic particles, indirectly detected by
the Large Yield RAdiometer (LYRA) instrument on board ESA's Project for
On-board Autonomy 2 (PROBA2) satellite as background signal. Combining
Energetic Particle Telescope (EPT) observations with LYRA data for an
overlapping period of time, we identified these particles as electrons with an
energy range of 2 to 8 MeV. Results. The observed events are strongly
correlated to geo-magnetic activity and appear even during modest disturbances.
They are also well confined geographically within the L=4-6 McIlwain zone,
which makes it possible to identify their source. Conclusions. Although highly
energetic particles are commonly perturbing data acquisition of space
instruments, we show in this work that ultra-relativistic electrons with
energies in the range of 2-8 MeV are detected only at high latitudes, while not
present in the South Atlantic Anomaly region.Comment: Topical Issue: Flares, CMEs and SEPs and their space weather impacts;
20 pages; 7 figures; Presented during 13th European Space Weather Week, 201
Irreversible thermodynamics of open chemical networks I: Emergent cycles and broken conservation laws
In this and a companion paper we outline a general framework for the
thermodynamic description of open chemical reaction networks, with special
regard to metabolic networks regulating cellular physiology and biochemical
functions. We first introduce closed networks "in a box", whose thermodynamics
is subjected to strict physical constraints: the mass-action law, elementarity
of processes, and detailed balance. We further digress on the role of solvents
and on the seemingly unacknowledged property of network independence of free
energy landscapes. We then open the system by assuming that the concentrations
of certain substrate species (the chemostats) are fixed, whether because
promptly regulated by the environment via contact with reservoirs, or because
nearly constant in a time window. As a result, the system is driven out of
equilibrium. A rich algebraic and topological structure ensues in the network
of internal species: Emergent irreversible cycles are associated to
nonvanishing affinities, whose symmetries are dictated by the breakage of
conservation laws. These central results are resumed in the relation between the number of fundamental affinities , that of broken
conservation laws and the number of chemostats . We decompose the
steady state entropy production rate in terms of fundamental fluxes and
affinities in the spirit of Schnakenberg's theory of network thermodynamics,
paving the way for the forthcoming treatment of the linear regime, of
efficiency and tight coupling, of free energy transduction and of thermodynamic
constraints for network reconstruction.Comment: 18 page
A Simple Family of Analytical Trumpet Slices of the Schwarzschild Spacetime
We describe a simple family of analytical coordinate systems for the
Schwarzschild spacetime. The coordinates penetrate the horizon smoothly and are
spatially isotropic. Spatial slices of constant coordinate time feature a
trumpet geometry with an asymptotically cylindrical end inside the horizon at a
prescribed areal radius (with ) that serves as the free
parameter for the family. The slices also have an asymptotically flat end at
spatial infinity. In the limit the spatial slices lose their trumpet
geometry and become flat -- in this limit, our coordinates reduce to
Painlev\'e-Gullstrand coordinates.Comment: 7 pages, 3 figure
Search for an Near-IR Counterpart to the Cas A X-ray Point Source
We report deep near-infrared and optical observations of the X-ray point
source in the Cassiopeia A supernova remnant, CXO J232327.9+584842. We have
identified a J=21.4 +/- 0.3 mag and Ks=20.5 +/- 0.3 mag source within the
1-sigma error circle, but we believe this source is a foreground Pop II star
with Teff=2600-2800 K at a distance of ~2 kpc, which could not be the X-ray
point source. We do not detect any sources in this direction at the distance of
Cas A, and therefore place 3-sigma limits of R >~ 25 mag, F675W >~ 27.3 mag, J
>~ 22.5 mag and Ks >~ 21.2 mag (and roughly H >~ 20 mag) on emission from the
X-ray point source, corresponding to M_{R} >~ 8.2 mag, M_{F675W} >~ 10.7 mag,
M_{J} >~ 8.5 mag, M_{H} >~ 6.5 mag, and M_{Ks} >~ 8.0 mag, assuming a distance
of 3.4 kpc and an extinction A_{V}=5 mag.Comment: 14 pages, 7 figures. Accepted by Ap
Random paths and current fluctuations in nonequilibrium statistical mechanics
An overview is given of recent advances in nonequilibrium statistical
mechanics about the statistics of random paths and current fluctuations.
Although statistics is carried out in space for equilibrium statistical
mechanics, statistics is considered in time or spacetime for nonequilibrium
systems. In this approach, relationships have been established between
nonequilibrium properties such as the transport coefficients, the thermodynamic
entropy production, or the affinities, and quantities characterizing the
microscopic Hamiltonian dynamics and the chaos or fluctuations it may generate.
This overview presents results for classical systems in the escape-rate
formalism, stochastic processes, and open quantum systems
Non-equilibrium Thermodynamics: Structural Relaxation, Fictive temperature and Tool-Narayanaswamy phenomenology in Glasses
Starting from the second law of thermodynamics applied to an isolated system
consisting of the system surrounded by an extremely large medium, we formulate
a general non-equilibrium thermodynamic description of the system when it is
out of equilibrium. We then apply it to study the structural relaxation in
glasses and establish the phenomenology behind the concept of the fictive
temperature and of the empirical Tool-Narayanaswamy equation on firmer
theoretical foundation.Comment: 20 pages, 1 figur
Testing numerical relativity with the shifted gauge wave
Computational methods are essential to provide waveforms from coalescing
black holes, which are expected to produce strong signals for the gravitational
wave observatories being developed. Although partial simulations of the
coalescence have been reported, scientifically useful waveforms have so far not
been delivered. The goal of the AppleswithApples (AwA) Alliance is to design,
coordinate and document standardized code tests for comparing numerical
relativity codes. The first round of AwA tests have now being completed and the
results are being analyzed. These initial tests are based upon periodic
boundary conditions designed to isolate performance of the main evolution code.
Here we describe and carry out an additional test with periodic boundary
conditions which deals with an essential feature of the black hole excision
problem, namely a non-vanishing shift. The test is a shifted version of the
existing AwA gauge wave test. We show how a shift introduces an exponentially
growing instability which violates the constraints of a standard harmonic
formulation of Einstein's equations. We analyze the Cauchy problem in a
harmonic gauge and discuss particular options for suppressing instabilities in
the gauge wave tests. We implement these techniques in a finite difference
evolution algorithm and present test results. Although our application here is
limited to a model problem, the techniques should benefit the simulation of
black holes using harmonic evolution codes.Comment: Submitted to special numerical relativity issue of Classical and
Quantum Gravit
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