ANAPLASTIC LARGE-CELL LYMPHOMA (CD30+/KI-1+) - ANALYSIS OF 35 CASES FOLLOWED AT GISL CENTERS

Between January 1988 and June 1992, 35 patients with primary anaplastic large cell lymphoma (ALCL)CD30+ were referred to one of the institutions participating in GISL (Gruppo Italiano per lo Studio dei Linformi). 16 patients were treated with ProMACE-CytaBOM, two with MACOP-B, one with CHOP and one with LSA(2)-L(2). As of November 1990, all newly diagnosed patients were treated with MOPP/EBV/CAD hybrid. 27 (77%) cases of ALCL CD30+ and 8 (23%) cases of Hodgkin's-related (HR) lymphoma CD30+ were diagnosed. Extranodal disease was present in 22 cases (63%), and 8 patients (23%) had primary bone marrow involvement. Twenty-three complete remissions (CR) (66%), six partial remissions (PR) (17%) and six no remissions (NR) (17%) were achieved with induction therapy. Results achieved with ProMACE-CytaBOM and MOPP/EBV/CAD hybrid were comparable. The overall response rate (CR+PR) was 85% for patients with classic ALCL CD30+ and 87% for those with HR lymphoma CD30+. The 3 year estimated overall survival rate was 66% and the 3 year relapse free survival rate was 65% for the entire group. The only significant favourable prognostic factor was the achievement of CR with initial therapy. Our findings suggest that ALCL (CD30+/Ki-1+) has a clinical outcome similar to aggressive non-Hodgkin's lymphoma (NHL). The use of an anthracycline-containing regimen will provide a change of cure in approximately 65% of cases

An experimental study on the shear behaviour of reinforced concrete beams with macro-synthetic fibres

[EN] Shear behaviour in reinforced concrete (RC) elements can improve with an adequate amount of fibres. Research has recently determined how fibres affect shear strength, but has barely focused on macro synthetic fibre-reinforced concrete (PFRC). This paper presents the experimental results of 16 full-scale beams (eight RC, eight PFRC), 12 without transverse reinforcement. Polypropylene fibres (10 kg/m(3)) were included. Mode of failure (MOF) in shear and behaviour throughout the loading process were studied. The results obtained with fibres showed significantly improved shear strength in the RC beams with/without transverse reinforcement. A synergy between transverse reinforcement and fibres was observed in some cases. (C) 2018 Elsevier Ltd. All rights reserved.This work forms part of the PAID-06-11 programme supported by the Generalitat Valenciana.Ortiz-Navas, FR.; Navarro-Gregori, J.; Leiva Herdocia, G.; Serna Ros, P.; Cuenca Asensio, E. (2018). An experimental study on the shear behaviour of reinforced concrete beams with macro-synthetic fibres. Construction and Building Materials. 169:888-899. https://doi.org/10.1016/j.conbuildmat.2018.02.023S88889916