Testing fixed points in the 2D O(3) non-linear sigma model

Using high statistic numerical results we investigate the properties of the O(3) non-linear 2D sigma-model. Our main concern is the detection of an hypothetical Kosterlitz-Thouless-like (KT) phase transition which would contradict the asymptotic freedom scenario. Our results do not support such a KT-like phase transition.Comment: Latex, 7 pgs, 4 eps-figures. Added more analysis on the KT-transition. 4-loop beta function contains corrections from D.-S.Shin (hep-lat/9810025). In a note-added we comment on the consequences of these corrections on our previous reference [16

Clinical presentation and natural history of infantile-onset ascending spastic paralysis from three families with an ALS2 founder variant.

Biallelic mutations of the alsin Rho guanine nucleotide exchange factor (ALS2) gene cause a group of overlapping autosomal recessive neurodegenerative disorders including infantile-onset ascending hereditary spastic paralysis (IAHSP), juvenile primary lateral sclerosis (JPLS), and juvenile amyotrophic lateral sclerosis (JALS/ALS2), caused by retrograde degeneration of the upper motor neurons of the pyramidal tracts. Here, we describe 11 individuals with IAHSP, aged 2-48 years, with IAHSP from three unrelated consanguineous Iranian families carrying the homozygous c.1640+1G>A founder mutation in ALS2. Three affected siblings from one family exhibit generalized dystonia which has not been previously described in families with IAHSP and has only been reported in three unrelated consanguineous families with JALS/ALS2. We report the oldest individuals with IAHSP to date and provide evidence that these patients survive well into their late 40s with preserved cognition and normal eye movements. Our study delineates the phenotypic spectrum of IAHSP and ALS2-related disorders and provides valuable insights into the natural disease course

Protein Tyrosine Phospatase PTPRR isoforms in cellular signaling and trafficking.

Contains fulltext : 27024.pdf (publisher's version ) (Open Access)Previous work has revealed the existence of two Protein Tyrosine Phosphatases in mouse, PTPBR7 and PTP-SL, that were in part identical, suggesting that they originated from the same gene, termed Ptprr (1,5,6). In this thesis, I report on the characterization of the various PTPRR isoforms in neuronal cells and demonstrate that the single copy mouse gene Ptprr gives rise to four mRNAs that encode PTPBR7, PTP-SL and two PTPPBS protein variants through the use of distinct promoters, alternative splicing and differential translation initiation starts. In addition, the receptor-type PTPBR7 protein isoform was found to undergo N-terminal proteolytic cleavage at a furin-like convertase consensus site, adding an additional, fifth, member for which the name PTPBR7-65 was coined. Localization studies that focused on the different PTPRR isoforms revealed that PTPBR7 and PTP-SL are both present and co-localize in late endocytic compartments and in the Golgi area. PTPBR7 shows an additional localization at the plasma membrane (1,7), and interestingly on early endosomes as well. The 42 and 37 kDa PTPPBS proteins are genuine cytosolic proteins. Live-imaging studies revealed that PTPBR7 and PTP-SL vesicles are highly motile in both anterograde and retrograde directions. PTP-SL is involved in the ERK-MAP kinase signaling pathway, but interestingly, we also found it to interact with the 4-adaptin subunit of the AP-4 adaptor complex, an important component of the vesicular transport machinery. Taken together, studies described in this thesis point to a possible role for PTP-SL, and other PTPRR family members, in vesicle trafficking between the Golgi-apparatus and endocytic compartments and localized signaling.RU Radboud Universiteit Nijmegen, 24 november 2005Promotor : Wieringa, B. Co-promotores : Fransen, J.A.M., Hendriks, W.J.A.J.176 p

Conservative Surgical Treatment of the Jaw Cysts in Children: Case Study of Five Patients

Aims: Conservative treatment of jaw cysts establishes low surgical complication risk and protects vital anatomical structures such as inferior alveolar nerve, maxillary sinus and permanent tooth germs. Marsupialization and decompression have been widely used in children. The aim of this study was to evaluate the results of the conservative treatment of jaw cysts in five children. Materials and Methods: This article presents case series of marsupialization in jaw cysts associated with impacted teeth in five children. A total of nine impacted teeth within the cystic lesions were observed. Results: Complete resolution of all cystic lesions and simultaneous eruption of six impacted teeth within the cyst were managed. The other two teeth were erupted orthodontically and one had to be extracted. Conclusions: Marsupialization is effective for the treatment of cystic lesions in growing patients as it preserves vital anatomical structures and enables eruption of the impacted teeth within the cyst.Keywords: Children, conservative treatment, cyst treatment, marsupializatio

Patch antenna with slits at 8 GHz

Due to copyright restrictions, the access to the full text of this article is only available via subscription.In this paper, a rectangular shaped patch antenna with two equal rectangular shaped slits on each side and one at the top has been demonstrated. By modifying the size and the shape of the initial antenna, a radiation efficient and performance enhanced antenna has been designed. The proposed antenna resonances at 8.0 GHz with the peak gain of 6.58 dB, allowing the antenna to be used in wireless communication applications

Is 2 mm a safe distance from the inferior alveolar canal to avoid neurosensory complications in implant surgery?

Aim: The aim of the present study was to compare the neurosensory complications related to implants inserted closer than 2 mm to the inferior alveolar canal (IAC) with those inserted further than 2 mm.Materials and Methods: A total of 474 implants in 314 patients placed posterior to mental foramen area were evaluated retrospectively on panoramic radiographs. Patients were divided into two groups regarding implant proximity to the IAC (Group 1, distance ≤2 mm, Group 2, distance >2 mm). Postoperative neurosensory complications (pain and paresthesia) were recorded. Chi-square test was used for statistical comparison and P ≤ 0.05 was considered significant.Results: One hundred and fifty-three implants (32.2%) were inserted closer than 2 mm to the IAC whereas 321 implants (67.8%) were inserted further than 2 mm. Three implants which had a distance of 0 mm to the IAC (0.63%) caused paresthesia after surgery. Implant distance to IAC did not show a significant difference regarding pain and paresthesia (P = 0.06 and P = 0.08, respectively).Conclusion: When 2 mm is considered as a safety distance, the distance of the implants to the IAC did not yield any statistical difference regarding postoperative neurosensory complications.Keywords: Dental implants, inferior alveolar nerve injury, neurosensory complicatio

Is 2 mm a safe distance from the inferior alveolar canal to avoid neurosensory complications in implant surgery?

Aim: The aim of the present study was to compare the neurosensory complications related to implants inserted closer than 2 mm to the inferior alveolar canal (IAC) with those inserted further than 2 mm