Remarques sur des Cnidaires du type de <i>Microhydrula pontica</i> Valkanov 1965, trouvés à Roscoff

Two different forms of a small Cnidaria extremely reduced in his organisation and corresponding to the Hydrozoa Microhydrula pontica Valkanov 1965 are found during the whole year in the region of Roscoff on biological substratums which are developping at the surface in prolongated contact with the water. These two forms are distinguished by some histological characters, but especially by the cnidom. Each form has only one type of cnidocysts. The form which remains in the genus and species Microhydrula pontica has classical eurytelian microbasic cnidocysts; the other has a partiular type of cnidocysts, which have been described as 'semiophors'. The basal part is of the eurythelian microbasic type, but the filament is subdivided in two portions, separated by a elbow having a special spine as ornement. The genus and the species Rhaptapagis cantacuzenei n.g., n.sp. Are proposed for this form and the family of the Microhydrulidae has for the moment these two genus

A Universal Decline Law of Classical Novae. III. GQ Mus 1983

We present a unified model of infrared (IR), optical, ultraviolet (UV), and X-ray light curves for the 1983 outburst of GQ Muscae (Nova Muscae 1983) and estimate its white dwarf (WD) mass. Based on an optically thick wind model of nova outbursts, we model the optical and IR light curves with free-free emission, and the UV 1455 \AA and supersoft X-ray light curves with blackbody emission. The best fit model that reproduces simultaneously the IR, optical, UV 1455 \AA, and supersoft X-ray observations is a 0.7 \pm 0.05 M_\sun WD for an assumed chemical composition of the envelope, X=0.35-0.55, X_{CNO} =0.2-0.35, and Z = 0.02, by mass weight. The mass lost by the wind is estimated to be \Delta M_{wind} \sim 2 \times 10^{-5} M_\sun. We provide a new determination of the reddening, E(B-V) = 0.55 \pm 0.05, and of the distance, \sim 5 kpc. Finally, we discuss the strong UV flash that took place on JD 2,445,499 (151 days after the outburst).Comment: to appear in ApJ, 17 pages including 20 figure

Arthritis in primary Sjögren&#039;s syndrome: Characteristics, outcome and treatment from French multicenter retrospective study

Objective To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen. Methods We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls). Results 57 patients (93% women) were included with a median age of 54 years [45–63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6–12] vs. 2 [1–4], p &lt; .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5–77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens. Conclusion pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined

An oestrogen-producing seminoma responsible for gynaecomastia

International audienceIn feminising testicular tumours, oestrogens can be either secreted by the tumour itself or produced by normal Leydig cells in response to paracrine and/or endocrine stimulation by hCG. Typical hormonal Leydig cell tumour patterns include: plasma oestradiol levels > 300 pmol/l on day 3 following an hCG injection, reduced plasma testosterone, and normal plasma hCG and gonadotrophin levels. Except for elevated plasma oestradiol levels, opposite results are observed in seminomas. We report a case of oestrogen-secreting seminoma mimicking a Leydig cell tumour. A 24-year-old Caucasian patient had complained of gynaecomastia for 6 months before admission. Hormonal pattern was typical of Leydig cell tumour. A 1.4 cm tumour was found in the left testis and confirmed on sonography. Considering the likely diagnosis of Leydig cell tumour, the patient was treated by tumourectomy. Surprisingly, pathological examination revealed a pure seminoma. Perifusion experiments showed that the tumour was able to secrete significant amounts of oestradiol. In addition, hCG induced a two-fold increase in oestradiol production from perifused tumour explants. Immunohistochemistry revealed that the tumour was composed of nests of seminoma cells intermingled with lymphoid infiltrates. Tumour cells also expressed aromatase, the hCG/LH receptor and the Leydig cell marker relaxin-like factor, but were betahCG-negative. These results demonstrate that a pure seminoma of the testis is able to synthesise and secrete oestrogens. They also illustrate that the body of proof favouring the diagnosis of feminising Leydig cell tumour of the testis is not rigorously specific

Twenty months development for the Cassis telescope: re-use building blocks and concurrent engineering

On board of the ExoMars Trace Gas Orbiter (TGO), the Colour and Stereo Surface Imaging System (CaSSIS) developed under the lead of University of Bern, has the mission to provide stereo images of the planet's surface in colour at a resolution of better than 5 m (4.54m from a circular orbit of 400 km) for enhancing our knowledge of the surface of Mars [1]

Auto-antibodies to vascular endothelial cadherin in humans: association with autoimmune diseases.

International audienceTo identify patients with autoimmune diseases who are at high risk of developing vascular cell dysfunction, early biomarkers must be identified. This study was designed to detect and characterize circulating autoantibodies to VE-cadherin (AAVEs) in patients with early-stage autoimmune diseases. An enzyme-linked immunosorbent assay (ELISA) was developed to capture autoantibodies, using a recombinant human VE-cadherin fragment covering the extracellular domains as a target antigen. AAVEs specificity for the target antigen was confirmed by western blotting. Basal AAVEs levels were determined for healthy donors (n=75). Sera from patients (n=100) with various autoimmune diseases, including rheumatoid arthritis (n=23), systemic lupus erythematosus (SLE, n=31), systemic sclerosis (n=30), and Behçet's disease (BD, n=16) were also tested. Levels of AAVEs were significantly higher in rheumatoid arthritis (P<0.0001), SLE (P<0.05), and BD (P<0.05) populations than in healthy subjects. Purified immunoglobulin G (IgG) from a BD patient with exceptionally high AAVEs levels recognized the EC1-4 fragment in western blots. Further characterization of the epitopes recognized by AAVEs showed that BD patients had antibodies specific for the EC3 and EC4 domains, whereas SLE patients preferentially recognized the EC1 fragment. This suggests that distinct epitopes of human VE-cadherin might be recognized in different immune diseases. Purified IgG from BD patients was found to induce endothelial cell retraction, redistribution of VE-cadherin, and cause the formation of numerous intercellular gaps. Altogether, these data demonstrate a potential pathogenic effect of AAVEs isolated from patients with dysimmune disease. This is the first description of AAVEs in humans. Because regions EC1 and EC3-4 have been shown to be involved in homophilic VE-cadherin interactions, AAVEs produced in the course of dysimmune diseases might be specific biomarkers for endothelial injury, which is part of the early pathogenicity of these diseases